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Literature DB >> 32970276

A Review of Prostanoid Receptors: Expression, Characterization, Regulation, and Mechanism of Action.

Abstract

Prostaglandin signaling controls a wide range of biological processes from blood pressure homeostasis to inflammation and resolution thereof to the perception of pain to cell survival. Disruption of normal prostanoid signaling is implicated in numerous disease states. Prostaglandin signaling is facilitated by G-protein-coupled, prostanoid-specific receptors and the array of associated G-proteins. This review focuses on the expression, characterization, regulation, and mechanism of action of prostanoid receptors with particular emphasis on human isoforms.

Entities: Chemical Disease Species

Keywords: G-protein; eicosanoid; prostaglandin; prostanoid; receptor; signaling

Year: 2020 PMID： 32970276 PMCID： PMC7991060 DOI： 10.1007/s12079-020-00585-0

Source DB: PubMed Journal: J Cell Commun Signal ISSN： 1873-9601 Impact factor: 5.782

211 in total

1. Loss of the EP2 prostaglandin E2 receptor in immortalized human keratinocytes results in increased invasiveness and decreased paxillin expression.

Authors: Raymond L Konger; Glynis A Scott; Yvonne Landt; Jack H Ladenson; Alice P Pentland
Journal: Am J Pathol Date: 2002-12 Impact factor: 4.307

2. Comprehensive biochemical analysis of rare prostacyclin receptor variants: study of association of signaling with coronary artery obstruction.

Authors: Jeremiah Stitham; Eric Arehart; Larkin Elderon; Scott R Gleim; Karen Douville; Zsolt Kasza; Kristina Fetalvero; Todd MacKenzie; John Robb; Kathleen A Martin; John Hwa
Journal: J Biol Chem Date: 2010-12-28 Impact factor: 5.157

3. Activation of FP prostanoid receptor isoforms leads to Rho-mediated changes in cell morphology and in the cell cytoskeleton.

Authors: K L Pierce; H Fujino; D Srinivasan; J W Regan
Journal: J Biol Chem Date: 1999-12-10 Impact factor: 5.157

4. EP4/EP2 receptor-specific prostaglandin E2 regulation of interleukin-6 generation by human HSB.2 early T cells.

Authors: L Zeng; S An; E J Goetzl
Journal: J Pharmacol Exp Ther Date: 1998-09 Impact factor: 4.030

5. Internalization and sequestration of the human prostacyclin receptor.

Authors: E M Smyth; S C Austin; M P Reilly; G A FitzGerald
Journal: J Biol Chem Date: 2000-10-13 Impact factor: 5.157

6. Evidence that phospholipase delta1 is the effector in the Gh (transglutaminase II)-mediated signaling.

Authors: J F Feng; S G Rhee; M J Im
Journal: J Biol Chem Date: 1996-07-12 Impact factor: 5.157

7. Functional reconstitution of platelet thromboxane A2 receptors with Gq and Gi2 in phospholipid vesicles.

Authors: F Ushikubi; K Nakamura; S Narumiya
Journal: Mol Pharmacol Date: 1994-11 Impact factor: 4.436

8. Phosphorylation of the prostacyclin receptor during homologous desensitization. A critical role for protein kinase c.

Authors: E M Smyth; W H Li; G A FitzGerald
Journal: J Biol Chem Date: 1998-09-04 Impact factor: 5.157

9. Homologous desensitization of signalling by the alpha (alpha) isoform of the human thromboxane A2 receptor: a specific role for nitric oxide signalling.

Authors: Leanne P Kelley-Hickie; Martina B O'Keeffe; Helen M Reid; B Therese Kinsella
Journal: Biochim Biophys Acta Date: 2007-03-28

10. Towards complete sets of farnesylated and geranylgeranylated proteins.

Authors: Sebastian Maurer-Stroh; Manfred Koranda; Wolfgang Benetka; Georg Schneider; Fernanda L Sirota; Frank Eisenhaber
Journal: PLoS Comput Biol Date: 2007-02-23 Impact factor: 4.475

10 in total

1. EP3 enhances adhesion and cytotoxicity of NK cells toward hepatic stellate cells in a murine liver fibrosis model.

Authors: Xixi Tao; Rui Zhang; Ronglu Du; Tingting Yu; Hui Yang; Jiwen Li; Yuhong Wang; Qian Liu; Shengkai Zuo; Xi Wang; Michael Lazarus; Lu Zhou; Bangmao Wang; Ying Yu; Yujun Shen
Journal: J Exp Med Date: 2022-04-14 Impact factor: 14.307

Review 2. Remodeling of Adipose Tissues by Fatty Acids: Mechanistic Update on Browning and Thermogenesis by n-3 Polyunsaturated Fatty Acids.

Authors: Radha Raman Raj; Sydney Lofquist; Mi-Jeong Lee
Journal: Pharm Res Date: 2022-09-01 Impact factor: 4.580

Review 10. A review of non-prostanoid, eicosanoid receptors: expression, characterization, regulation, and mechanism of action.

Authors: Roger G Biringer
Journal: J Cell Commun Signal Date: 2021-06-26 Impact factor: 5.782

10 in total

A Review of Prostanoid Receptors: Expression, Characterization, Regulation, and Mechanism of Action.

1. Loss of the EP2 prostaglandin E2 receptor in immortalized human keratinocytes results in increased invasiveness and decreased paxillin expression.

2. Comprehensive biochemical analysis of rare prostacyclin receptor variants: study of association of signaling with coronary artery obstruction.

3. Activation of FP prostanoid receptor isoforms leads to Rho-mediated changes in cell morphology and in the cell cytoskeleton.

4. EP4/EP2 receptor-specific prostaglandin E2 regulation of interleukin-6 generation by human HSB.2 early T cells.

5. Internalization and sequestration of the human prostacyclin receptor.

6. Evidence that phospholipase delta1 is the effector in the Gh (transglutaminase II)-mediated signaling.

7. Functional reconstitution of platelet thromboxane A2 receptors with Gq and Gi2 in phospholipid vesicles.

8. Phosphorylation of the prostacyclin receptor during homologous desensitization. A critical role for protein kinase c.

9. Homologous desensitization of signalling by the alpha (alpha) isoform of the human thromboxane A2 receptor: a specific role for nitric oxide signalling.

10. Towards complete sets of farnesylated and geranylgeranylated proteins.

1. EP3 enhances adhesion and cytotoxicity of NK cells toward hepatic stellate cells in a murine liver fibrosis model.

Review 2. Remodeling of Adipose Tissues by Fatty Acids: Mechanistic Update on Browning and Thermogenesis by n-3 Polyunsaturated Fatty Acids.

Review 3. Uteroplacental Circulation in Normal Pregnancy and Preeclampsia: Functional Adaptation and Maladaptation.

4. Prostanoid Signaling in Cancers: Expression and Regulation Patterns of Enzymes and Receptors.

Review 5. Effect of Prostanoids on Human Platelet Function: An Overview.

Review 6. Prostanoid Metabolites as Biomarkers in Human Disease.

Review 7. Eicosanoids in inflammation in the blood and the vessel.

8. Ouabain Enhances Gap Junctional Intercellular Communication by Inducing Paracrine Secretion of Prostaglandin E2.

9. EP3 Receptor Deficiency Improves Vascular Remodeling and Cognitive Impairment in Cerebral Small Vessel Disease.

Review 10. A review of non-prostanoid, eicosanoid receptors: expression, characterization, regulation, and mechanism of action.