| Literature DB >> 32972334 |
Kristina Shkirkova1, Krista Lamorie-Foote1,2, Michelle Connor1,2, Arati Patel1,2, Giuseppe Barisano1, Hans Baertsch1,2, Qinghai Liu1, Todd E Morgan3, Constantinos Sioutas4, William J Mack1,2,5.
Abstract
Fine and ultra-fine particulate matter (PM) are major constituents of urban air pollution and recognized risk factors for cardiovascular diseases. This review examined the effects of PM exposure on vascular tissue. Specific mechanisms by which PM affects the vasculature include inflammation, oxidative stress, actions on vascular tone and vasomotor responses, as well as atherosclerotic plaque formation. Further, there appears to be a greater PM exposure effect on susceptible individuals with pre-existing cardiovascular conditions.Entities:
Keywords: Particulate matter; air pollution; atherosclerotic plaque; endothelial cells; inflammation; oxidative stress; vascular tissue; vascular tone
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Year: 2020 PMID: 32972334 PMCID: PMC7758078 DOI: 10.1080/10937404.2020.1822971
Source DB: PubMed Journal: J Toxicol Environ Health B Crit Rev ISSN: 1093-7404 Impact factor: 6.393