Jiahong Chen1, Maozhang Li2, Shumin Fang2, Xiaobo Zhou2, Jinxian Liao2, Shengbang Yang3, Jianguo Zhu3, Renqiang He3, Jianming Lu4, Funeng Jiang5, Xiaoming Xu6, Weide Zhong7. 1. Department of Urology, Huizhou Municipal Central People's Hospital, Huizhou, Guangdong, China . 2. Department of Urology, Huizhou Municipal Central People's Hospital, Huizhou, Guangdong, China. 3. Guizhou University School of Medicine, Guiyang, China. 4. Department ofUrology, Zhujiang Hospital of Southern Medical University, Guangzho, China. 5. Department of Urology, Guangdong Key Laboratory of Clinical Molecular Medicine and Diagnostics, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China . 6. Departmentof Urology, Hua Mei Hospital, University of Chinese Academy of Science, Ningbo,China. 7. Department of Urology, Guangdong Key Laboratory of Clinical Molecular Medicine and Diagnostics, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China. zhongwd2009@live.cn.
Abstract
PURPOSE: To investigate the clinical relevance and biological function of the kinesin super-family protein 4A (KIF4A) expression in prostate cancer (PCa). METHODS: We examined 1) the relationship between the expression of KIF4A and clinico-pathological characteristics of PCa patients using a tissue microarray and the Cancer Genome Atlas database, 2) the prognostic value of KIF4A expression in patients using Kaplan-Meier plots and 3) the functions of KIF4A in LNCaP and DU145 cells, such as cell proliferation, cell cycle and cell apoptosis. RESULTS: Compared with normal prostate, the mRNA and protein expressions of KIF4A were up-regulated in PCa. The up-regulation expression rates of KIF4A in PCa were significantly related to the Gleason score (P.
PURPOSE: To investigate the clinical relevance and biological function of the kinesin super-family protein 4A (KIF4A) expression in prostate cancer (PCa). METHODS: We examined 1) the relationship between the expression of KIF4A and clinico-pathological characteristics of PCa patients using a tissue microarray and the Cancer Genome Atlas database, 2) the prognostic value of KIF4A expression in patients using Kaplan-Meier plots and 3) the functions of KIF4A in LNCaP and DU145 cells, such as cell proliferation, cell cycle and cell apoptosis. RESULTS: Compared with normal prostate, the mRNA and protein expressions of KIF4A were up-regulated in PCa. The up-regulation expression rates of KIF4A in PCa were significantly related to the Gleason score (P.