Takuma Minami1, Takeshi Matsumoto1,2, Yasuharu Tabara3, David Gozal4, Dale Smith5, Kimihiko Murase6, Kiminobu Tanizawa1, Naomi Takahashi6, Yoshinari Nakatsuka6, Satoshi Hamada7, Tomohiro Handa7, Hirofumi Takeyama6, Toru Oga8, Isuzu Nakamoto9, Tomoko Wakamura9, Naoko Komenami10, Kazuya Setoh3, Takanobu Tsutsumi3, Takahisa Kawaguchi3, Yoichiro Kamatani11, Yoshimitsu Takahashi12, Satoshi Morita13, Takeo Nakayama12, Toyohiro Hirai1, Fumihiko Matsuda3, Kazuo Chin6. 1. Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan. 2. Department of Respiratory Medicine, Osaka Saiseikai Noe Hospital, Osaka, Japan. 3. Center for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan. 4. Department of Child Health and Child Health Research Institute, University of Missouri School of Medicine, Columbia, Missouri. 5. Department of Behavioral Sciences, Olivet Nazarene University, Bourbonnais, Illinois. 6. Department of Respiratory Care and Sleep Control Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan. 7. Department of Advance Medicine for Respiratory Failure, Graduate School of Medicine, Kyoto University, Kyoto, Japan. 8. Department of Respiratory Medicine, Kawasaki Medical School, Kurashiki, Japan. 9. Nursing Science, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan. 10. Department of Food and Nutrition, Kyoto Women's University, Kyoto, Japan. 11. Kyoto-McGill International Collaborative School in Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan. 12. Department of Health Informatics, Kyoto University School of Public Health, Kyoto, Japan. 13. Department of Biomedical Statistics and Bioinformatics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Abstract
STUDY OBJECTIVES: It is well known that a family history of diabetes (FHD) is a definitive risk factor for type 2 diabetes. It has not been known whether sleep-disordered breathing (SDB) increases the prevalence of diabetes in those with an FHD. METHODS: We assessed SDB severity in 7,477 study participants by oximetry corrected by objective sleep duration determined by wrist actigraphy. Glycated hemoglobin ≥6.5% and/or current medication for diabetes indicated the presence of diabetes. In addition to the overall prevalence, the prevalence of recent-onset diabetes during the nearly 5 years before the SDB measurements were made was investigated. RESULTS: Of the 7,477 participants (mean age: 57.9; range: 34.2-80.7; SD: 12.1 years; 67.7% females), 1,569 had an FHD. The prevalence of diabetes in FHD participants with moderate-to-severe SDB (MS-SDB) was higher than in those without SDB (MS-SDB vs without SDB: all, 29.3% vs 3.3% [P < .001]; females, 32.6% vs 1.9% [P < .001]; males, 26.2% vs 11.7% [P = .037]). However, multivariate analysis showed that MS-SDB was significantly associated with a higher prevalence of diabetes only in FHD-positive females (odds ratio [95% confidence interval]: females, 7.43 [3.16-17.45]; males, 0.92 [0.37-2.31]). Among the FHD-positive participants, the prevalence of recent-onset diabetes was higher in those with MS-SDB than those without SDB, but only in females (MS-SDB vs without SDB: 21.4% vs 1.1%; P < 0.001). CONCLUSIONS: MS-SDB was associated with diabetes risk in females with an FHD, and future studies are needed on whether treatment of SDB in females with an FHD would prevent the onset of diabetes.
STUDY OBJECTIVES: It is well known that a family history of diabetes (FHD) is a definitive risk factor for type 2 diabetes. It has not been known whether sleep-disordered breathing (SDB) increases the prevalence of diabetes in those with an FHD. METHODS: We assessed SDB severity in 7,477 study participants by oximetry corrected by objective sleep duration determined by wrist actigraphy. Glycated hemoglobin ≥6.5% and/or current medication for diabetes indicated the presence of diabetes. In addition to the overall prevalence, the prevalence of recent-onset diabetes during the nearly 5 years before the SDB measurements were made was investigated. RESULTS: Of the 7,477 participants (mean age: 57.9; range: 34.2-80.7; SD: 12.1 years; 67.7% females), 1,569 had an FHD. The prevalence of diabetes in FHD participants with moderate-to-severe SDB (MS-SDB) was higher than in those without SDB (MS-SDB vs without SDB: all, 29.3% vs 3.3% [P < .001]; females, 32.6% vs 1.9% [P < .001]; males, 26.2% vs 11.7% [P = .037]). However, multivariate analysis showed that MS-SDB was significantly associated with a higher prevalence of diabetes only in FHD-positive females (odds ratio [95% confidence interval]: females, 7.43 [3.16-17.45]; males, 0.92 [0.37-2.31]). Among the FHD-positive participants, the prevalence of recent-onset diabetes was higher in those with MS-SDB than those without SDB, but only in females (MS-SDB vs without SDB: 21.4% vs 1.1%; P < 0.001). CONCLUSIONS: MS-SDB was associated with diabetes risk in females with an FHD, and future studies are needed on whether treatment of SDB in females with an FHD would prevent the onset of diabetes.
Authors: Jessie P Bakker; Jia Weng; Rui Wang; Susan Redline; Naresh M Punjabi; Sanjay R Patel Journal: Am J Respir Crit Care Med Date: 2015-09-15 Impact factor: 21.405
Authors: Mary S M Ip; Bing Lam; Matthew M T Ng; Wah Kit Lam; Kenneth W T Tsang; Karen S L Lam Journal: Am J Respir Crit Care Med Date: 2002-03-01 Impact factor: 21.405