Savaş Sipahi1, Hamad Dheir1, Aysel Toçoğlu2, Melike Bektaş2, Seyyid Bilal Açıkgöz3, Ahmed Cihad Genç2, Fuldem Mutlu4, Mehmet Köroğlu5, Ali Fuat Erdem6, Oğuz Karabay7. 1. Department of Internal Medicine, Division of Nephrology, Faculty of Medicine, Sakarya University, Sakarya, Turkey 2. Department of Internal Medicine, Faculty of Medicine, Sakarya University, Sakarya, Turkey 3. Department of Internal Medicine, Faculty of Medicine, 19 Mayıs University, Samsun, Turkey 4. Department of Radiology, Faculty of Medicine, Sakarya University, Sakarya, Turkey 5. Department of Microbiology, Faculty of Medicine, Sakarya University, Sakarya, Turkey 6. Department of Anaesthesiology, Faculty of Medicine, Sakarya University, Sakarya, Turkey 7. Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Sakarya University, Sakarya, Turkey
Abstract
Background/aim: The COVID-19 infection, which started in Wuhan City, China, in December 2019, turned into a pandemic in a very short time, affecting mainly the elderly and those with serious chronic illnesses. COVID-19 infections have been observed to have a high mortality rate, especially in patients undergoing maintenance hemodialysis. Materials and methods: Forty-two patients over 18 years of age who underwent a maintenance hemodialysis program at our unit, who tested positive for COVID-19 by PCR from nasopharyngeal swabs, and/or who were observed to have disease-related signs in their CTs were included in the study. Results: In this study, 23 of 42 patients receiving hemodialysis support in our clinic were included. The median age was 67 years old (min: 35; max: 91 years), and all of our patients had primary hypertension and other comorbidities. Their clinical evaluation showed that dry cough (47.8%) and shortness of breath (47.8%) were the most common symptoms. Fever was less pronounced (30.4%). The median time from the onset of symptoms to hospitalization was 1 day (min: 0; max:), and the time from hospitalization to death was 18 days (min: 1; max: 22). Transfer from the inpatient ward to the ICU took a median of 7 days (min: 1; max: 13). Among the 23 patients, 3 died during follow-up, and 20 were discharged with full recovery. Baseline ferritin, procalcitonin levels, and CRP/albumin rates were higher, and neutrophil/lymphocyte levels were lower in patients who eventually died. In these patients, despite being nonsignificant, there were more diabetic patients, and the D-dimer levels were higher than 1000 ugFEU/L. Conclusion: The COVID-19 infection is associated with increased mortality in chronic kidney diseases patients. Despite being nonsignificant, there was a trend towards increased mortality in patient with diabetes, D-dimer levels >1000 ugFEU/L, higher ferritin and prokalsitonin levels, an increased CRP/albumin ratio, and a lower neutrophil/lymphocyte ratio. This work is licensed under a Creative Commons Attribution 4.0 International License.
Background/aim: The COVID-19infection, which started in Wuhan City, China, in December 2019, turned into a pandemic in a very short time, affecting mainly the elderly and those with serious chronic illnesses. COVID-19infections have been observed to have a high mortality rate, especially in patients undergoing maintenance hemodialysis. Materials and methods: Forty-two patients over 18 years of age who underwent a maintenance hemodialysis program at our unit, who tested positive for COVID-19 by PCR from nasopharyngeal swabs, and/or who were observed to have disease-related signs in their CTs were included in the study. Results: In this study, 23 of 42 patients receiving hemodialysis support in our clinic were included. The median age was 67 years old (min: 35; max: 91 years), and all of our patients had primary hypertension and other comorbidities. Their clinical evaluation showed that dry cough (47.8%) and shortness of breath (47.8%) were the most common symptoms. Fever was less pronounced (30.4%). The median time from the onset of symptoms to hospitalization was 1 day (min: 0; max:), and the time from hospitalization to death was 18 days (min: 1; max: 22). Transfer from the inpatient ward to the ICU took a median of 7 days (min: 1; max: 13). Among the 23 patients, 3 died during follow-up, and 20 were discharged with full recovery. Baseline ferritin, procalcitonin levels, and CRP/albumin rates were higher, and neutrophil/lymphocyte levels were lower in patients who eventually died. In these patients, despite being nonsignificant, there were more diabeticpatients, and the D-dimer levels were higher than 1000 ugFEU/L. Conclusion: The COVID-19infection is associated with increased mortality in chronic kidney diseasespatients. Despite being nonsignificant, there was a trend towards increased mortality in patient with diabetes, D-dimer levels >1000 ugFEU/L, higher ferritin and prokalsitonin levels, an increased CRP/albumin ratio, and a lower neutrophil/lymphocyte ratio. This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors: Allan J Collins; Robert N Foley; Charles Herzog; Blanche M Chavers; David Gilbertson; Areef Ishani; Bertram L Kasiske; Jiannong Liu; Lih-Wen Mau; Marshall McBean; Anne Murray; Wendy St Peter; Haifeng Guo; Qi Li; Shuling Li; Suying Li; Yi Peng; Yang Qiu; Tricia Roberts; Melissa Skeans; Jon Snyder; Craig Solid; Changchun Wang; Eric Weinhandl; David Zaun; Cheryl Arko; Shu-Cheng Chen; Frederick Dalleska; Frank Daniels; Stephan Dunning; James Ebben; Eric Frazier; Christopher Hanzlik; Roger Johnson; Daniel Sheets; Xinyue Wang; Beth Forrest; Edward Constantini; Susan Everson; Paul W Eggers; Lawrence Agodoa Journal: Am J Kidney Dis Date: 2010-01 Impact factor: 8.860
Authors: Tarek Abdel Latif Ghonimi; Mohamad Mahmood Alkad; Essa Abdulla Abuhelaiqa; Muftah M Othman; Musab Ahmed Elgaali; Rania Abdelaziz M Ibrahim; Shajahan M Joseph; Hassan Ali Al-Malki; Abdullah Ibrahim Hamad Journal: PLoS One Date: 2021-07-22 Impact factor: 3.240