Andrew Faramand1, Ajay Niranjan2, John Flickinger2, Edward Monaco2, L Dade Lunsford2. 1. Department of Neurological Surgery and Radiation Oncology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA. Electronic address: faramanda@upmc.edu. 2. Department of Neurological Surgery and Radiation Oncology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Abstract
BACKGROUND: Management of intracranial Langerhans cell histiocytosis generally includes surgical resection. CASE DESCRIPTION: A female patient with a diagnosis of Langerhans cell histiocytosis developed multiple brain lesions. As part of her multimodality treatment, she underwent Gamma Knife stereotactic radiosurgery on 4 occasions over a 20-year period. All tumors showed significant shrinkage on serial imaging after initially demonstrating a transient expansion. No permanent postradiosurgery complications occurred. CONCLUSIONS: As part of multimodality management of this recurrent and refractory disease, Gamma Knife stereotactic radiosurgery should be considered an important salvage option that can control local disease and obviate the need for invasive surgery.
BACKGROUND: Management of intracranial Langerhans cell histiocytosis generally includes surgical resection. CASE DESCRIPTION: A female patient with a diagnosis of Langerhans cell histiocytosis developed multiple brain lesions. As part of her multimodality treatment, she underwent Gamma Knife stereotactic radiosurgery on 4 occasions over a 20-year period. All tumors showed significant shrinkage on serial imaging after initially demonstrating a transient expansion. No permanent postradiosurgery complications occurred. CONCLUSIONS: As part of multimodality management of this recurrent and refractory disease, Gamma Knife stereotactic radiosurgery should be considered an important salvage option that can control local disease and obviate the need for invasive surgery.
Authors: Nallammai Muthiah; Kamil W Nowicki; Jennifer L Picarsic; Michael P D'Angelo; Daniel F Marker; Edward G Andrews; Edward A Monaco; Ajay Niranjan Journal: J Neurosurg Case Lessons Date: 2021-05-10