Literature DB >> 32966533

Formation and manipulation of ferrofluid droplets with magnetic fields in a microdevice: a numerical parametric study.

Venoos Amiri Roodan1, Jenifer Gómez-Pastora2, Ioannis H Karampelas1, Cristina González-Fernández3, Eugenio Bringas3, Inmaculada Ortiz3, Jeffrey J Chalmers2, Edward P Furlani4, Mark T Swihart1.   

Abstract

We present a numerical model that describes the microfluidic generation and manipulation of ferrofluid droplets under an external magnetic field. We developed a numerical Computational Fluid Dynamics (CFD) analysis for predicting and optimizing continuous flow generation and processing of ferrofluid droplets with and without the presence of a permanent magnet. More specifically, we explore the dynamics of oil-based ferrofluid droplets within an aqueous continuous phase under an external inhomogeneous magnetic field. The developed model determines the effect of the magnetic field on the droplet generation, which is carried out in a flow-focusing geometry, and its sorting in T-junction channels. Three-channel depths (25 μm, 30 μm, and 40 μm) were investigated to study droplet deformation under magnetic forces. Among the three, the 30 μm channel depth showed the most consistent droplet production for the studied range of flow rates. Ferrofluids with different loadings of magnetic nanoparticles were used to observe the behavior for different ratios of magnetic and hydrodynamic forces. Our results show that the effect of these factors on droplet size and generation rate can be tuned and optimized to produce consistent droplet generation and sorting. This approach involves fully coupled magnetic-fluid mechanics models and can predict critical details of the process including droplet size, shape, trajectory, dispensing rate, and the perturbation of the fluid co-flow for different flow rates. The model enables better understanding of the physical phenomena involved in continuous droplet processing and allows efficient parametric analysis and optimization.

Entities:  

Year:  2020        PMID: 32966533      PMCID: PMC8256729          DOI: 10.1039/d0sm01426e

Source DB:  PubMed          Journal:  Soft Matter        ISSN: 1744-683X            Impact factor:   3.679


  19 in total

1.  Droplet microfluidics with magnetic beads: a new tool to investigate drug-protein interactions.

Authors:  Dario Lombardi; Petra S Dittrich
Journal:  Anal Bioanal Chem       Date:  2010-10-29       Impact factor: 4.142

2.  Magnetowetting and sliding motion of a sessile ferrofluid droplet in the presence of a permanent magnet.

Authors:  Nam-Trung Nguyen; Guiping Zhu; Yong-Chin Chua; Vinh-Nguyen Phan; Say-Hwa Tan
Journal:  Langmuir       Date:  2010-08-03       Impact factor: 3.882

3.  Electric control of droplets in microfluidic devices.

Authors:  Darren R Link; Erwan Grasland-Mongrain; Agnes Duri; Flavie Sarrazin; Zhengdong Cheng; Galder Cristobal; Manuel Marquez; David A Weitz
Journal:  Angew Chem Int Ed Engl       Date:  2006-04-10       Impact factor: 15.336

4.  Migration of ferrofluid droplets in shear flow under a uniform magnetic field.

Authors:  Jie Zhang; Md Rifat Hassan; Bhargav Rallabandi; Cheng Wang
Journal:  Soft Matter       Date:  2019-03-13       Impact factor: 3.679

Review 5.  Droplet based microfluidics.

Authors:  Ralf Seemann; Martin Brinkmann; Thomas Pfohl; Stephan Herminghaus
Journal:  Rep Prog Phys       Date:  2011-12-22

Review 6.  The power of solid supports in multiphase and droplet-based microfluidics: towards clinical applications.

Authors:  M Serra; D Ferraro; I Pereiro; J-L Viovy; S Descroix
Journal:  Lab Chip       Date:  2017-11-21       Impact factor: 6.799

7.  Shape evolution and splitting of ferrofluid droplets on a hydrophobic surface in the presence of a magnetic field.

Authors:  U Banerjee; A K Sen
Journal:  Soft Matter       Date:  2018-04-18       Impact factor: 3.679

8.  Computational modeling and fluorescence microscopy characterization of a two-phase magnetophoretic microsystem for continuous-flow blood detoxification.

Authors:  Jenifer Gómez-Pastora; Cristina González-Fernández; Eusebio Real; Alexander Iles; Eugenio Bringas; Edward P Furlani; Inmaculada Ortiz
Journal:  Lab Chip       Date:  2018-05-29       Impact factor: 6.799

9.  A circular ferrofluid driven microchip for rapid polymerase chain reaction.

Authors:  Y Sun; Y C Kwok; N T Nguyen
Journal:  Lab Chip       Date:  2007-06-13       Impact factor: 6.799

10.  On-chip polyelectrolyte coating onto magnetic droplets - towards continuous flow assembly of drug delivery capsules.

Authors:  Ali Q Alorabi; Mark D Tarn; Jenifer Gómez-Pastora; Eugenio Bringas; Inmaculada Ortiz; Vesselin N Paunov; Nicole Pamme
Journal:  Lab Chip       Date:  2017-11-07       Impact factor: 6.799

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