Erratum to dexmedetomidine promotes breast cancer cell migration through Rab11-mediated secretion of exosomal TMPRSS2.

[This corrects the article DOI: 10.21037/atm.2020.04.28.]. 2020 Annals of Translational Medicine. All rights reserved.

Dexmedetomidine promotes breast cancer cell migration through Rab11-mediated secretion of exosomal TMPRSS2

In the April 2020 issue of Annals of Translational Medicine, the paper “Dexmedetomidine promotes breast cancer cell migration through Rab11-mediated secretion of exosomal TMPRSS2” by Dr. Chi et al. (1) was published with some errors concerning the figures and should be corrected as follow.

In the left part of Figure 2B, “DEX” was missed and it should be added between “CTL” and “DEX + siCTL” while the legend for Figure 2B remains correct. In Figure 2C, the “#” should be removed, and accordingly the words “#, P<0.05” in the figure legend should be deleted. So the Figure 2B and Figure 2C should be corrected as below:

Corrected legend for Figure 2C: (C) Scratch assay was performed in DEX-treated MCF-7 that expressed siTMP-b. DEX-induced increase of migration was prevented by the siTMP-b. Magnification ×20 for all panels. Data are presented as mean ± SD. The experiment was carried out independently in triplicate. *, P<0.05; **, P<0.01; ***, P<0.001.

In Figure 3E, the “##” should be removed from the left graph and the words “##, P<0.01” in the figure legend should be accordingly deleted. So the Figure 3E should be corrected as below:

Corrected legend for Figure 3E: (E) MCF-7 was pretreated for 1 h with 10 µM of WP1066 followed by incubation for 48 h with 1 µM of DEX. Total cellular protein was extracted, and Western blot assay was performed to detect the expressions of full-length (arrowhead) and the cleaved protease domain (arrow) of TMPRSS2. Data are presented as the mean ± SD. The experiment was conducted independently in triplicate. *, P<0.05; **, P<0.01; ***, P<0.001.

In Figure 4B, the “***” was missed in the middle graph and it has been added. So, the Figure 4B should be corrected as below:

In Figure S3B, the blot for TMPRSS2 in the Cell lysates fraction was missed and it has been added. So the Figure S3B should be corrected as below:

The authors regret the errors and all inconveniences caused.