Jun Hyuk Lee1, Ji Young Lee2, Ho Ra1, Nam Yeo Kang1, Jiwon Baek1. 1. Department of Ophthalmology, Bucheon St. Mary's Hospital, College of Medicine, the Catholic University of Korea, Gyeonggi-do 14647, Republic of Korea. 2. Department of Ophthalmology, Yeoeuido St. Mary's Hospital, College of Medicine, the Catholic University of Korea, Seoul 06591, Republic of Korea.
Abstract
AIM: To analyze the effect of systemic high-dose corticosteroid on the choroid in patients with unilateral optic neuritis. METHODS: A retrospective comparative cohort study. Seventy-six eyes of 38 patients with unilateral optic neuritis that received systemic high-dose corticosteroid treatment were enrolled. Choroidal thickness (CT) and choroidal vascularity index (CVI) were measured in both affected and the fellow eyes at baseline, 1wk, 1 and 3mo. Changes in CT and CVI were analyzed in both eyes and compared between eyes. RESULTS: The mean CT and CVI were 349 µm and 0.70 in the affected eyes and 340 µm and 0.69 in the fellow eyes at baseline (P=0.503 and 0.440, respectively). Decrement of CT and CVI at month 3 were significant in affected eyes (P=0.017 and P<0.001). Decreased CVI began 2wk after treatment whereas CT decreased from 1mo. The CVI also decreased significantly in fellow eyes at 3mo compared to the baseline (P=0.001). CONCLUSION: A significant decrement in CT and CVI can appear after 3mo in optic neuritis patients treated with high-dose systemic corticosteroid treatment. The decrease in CVI appeared earlier than the decrease in CT, suggesting choroidal vasoconstriction caused by systemic steroid as a possible mechanism. International Journal of Ophthalmology Press.
AIM: To analyze the effect of systemic high-dose corticosteroid on the choroid in patients with unilateral optic neuritis. METHODS: A retrospective comparative cohort study. Seventy-six eyes of 38 patients with unilateral optic neuritis that received systemic high-dose corticosteroid treatment were enrolled. Choroidal thickness (CT) and choroidal vascularity index (CVI) were measured in both affected and the fellow eyes at baseline, 1wk, 1 and 3mo. Changes in CT and CVI were analyzed in both eyes and compared between eyes. RESULTS: The mean CT and CVI were 349 µm and 0.70 in the affected eyes and 340 µm and 0.69 in the fellow eyes at baseline (P=0.503 and 0.440, respectively). Decrement of CT and CVI at month 3 were significant in affected eyes (P=0.017 and P<0.001). Decreased CVI began 2wk after treatment whereas CT decreased from 1mo. The CVI also decreased significantly in fellow eyes at 3mo compared to the baseline (P=0.001). CONCLUSION: A significant decrement in CT and CVI can appear after 3mo in optic neuritispatients treated with high-dose systemic corticosteroid treatment. The decrease in CVI appeared earlier than the decrease in CT, suggesting choroidal vasoconstriction caused by systemic steroid as a possible mechanism. International Journal of Ophthalmology Press.
Authors: R F Spaide; L Hall; A Haas; L Campeas; L A Yannuzzi; Y L Fisher; D R Guyer; J S Slakter; J A Sorenson; D A Orlock Journal: Retina Date: 1996 Impact factor: 4.256
Authors: Jeong Mo Han; Jeong-Min Hwang; Ji Soo Kim; Kyu Hyung Park; Se Joon Woo Journal: Invest Ophthalmol Vis Sci Date: 2014-01-21 Impact factor: 4.799