P Quitadamo1,2, L Zenzeri3, E Mozzillo4, V Giorgio5, A Rocco6, A Franzese4, G Nardone6, A Staiano4. 1. Department of Translational Medical Science, Section of Pediatrics, "Federico II" University of Naples, Naples, Italy. paoloquitadamo@yahoo.it. 2. Department of Pediatrics, A.O.R.N. Santobono-Pausilipon, Via Mario Fiore 6, 80129, Naples, Italy. paoloquitadamo@yahoo.it. 3. Department of Pediatrics, University of Perugia, Perugia, Italy. 4. Department of Translational Medical Science, Section of Pediatrics, "Federico II" University of Naples, Naples, Italy. 5. UOC Pediatria, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy. 6. Department of Gastroenterology, "Federico II" University of Naples, Naples, Italy.
Abstract
PURPOSE: The main aim of the study was to assess the relationship between leptin, ghrelin, insulin-like growth factor 1 (IGF-1), and glucagon-like peptide 1 (GLP-1) blood levels and gastric motility in children with obesity compared to healthy children. Secondary aims were to assess the possible association between these hormones and obesity, reflux impedance parameters, reflux symptoms, other GI disorders, and quality-of-life scores within the same groups. METHODS: Children with obesity plus GERD symptoms and 2 control groups of children with obesity without GERD and healthy lean children aged 4-17 years underwent an auxological evaluation, an assessment of gastro-intestinal symptoms and quality of life, hormonal dosages, and an evaluation of gastric emptying time (GET) through 13C-octanoic acid breath test. RESULTS: No significant association was found between hormones and gastric motility. Leptin and ghrelin levels were significantly associated with obesity parameters. No significant differences were found between GET and hormones of the patients with obesity, either with or without GERD. CONCLUSION: Although we found an association between auxological parameters and both leptin and ghrelin levels, this association did not imply an effect on the upper GI motility. Therefore, our hypothesis that alterations of these hormones in children with obesity could affect gastric emptying, triggering GERD, was not supported by our data.
PURPOSE: The main aim of the study was to assess the relationship between leptin, ghrelin, insulin-like growth factor 1 (IGF-1), and glucagon-like peptide 1 (GLP-1) blood levels and gastric motility in children with obesity compared to healthy children. Secondary aims were to assess the possible association between these hormones and obesity, reflux impedance parameters, reflux symptoms, other GI disorders, and quality-of-life scores within the same groups. METHODS:Children with obesity plus GERD symptoms and 2 control groups of children with obesity without GERD and healthy lean children aged 4-17 years underwent an auxological evaluation, an assessment of gastro-intestinal symptoms and quality of life, hormonal dosages, and an evaluation of gastric emptying time (GET) through 13C-octanoic acid breath test. RESULTS: No significant association was found between hormones and gastric motility. Leptin and ghrelin levels were significantly associated with obesity parameters. No significant differences were found between GET and hormones of the patients with obesity, either with or without GERD. CONCLUSION: Although we found an association between auxological parameters and both leptin and ghrelin levels, this association did not imply an effect on the upper GI motility. Therefore, our hypothesis that alterations of these hormones in children with obesity could affect gastric emptying, triggering GERD, was not supported by our data.
Authors: Mohammad H Derakhshan; Elaine V Robertson; Jonathan Fletcher; Gareth-Rhys Jones; Yeong Yeh Lee; Angela A Wirz; Kenneth E L McColl Journal: Gut Date: 2011-08-28 Impact factor: 23.059
Authors: Markus Juonala; Costan G Magnussen; Gerald S Berenson; Alison Venn; Trudy L Burns; Matthew A Sabin; Sathanur R Srinivasan; Stephen R Daniels; Patricia H Davis; Wei Chen; Cong Sun; Michael Cheung; Jorma S A Viikari; Terence Dwyer; Olli T Raitakari Journal: N Engl J Med Date: 2011-11-17 Impact factor: 91.245
Authors: Ram Weiss; James Dziura; Tania S Burgert; William V Tamborlane; Sara E Taksali; Catherine W Yeckel; Karin Allen; Melinda Lopes; Mary Savoye; John Morrison; Robert S Sherwin; Sonia Caprio Journal: N Engl J Med Date: 2004-06-03 Impact factor: 91.245