Francesco Giganti1,2, Vasilis Stavrinides2,3, Armando Stabile4, Elizabeth Osinibi2, Clement Orczyk2,3, Jan Philipp Radtke5, Alex Freeman6, Aiman Haider6, Shonit Punwani1,7, Clare Allen1, Mark Emberton2,3, Alex Kirkham1, Caroline M Moore2,3. 1. Department of Radiology, University College London Hospital NHS Foundation Trust, London, UK. 2. Division of Surgery & Interventional Science, University College London, London, UK. 3. Department of Urology, University College London Hospital NHS Foundation Trust, London, UK. 4. Department of Urology and Division of Experimental Oncology, Vita-Salute San Raffaele University, Milan, Italy. 5. Department of Urology, University Hospital Essen, Essen, Germany. 6. Department of Pathology, University College London Hospital NHS Foundation Trust, London, UK. 7. Centre for Medical Imaging, University College London, London, UK.
Abstract
OBJECTIVE: The PRECISE criteria for reporting multiparametric MRI in patients on active surveillance (AS) for prostate cancer (PCa) score the likelihood of clinically significant change over time using a 1-5 scale, where 4 or 5 indicates radiological progression. According to the PRECISE recommendations, the index lesion size can be reported using different definitions of volume (planimetry or ellipsoid formula) or by measuring one or two diameters. We compared different measurements using planimetry as the reference standard and stratified changes according to the PRECISE scores. METHODS: We retrospectively analysed 196 patients on AS with PCa confirmed by targeted biopsy who had two MR scans (baseline and follow-up). Lesions were measured on T2 weighted imaging (T2WI) according to all definitions. A PRECISE score was assessed for each patient. RESULTS: The ellipsoid formula exhibited the highest correlation with planimetry at baseline (ρ = 0.97) and follow-up (ρ = 0.98) imaging, compared to the biaxial measurement and single maximum diameter. There was a significant difference (p < 0.001) in the yearly percentage volume change between radiological regression/stability (PRECISE 2-3) and progression (PRECISE 4-5) for planimetry (39.64%) and for the ellipsoid formula (46.78%). CONCLUSION: The ellipsoid formula could be used to monitor tumour growth during AS. Evidence of a significant yearly percentage volume change between radiological regression/stability (PRECISE 2-3) and progression (PRECISE 4-5) has been also observed. ADVANCES IN KNOWLEDGE: The ellipsoid formula is a reasonable surrogate for planimetry in capturing tumour volume changes on T2WI in patients on imaging-led AS. This is also associated with radiological changes using the PRECISE recommendations.
OBJECTIVE: The PRECISE criteria for reporting multiparametric MRI in patients on active surveillance (AS) for prostate cancer (PCa) score the likelihood of clinically significant change over time using a 1-5 scale, where 4 or 5 indicates radiological progression. According to the PRECISE recommendations, the index lesion size can be reported using different definitions of volume (planimetry or ellipsoid formula) or by measuring one or two diameters. We compared different measurements using planimetry as the reference standard and stratified changes according to the PRECISE scores. METHODS: We retrospectively analysed 196 patients on AS with PCa confirmed by targeted biopsy who had two MR scans (baseline and follow-up). Lesions were measured on T2 weighted imaging (T2WI) according to all definitions. A PRECISE score was assessed for each patient. RESULTS: The ellipsoid formula exhibited the highest correlation with planimetry at baseline (ρ = 0.97) and follow-up (ρ = 0.98) imaging, compared to the biaxial measurement and single maximum diameter. There was a significant difference (p < 0.001) in the yearly percentage volume change between radiological regression/stability (PRECISE 2-3) and progression (PRECISE 4-5) for planimetry (39.64%) and for the ellipsoid formula (46.78%). CONCLUSION: The ellipsoid formula could be used to monitor tumour growth during AS. Evidence of a significant yearly percentage volume change between radiological regression/stability (PRECISE 2-3) and progression (PRECISE 4-5) has been also observed. ADVANCES IN KNOWLEDGE: The ellipsoid formula is a reasonable surrogate for planimetry in capturing tumour volume changes on T2WI in patients on imaging-led AS. This is also associated with radiological changes using the PRECISE recommendations.
Authors: Francesco Giganti; Caroline M Moore; Shonit Punwani; Clare Allen; Mark Emberton; Alex Kirkham Journal: Prostate Cancer Prostatic Dis Date: 2018-07-23 Impact factor: 5.554
Authors: Francesco Giganti; Clare Allen; Jonathan W Piper; David Mirando; Armando Stabile; Shonit Punwani; Alex Kirkham; Mark Emberton; Caroline M Moore Journal: Magn Reson Imaging Date: 2018-10-20 Impact factor: 2.546
Authors: J J Knoedler; R J Karnes; R H Thompson; L J Rangel; E J Bergstralh; S A Boorjian Journal: Prostate Cancer Prostatic Dis Date: 2014-01-28 Impact factor: 5.554
Authors: Francesco Giganti; Alex Kirkham; Clare Allen; Shonit Punwani; Clément Orczyk; Mark Emberton; Caroline M Moore Journal: AJR Am J Roentgenol Date: 2021-02-03 Impact factor: 3.959
Authors: Yousef Mazaheri; Hedvig Hricak; Samson W Fine; Oguz Akin; Amita Shukla-Dave; Nicole M Ishill; Chaya S Moskowitz; Joanna E Grater; Victor E Reuter; Kristen L Zakian; Karim A Touijer; Jason A Koutcher Journal: Radiology Date: 2009-08 Impact factor: 11.105
Authors: Baris Turkbey; Andrew B Rosenkrantz; Masoom A Haider; Anwar R Padhani; Geert Villeirs; Katarzyna J Macura; Clare M Tempany; Peter L Choyke; Francois Cornud; Daniel J Margolis; Harriet C Thoeny; Sadhna Verma; Jelle Barentsz; Jeffrey C Weinreb Journal: Eur Urol Date: 2019-03-18 Impact factor: 20.096
Authors: Vasilis Stavrinides; Francesco Giganti; Bruce Trock; Shonit Punwani; Clare Allen; Alex Kirkham; Alex Freeman; Aiman Haider; Rhys Ball; Neil McCartan; Hayley Whitaker; Clement Orczyk; Mark Emberton; Caroline M Moore Journal: Eur Urol Date: 2020-04-30 Impact factor: 20.096
Authors: Caroline M Moore; Francesco Giganti; Peter Albertsen; Clare Allen; Chris Bangma; Alberto Briganti; Peter Carroll; Masoom Haider; Veeru Kasivisvanathan; Alex Kirkham; Laurence Klotz; Adil Ouzzane; Anwar R Padhani; Valeria Panebianco; Peter Pinto; Philippe Puech; Antti Rannikko; Raphaele Renard-Penna; Karim Touijer; Baris Turkbey; Heinrik van Poppel; Riccardo Valdagni; Jochen Walz; Ivo Schoots Journal: Eur Urol Date: 2016-06-24 Impact factor: 20.096