Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Mice Are Not Humans: The Case of p53.

Literature DB >> 32950424

Mice Are Not Humans: The Case of p53.

Abstract

Mouse models represent powerful tools in cancer research that have influenced much of our understanding of tumor development and our current anticancer strategies. Yet, central signaling pathways differ considerably between mouse and human, including gene regulatory networks (GRNs) of the most important tumor suppressor p53 and its oncogenic sibling p63.

Entities: Disease Gene Species

Keywords: cancer research; evolution; gene regulatory networks; mouse models; p53; p63

Year: 2020 PMID： 32950424 DOI： 10.1016/j.trecan.2020.08.007

Source DB: PubMed Journal: Trends Cancer ISSN： 2405-8025

Keyword Cloud
Cited

8 in total

1. The Centriole's Role in Miscarriages.

Authors: Tomer Avidor-Reiss; Luke Achinger; Rustem Uzbekov
Journal: Front Cell Dev Biol Date: 2022-03-01

2. Charting oncogenicity of genes and variants across lineages via multiplexed screens in teratomas.

Authors: Udit Parekh; Daniella McDonald; Amir Dailamy; Yan Wu; Thekla Cordes; Kun Zhang; Ann Tipps; Christian Metallo; Prashant Mali
Journal: iScience Date: 2021-09-20

Review 3. Emerging Mechanisms of G₁/S Cell Cycle Control by Human and Mouse Cytomegaloviruses.

Authors: Boris Bogdanow; Quang Vinh Phan; Lüder Wiebusch
Journal: mBio Date: 2021-12-14 Impact factor: 7.867

4. Direct cellular reprogramming enables development of viral T antigen-driven Merkel cell carcinoma in mice.

Authors: Monique E Verhaegen; Paul W Harms; Julia J Van Goor; Jacob Arche; Matthew T Patrick; Dawn Wilbert; Haley Zabawa; Marina Grachtchouk; Chia-Jen Liu; Kevin Hu; Michael C Kelly; Ping Chen; Thomas L Saunders; Stephan Weidinger; Li-Jyun Syu; John S Runge; Johann E Gudjonsson; Sunny Y Wong; Isaac Brownell; Marcin Cieslik; Aaron M Udager; Arul M Chinnaiyan; Lam C Tsoi; Andrzej A Dlugosz
Journal: J Clin Invest Date: 2022-04-01 Impact factor: 14.808

Mice Are Not Humans: The Case of p53.

1. The Centriole's Role in Miscarriages.

2. Charting oncogenicity of genes and variants across lineages via multiplexed screens in teratomas.

Review 3. Emerging Mechanisms of G₁/S Cell Cycle Control by Human and Mouse Cytomegaloviruses.

4. Direct cellular reprogramming enables development of viral T antigen-driven Merkel cell carcinoma in mice.

5. TargetGeneReg 2.0: a comprehensive web-atlas for p53, p63, and cell cycle-dependent gene regulation.

6. p53-mediated AKT and mTOR inhibition requires RFX7 and DDIT4 and depends on nutrient abundance.

Review 7. Drugging p53 in cancer: one protein, many targets.

Review 8. Mouse models for mesothelioma drug discovery and development.

Mice Are Not Humans: The Case of p53.

1. The Centriole's Role in Miscarriages.

2. Charting oncogenicity of genes and variants across lineages via multiplexed screens in teratomas.

Review 3. Emerging Mechanisms of G1/S Cell Cycle Control by Human and Mouse Cytomegaloviruses.

4. Direct cellular reprogramming enables development of viral T antigen-driven Merkel cell carcinoma in mice.

5. TargetGeneReg 2.0: a comprehensive web-atlas for p53, p63, and cell cycle-dependent gene regulation.

6. p53-mediated AKT and mTOR inhibition requires RFX7 and DDIT4 and depends on nutrient abundance.

Review 7. Drugging p53 in cancer: one protein, many targets.

Review 8. Mouse models for mesothelioma drug discovery and development.

Review 3. Emerging Mechanisms of G₁/S Cell Cycle Control by Human and Mouse Cytomegaloviruses.