Paolo Florent Felisaz1,2, Eugenio Belatti1, Xeni Deligianni3,4, Niels Bergsland5,6, Francesco Santini7,8, Matteo Paoletti1, Francesca Solazzo1, Giancarlo Germani1, Andrea Cortese9,10, Elisa Vegezzi9, Oliver Bieri7,8, Stefano Bastianello1,9, Anna Pichiecchio1,9. 1. Department of Neuroradiology, IRCCS Mondino Foundation, Pavia, Italy. 2. Department of Radiology, Desio Hospital, ASST Monza, Desio, Italy. 3. Department of Radiology, Division of Radiological Physics, University Hospital Basel, Basel, Switzerland. xeni.deligianni@unibas.ch. 4. Department of Biomedical Engineering, University of Basel, Allschwil, Switzerland. xeni.deligianni@unibas.ch. 5. Department of Neurology, Buffalo Neuroimaging Analysis Center, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA. 6. IRCCS, Fondazione Don Carlo Gnocchi, Milan, Italy. 7. Department of Radiology, Division of Radiological Physics, University Hospital Basel, Basel, Switzerland. 8. Department of Biomedical Engineering, University of Basel, Allschwil, Switzerland. 9. Department of Brain and Behavioral Sciences, University of Pavia, Pavia, PV, Italy. 10. Department for Neuromuscular Disease, UCL Queen Square Institute of Neurology and The National Hospital for Neurology, London, UK.
Abstract
OBJECTIVE: The aim of this study was to develop and validate an MRI protocol based on a variable echo time (vTE) sensitive to the short T2* components of the sciatic nerve. MATERIALS AND METHODS: 15 healthy subjects (M/F: 9/6; age: 21-62) were scanned at 3T targeting the sciatic nerve at the thigh bilaterally, using a dual echo variable echo time (vTE) sequence (based on a spoiled gradient echo acquisition) with echo times of 0.98/5.37 ms. Apparent T2* (aT2*) values of the sciatic nerves were calculated with a mono-exponential fit and used for data comparison. RESULTS: There were no significant differences in aT2* related to side, sex, age, and BMI, even though small differences for side were reported. Good-to-excellent repeatability and reproducibility were found for geometry of ROIs (Dice indices: intra-rater 0.68-0.7; inter-rater 0.70-0.72) and the related aT2* measures (intra-inter reader ICC 0.95-0.97; 0.66-0.85) from two different operators. Side-related signal-to-noise-ratio non-significant differences were reported, while contrast-to-noise-ratio measures were excellent both for side and echo. DISCUSSION: Our study introduces a novel MR sequence sensitive to the short T2* components of the sciatic nerve and may be used for the study of peripheral nerve disorders.
OBJECTIVE: The aim of this study was to develop and validate an MRI protocol based on a variable echo time (vTE) sensitive to the short T2* components of the sciatic nerve. MATERIALS AND METHODS: 15 healthy subjects (M/F: 9/6; age: 21-62) were scanned at 3T targeting the sciatic nerve at the thigh bilaterally, using a dual echo variable echo time (vTE) sequence (based on a spoiled gradient echo acquisition) with echo times of 0.98/5.37 ms. Apparent T2* (aT2*) values of the sciatic nerves were calculated with a mono-exponential fit and used for data comparison. RESULTS: There were no significant differences in aT2* related to side, sex, age, and BMI, even though small differences for side were reported. Good-to-excellent repeatability and reproducibility were found for geometry of ROIs (Dice indices: intra-rater 0.68-0.7; inter-rater 0.70-0.72) and the related aT2* measures (intra-inter reader ICC 0.95-0.97; 0.66-0.85) from two different operators. Side-related signal-to-noise-ratio non-significant differences were reported, while contrast-to-noise-ratio measures were excellent both for side and echo. DISCUSSION: Our study introduces a novel MR sequence sensitive to the short T2* components of the sciatic nerve and may be used for the study of peripheral nerve disorders.
Entities:
Keywords:
Fibrosis; Magnetic resonance imaging; Peripheral nerves; Validation study
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