Literature DB >> 32967863

Mendelian Randomization Analysis of n-6 Polyunsaturated Fatty Acid Levels and Pancreatic Cancer Risk.

Dalia H Ghoneim1, Jingjing Zhu1, Wei Zheng2, Jirong Long2, Harvey J Murff3, Fei Ye4, Veronica Wendy Setiawan5, Lynne R Wilkens1, Nikhil K Khankari2, Philip Haycock6, Samuel O Antwi7, Yaohua Yang2, Alan A Arslan8, Laura E Beane Freeman9, Paige M Bracci10, Federico Canzian11, Mengmeng Du12, Steven Gallinger13, Graham G Giles14,15,16, Phyllis J Goodman17, Charles Kooperberg18, Loïc Le Marchand1, Rachel E Neale19, Ghislaine Scelo20, Kala Visvanathan21,22, Emily White23, Demetrius Albanes9, Pilar Amiano24, Gabriella Andreotti9, Ana Babic25, William R Bamlet26, Sonja I Berndt9, Lauren K Brais25, Paul Brennan20, Bas Bueno-de-Mesquita27,28,29,30, Julie E Buring31,32, Peter T Campbell33, Kari G Rabe26, Stephen J Chanock9, Priya Duggal21, Charles S Fuchs34,35,36, J Michael Gaziano32,37, Michael G Goggins38, Thilo Hackert39, Manal M Hassan40, Kathy J Helzlsouer41, Elizabeth A Holly10, Robert N Hoover9, Verena Katske42, Robert C Kurtz43, I-Min Lee31,32, Núria Malats44, Roger L Milne14,15,16, Neil Murphy45, Ann L Oberg26, Miquel Porta46, Nathaniel Rothman9, Howard D Sesso31,32, Debra T Silverman9, Ian M Thompson47, Jean Wactawski-Wende48, Xiaoliang Wang23, Nicolas Wentzensen9, Herbert Yu1, Anne Zeleniuch-Jacquotte49, Kai Yu9, Brian M Wolpin25, Eric J Jacobs50, Eric J Duell51, Harvey A Risch52, Gloria M Petersen26, Laufey T Amundadottir53, Peter Kraft54, Alison P Klein21,22,38, Rachel Z Stolzenberg-Solomon9, Xiao-Ou Shu55, Lang Wu56.   

Abstract

BACKGROUND: Whether circulating polyunsaturated fatty acid (PUFA) levels are associated with pancreatic cancer risk is uncertain. Mendelian randomization (MR) represents a study design using genetic instruments to better characterize the relationship between exposure and outcome.
METHODS: We utilized data from genome-wide association studies within the Pancreatic Cancer Cohort Consortium and Pancreatic Cancer Case-Control Consortium, involving approximately 9,269 cases and 12,530 controls of European descent, to evaluate associations between pancreatic cancer risk and genetically predicted plasma n-6 PUFA levels. Conventional MR analyses were performed using individual-level and summary-level data.
RESULTS: Using genetic instruments, we did not find evidence of associations between genetically predicted plasma n-6 PUFA levels and pancreatic cancer risk [estimates per one SD increase in each PUFA-specific weighted genetic score using summary statistics: linoleic acid odds ratio (OR) = 1.00, 95% confidence interval (CI) = 0.98-1.02; arachidonic acid OR = 1.00, 95% CI = 0.99-1.01; and dihomo-gamma-linolenic acid OR = 0.95, 95% CI = 0.87-1.02]. The OR estimates remained virtually unchanged after adjustment for covariates, using individual-level data or summary statistics, or stratification by age and sex.
CONCLUSIONS: Our results suggest that variations of genetically determined plasma n-6 PUFA levels are not associated with pancreatic cancer risk. IMPACT: These results suggest that modifying n-6 PUFA levels through food sources or supplementation may not influence risk of pancreatic cancer. ©2020 American Association for Cancer Research.

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Year:  2020        PMID: 32967863      PMCID: PMC7710600          DOI: 10.1158/1055-9965.EPI-20-0651

Source DB:  PubMed          Journal:  Cancer Epidemiol Biomarkers Prev        ISSN: 1055-9965            Impact factor:   4.254


  8 in total

Review 1.  Fish or long-chain (n-3) PUFA intake is not associated with pancreatic cancer risk in a meta-analysis and systematic review.

Authors:  Bo Qin; Pengcheng Xun; Ka He
Journal:  J Nutr       Date:  2012-04-25       Impact factor: 4.798

2.  Survival in population-based pancreatic cancer patients: San Francisco Bay area, 1995-1999.

Authors:  Zhihong Gong; Elizabeth A Holly; Paige M Bracci
Journal:  Am J Epidemiol       Date:  2011-11-01       Impact factor: 4.897

3.  Opposing effects of n-6 and n-3 polyunsaturated fatty acids on pancreatic cancer growth.

Authors:  Hitoshi Funahashi; Makoto Satake; Sascha Hasan; Hirozumi Sawai; Robert A Newman; Howard A Reber; Oscar J Hines; Guido Eibl
Journal:  Pancreas       Date:  2008-05       Impact factor: 3.327

4.  Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.

Authors:  Weihua Guan; Brian T Steffen; Rozenn N Lemaitre; Jason H Y Wu; Toshiko Tanaka; Ani Manichaikul; Millennia Foy; Luigi Ferrucci; Myriam Fornage; Dariush Mozafarrian; Michael Y Tsai; Lyn M Steffen; Stephen S Rich; Lu Wang; Jennifer A Nettleton; Weihong Tang; Xiangjun Gu; Stafania Bandinelli; Irena B King; Barbara McKnight; Bruce M Psaty; David Siscovick; Luc Djousse; Yii-Der Ida Chen
Journal:  Circ Cardiovasc Genet       Date:  2014-05-13

5.  Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium.

Authors:  Rozenn N Lemaitre; Toshiko Tanaka; Weihong Tang; Ani Manichaikul; Millennia Foy; Edmond K Kabagambe; Jennifer A Nettleton; Irena B King; Lu-Chen Weng; Sayanti Bhattacharya; Stefania Bandinelli; Joshua C Bis; Stephen S Rich; David R Jacobs; Antonio Cherubini; Barbara McKnight; Shuang Liang; Xiangjun Gu; Kenneth Rice; Cathy C Laurie; Thomas Lumley; Brian L Browning; Bruce M Psaty; Yii-Der I Chen; Yechiel Friedlander; Luc Djousse; Jason H Y Wu; David S Siscovick; André G Uitterlinden; Donna K Arnett; Luigi Ferrucci; Myriam Fornage; Michael Y Tsai; Dariush Mozaffarian; Lyn M Steffen
Journal:  PLoS Genet       Date:  2011-07-28       Impact factor: 5.917

6.  Mendelian randomization analysis with multiple genetic variants using summarized data.

Authors:  Stephen Burgess; Adam Butterworth; Simon G Thompson
Journal:  Genet Epidemiol       Date:  2013-09-20       Impact factor: 2.135

7.  Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer.

Authors:  Alison P Klein; Brian M Wolpin; Harvey A Risch; Rachael Z Stolzenberg-Solomon; Evelina Mocci; Mingfeng Zhang; Federico Canzian; Erica J Childs; Jason W Hoskins; Ashley Jermusyk; Jun Zhong; Fei Chen; Demetrius Albanes; Gabriella Andreotti; Alan A Arslan; Ana Babic; William R Bamlet; Laura Beane-Freeman; Sonja I Berndt; Amanda Blackford; Michael Borges; Ayelet Borgida; Paige M Bracci; Lauren Brais; Paul Brennan; Hermann Brenner; Bas Bueno-de-Mesquita; Julie Buring; Daniele Campa; Gabriele Capurso; Giulia Martina Cavestro; Kari G Chaffee; Charles C Chung; Sean Cleary; Michelle Cotterchio; Frederike Dijk; Eric J Duell; Lenka Foretova; Charles Fuchs; Niccola Funel; Steven Gallinger; J Michael M Gaziano; Maria Gazouli; Graham G Giles; Edward Giovannucci; Michael Goggins; Gary E Goodman; Phyllis J Goodman; Thilo Hackert; Christopher Haiman; Patricia Hartge; Manal Hasan; Peter Hegyi; Kathy J Helzlsouer; Joseph Herman; Ivana Holcatova; Elizabeth A Holly; Robert Hoover; Rayjean J Hung; Eric J Jacobs; Krzysztof Jamroziak; Vladimir Janout; Rudolf Kaaks; Kay-Tee Khaw; Eric A Klein; Manolis Kogevinas; Charles Kooperberg; Matthew H Kulke; Juozas Kupcinskas; Robert J Kurtz; Daniel Laheru; Stefano Landi; Rita T Lawlor; I-Min Lee; Loic LeMarchand; Lingeng Lu; Núria Malats; Andrea Mambrini; Satu Mannisto; Roger L Milne; Beatrice Mohelníková-Duchoňová; Rachel E Neale; John P Neoptolemos; Ann L Oberg; Sara H Olson; Irene Orlow; Claudio Pasquali; Alpa V Patel; Ulrike Peters; Raffaele Pezzilli; Miquel Porta; Francisco X Real; Nathaniel Rothman; Ghislaine Scelo; Howard D Sesso; Gianluca Severi; Xiao-Ou Shu; Debra Silverman; Jill P Smith; Pavel Soucek; Malin Sund; Renata Talar-Wojnarowska; Francesca Tavano; Mark D Thornquist; Geoffrey S Tobias; Stephen K Van Den Eeden; Yogesh Vashist; Kala Visvanathan; Pavel Vodicka; Jean Wactawski-Wende; Zhaoming Wang; Nicolas Wentzensen; Emily White; Herbert Yu; Kai Yu; Anne Zeleniuch-Jacquotte; Wei Zheng; Peter Kraft; Donghui Li; Stephen Chanock; Ofure Obazee; Gloria M Petersen; Laufey T Amundadottir
Journal:  Nat Commun       Date:  2018-02-08       Impact factor: 14.919

8.  Mendelian Randomization of Circulating Polyunsaturated Fatty Acids and Colorectal Cancer Risk.

Authors:  Nikhil K Khankari; Barbara L Banbury; Maria C Borges; Philip Haycock; Demetrius Albanes; Volker Arndt; Sonja I Berndt; Stéphane Bézieau; Hermann Brenner; Peter T Campbell; Graham Casey; Andrew T Chan; Jenny Chang-Claude; David V Conti; Michelle Cotterchio; Dallas R English; Jane C Figueiredo; Graham G Giles; Edward L Giovannucci; Marc J Gunter; Jochen Hampe; Michael Hoffmeister; John L Hopper; Mark A Jenkins; Amit D Joshi; Loic Le Marchand; Mathieu Lemire; Christopher I Li; Li Li; Annika Lindblom; Vicente Martín; Victor Moreno; Polly A Newcomb; Kenneth Offit; Paul D P Pharoah; Gad Rennert; Lori C Sakoda; Clemens Schafmayer; Stephanie L Schmit; Martha L Slattery; Mingyang Song; Stephen N Thibodeau; Cornelia M Ulrich; Stephanie J Weinstein; Emily White; Aung Ko Win; Alicja Wolk; Michael O Woods; Anna H Wu; Qiuyin Cai; Joshua C Denny; Todd L Edwards; Harvey J Murff; Stephen B Gruber; Ulrike Peters; Wei Zheng
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2020-02-12       Impact factor: 4.090

  8 in total
  1 in total

1.  Systematic review of Mendelian randomization studies on risk of cancer.

Authors:  Georgios Markozannes; Afroditi Kanellopoulou; Olympia Dimopoulou; Dimitrios Kosmidis; Xiaomeng Zhang; Lijuan Wang; Evropi Theodoratou; Dipender Gill; Stephen Burgess; Konstantinos K Tsilidis
Journal:  BMC Med       Date:  2022-02-02       Impact factor: 11.150

  1 in total

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