Literature DB >> 32962408

Role of age and neuroinflammation in the mechanism of cognitive deficits in sickle cell disease.

Raven A Hardy1,2, Noor Abi Rached3, Jayre A Jones4,5, David R Archer2,4,5, Hyacinth I Hyacinth1,2,4,5.   

Abstract

IMPACT STATEMENT: This study provides crucial information that could be helpful in the development of new or repurposing of existing therapies for the treatment of cognitive deficit in individuals with sickle cell disease (SCD). Its impact is in demonstrating for the first time that neuroinflammation and along with abnormal neuroplasticity are among the underlying mechanism of cognitive and behavioral deficits in SCD and that drugs such as minocycline which targets these pathophysiological mechanisms could be repurposed for the treatment of this life altering complication of SCD.

Entities:  

Keywords:  Sickle cell disease; cognitive impairment; neuroinflammation; neuroplasticity; neuroscience

Mesh：

Substances：

Year:  2020        PMID： 32962408      PMCID： PMC7797997          DOI： 10.1177/1535370220958011

Source DB:  PubMed          Journal:  Exp Biol Med (Maywood)        ISSN： 1535-3699


  87 in total

1.  Neuroprotective mechanisms of minocycline against sphingomyelinase/ceramide toxicity: Roles of Bcl-2 and thioredoxin.

Authors:  Ching-Min Tang; Chi-Shin Hwang; Shang-Der Chen; Ding-I Yang
Journal:  Free Radic Biol Med       Date:  2010-12-22       Impact factor: 7.376

2.  Cognitive deficits are associated with unemployment in adults with sickle cell anemia.

Authors:  Maureen Sanger; Lori Jordan; Sumit Pruthi; Matthew Day; Brittany Covert; Brenda Merriweather; Mark Rodeghier; Michael DeBaun; Adetola Kassim
Journal:  J Clin Exp Neuropsychol       Date:  2016-08       Impact factor: 2.475

3.  Silent cerebral infarcts and cerebral aneurysms are prevalent in adults with sickle cell anemia.

Authors:  Adetola A Kassim; Sumit Pruthi; Matthew Day; Mark Rodeghier; Melissa C Gindville; Max A Brodsky; Michael R DeBaun; Lori C Jordan
Journal:  Blood       Date:  2016-03-03       Impact factor: 22.113

Review 4.  Sex differences in neuroinflammation and neuroprotection in ischemic stroke.

Authors:  Monica S Spychala; Pedram Honarpisheh; Louise D McCullough
Journal:  J Neurosci Res       Date:  2017-01-02       Impact factor: 4.164

5.  Cognitive and behavior deficits in sickle cell mice are associated with profound neuropathologic changes in hippocampus and cerebellum.

Authors:  Li Wang; Luis E F Almeida; Celia M de Souza Batista; Alfia Khaibullina; Nuo Xu; Sarah Albani; Kira A Guth; Ji Sung Seo; Martha Quezado; Zenaide M N Quezado
Journal:  Neurobiol Dis       Date:  2015-10-14       Impact factor: 5.996

6.  Dendritic spines provide cognitive resilience against Alzheimer's disease.

Authors:  Benjamin D Boros; Kelsey M Greathouse; Erik G Gentry; Kendall A Curtis; Elizabeth L Birchall; Marla Gearing; Jeremy H Herskowitz
Journal:  Ann Neurol       Date:  2017-10-22       Impact factor: 10.422

7.  Bisphenol-A exposure during adolescence leads to enduring alterations in cognition and dendritic spine density in adult male and female rats.

Authors:  Rachel E Bowman; Victoria Luine; Samantha Diaz Weinstein; Hameda Khandaker; Sarah DeWolf; Maya Frankfurt
Journal:  Horm Behav       Date:  2014-12-30       Impact factor: 3.587

8.  PROMIS(®) pediatric self-report scales distinguish subgroups of children within and across six common pediatric chronic health conditions.

Authors:  Darren A DeWalt; Heather E Gross; Debbie S Gipson; David T Selewski; Esi Morgan DeWitt; Carlton D Dampier; Pamela S Hinds; I-Chan Huang; David Thissen; James W Varni
Journal:  Qual Life Res       Date:  2015-02-26       Impact factor: 4.147

Review 9.  Normal cognitive aging.

Authors:  Caroline N Harada; Marissa C Natelson Love; Kristen L Triebel
Journal:  Clin Geriatr Med       Date:  2013-11       Impact factor: 3.076

10.  Longitudinal in vivo imaging reveals balanced and branch-specific remodeling of mature cortical pyramidal dendritic arbors after stroke.

Authors:  Craig E Brown; Jamie D Boyd; Timothy H Murphy
Journal:  J Cereb Blood Flow Metab       Date:  2009-11-18       Impact factor: 6.200
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  2 in total

Review 1.  Sickle cell disease as an accelerated aging syndrome.

Authors:  Ibrahim M Idris; Edward A Botchwey; Hyacinth I Hyacinth
Journal:  Exp Biol Med (Maywood)       Date:  2022-02-16

Review 2.  Perspectives on Cognitive Phenotypes and Models of Vascular Disease.

Authors:  Selen C Muratoglu; Marc F Charette; Stacey J Sukoff Rizzo; M Luisa Iruela-Arispe; Zorina S Galis; Adam S Greenstein; Alan Daugherty; Anne Joutel; Beth A Kozel; Donna M Wilcock; Emily C Collins; Farzaneh A Sorond; Gareth R Howell; Hyacinth I Hyacinth; Kent K C Lloyd; Kurt R Stenmark; Manfred Boehm; Mark L Kahn; Roderick Corriveau; Sara Wells; Timothy J Bussey
Journal:  Arterioscler Thromb Vasc Biol       Date:  2022-05-05       Impact factor: 10.514
  2 in total

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