Literature DB >> 32968245

Modular synthesis enables molecular ju-jitsu in the fight against antibiotic resistance.

Daniel J Blair, Martin D Burke.   

Abstract

Keywords:  Drug discovery; Organic chemistry; Structural biology; Synthesis

Mesh：

Substances：

Year:  2020        PMID： 32968245     DOI： 10.1038/d41586-020-02565-1

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


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  9 in total

Review 1.  Streptogramin antibiotics: mode of action and resistance.

Authors:  Nicole J Johnston; Tariq A Mukhtar; Gerard D Wright
Journal:  Curr Drug Targets       Date:  2002-08       Impact factor: 3.465

Review 2.  Prospects for new antibiotics: a molecule-centered perspective.

Authors:  Christopher T Walsh; Timothy A Wencewicz
Journal:  J Antibiot (Tokyo)       Date:  2013-06-12       Impact factor: 2.649

Review 3.  Critical analysis of antibacterial agents in clinical development.

Authors:  Ursula Theuretzbacher; Karen Bush; Stephan Harbarth; Mical Paul; John H Rex; Evelina Tacconelli; Guy E Thwaites
Journal:  Nat Rev Microbiol       Date:  2020-03-09       Impact factor: 60.633

4.  Modular, Scalable Synthesis of Group A Streptogramin Antibiotics.

Authors:  Qi Li; Ian B Seiple
Journal:  J Am Chem Soc       Date:  2017-09-18       Impact factor: 15.419

Review 5.  NXL-103, a combination of flopristin and linopristin, for the potential treatment of bacterial infections including community-acquired pneumonia and MRSA.

Authors:  Amani D Politano; Robert G Sawyer
Journal:  Curr Opin Investig Drugs       Date:  2010-02

6.  Quinupristin-dalfopristin resistance in gram-positive bacteria: mechanism of resistance and epidemiology.

Authors:  Ellie Hershberger; Susan Donabedian; Konstantinos Konstantinou; Marcus J Zervos
Journal:  Clin Infect Dis       Date:  2003-12-05       Impact factor: 9.079

7.  Toward Generalization of Iterative Small Molecule Synthesis.

Authors:  Jonathan W Lehmann; Daniel J Blair; Martin D Burke
Journal:  Nat Rev Chem       Date:  2018-03-07       Impact factor: 34.035

8.  Potential for reduction of streptogramin A resistance revealed by structural analysis of acetyltransferase VatA.

Authors:  Peter J Stogios; Misty L Kuhn; Elena Evdokimova; Patrice Courvalin; Wayne F Anderson; Alexei Savchenko
Journal:  Antimicrob Agents Chemother       Date:  2014-09-15       Impact factor: 5.191

Review 9.  The global preclinical antibacterial pipeline.

Authors:  Ursula Theuretzbacher; Kevin Outterson; Aleks Engel; Anders Karlén
Journal:  Nat Rev Microbiol       Date:  2019-11-19       Impact factor: 60.633
  9 in total

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