Literature DB >> 32951747

One man's swordfish story: The link between Alzheimer's disease and mercury exposure.

Madeline M Foley1, Ilana Seidel2, Justin Sevier3, Julie Wendt4, Mikhail Kogan5.   

Abstract

It is well-documented that when mercury levels surpass the permissible value, individuals experience a myriad of symptoms that include chronic fatigue, dizziness, and loss of appetite. Mercury is also known to be one of the most potent neurotoxins. This case study depicts a 91- year-old who presented with cognitive decline diagnosed as Alzheimer's disease. This patient was found to have severely elevated mercury levels caused by consuming high mercury containing fish. Following diet adjustment and detoxification, this patient's cognitive impairment significantly improved in proportion to the decline in methylmercury level. One year later, his cognition and functional status rapidly and unexpectedly declined. A computed tomography (CT) scan revealed multiple new lacunar subacute strokes. Thus, it is critical to address biological etiologies such as mercury toxicity in the elderly population diagnosed with Alzheimer's, but end organ damage may not be reversible.
Copyright © 2020. Published by Elsevier Ltd.

Entities:  

Keywords:  Alzheimer’s disease; Cognitive decline; Mercury

Mesh:

Substances:

Year:  2020        PMID: 32951747     DOI: 10.1016/j.ctim.2020.102499

Source DB:  PubMed          Journal:  Complement Ther Med        ISSN: 0965-2299            Impact factor:   2.446


  4 in total

1.  Genetic Polymorphism of Delta Aminolevulinic Acid Dehydratase (ALAD) Gene and Symptoms of Chronic Mercury Exposure in Munduruku Indigenous Children within the Brazilian Amazon.

Authors:  Jamila Alessandra Perini; Mayara Calixto Silva; Ana Claudia Santiago de Vasconcellos; Paulo Victor Sousa Viana; Marcelo Oliveira Lima; Iracina Maura Jesus; Joseph William Kempton; Rogério Adas Ayres Oliveira; Sandra Souza Hacon; Paulo Cesar Basta
Journal:  Int J Environ Res Public Health       Date:  2021-08-19       Impact factor: 3.390

2.  Heavy metals and adult neurogenesis.

Authors:  Hao Wang; Megumi T Matsushita
Journal:  Curr Opin Toxicol       Date:  2021-04-07

3.  Methylmercury Impact on Adult Neurogenesis: Is the Worst Yet to Come From Recent Brazilian Environmental Disasters?

Authors:  Ramon da Silva Raposo; Daniel Vieira Pinto; Ricardo Moreira; Ronaldo Pereira Dias; Carlos Alberto Fontes Ribeiro; Reinaldo Barreto Oriá; João Oliveira Malva
Journal:  Front Aging Neurosci       Date:  2020-11-23       Impact factor: 5.750

4.  BMAA, Methylmercury, and Mechanisms of Neurodegeneration in Dolphins: A Natural Model of Toxin Exposure.

Authors:  David A Davis; Susanna P Garamszegi; Sandra Anne Banack; Patrick D Dooley; Thomas M Coyne; Dylan W McLean; David S Rotstein; Deborah C Mash; Paul Alan Cox
Journal:  Toxins (Basel)       Date:  2021-10-01       Impact factor: 4.546

  4 in total

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