Literature DB >> 32949595

What if there's no such thing as "aging"?

Alan A Cohen1, Véronique Legault2, Tamàs Fülöp3.   

Abstract

Are diseases caused by aging? What are the mechanisms of aging? Do all species age? These hotly debated questions revolve around a unitary definition of aging. Because we use the word "aging" so frequently, both colloquially and scientifically, we rarely pause to consider whether this word maps to an underlying biological phenomenon, or whether it is simply a grab-bag of diverse phenomena linked more by our mental associations than by any underlying biology. Here, we consider how the presence of the colloquial word "aging" generates a cognitive bias towards supposing there is a unitary biological phenomenon. We ask what kind of evidence would support or refute that idea, and subsequently show clear evidence at multiple levels that aging is not a unitary phenomenon. In particular, the known aging pathways lead to heterogeneous outputs, not a single coordinated phenomenon. From levels ranging from cellular/molecular to clinical to demographic to evolutionary, we show how the supposition that aging is a unitary phenomenon can mislead and distract us from asking the best questions. For major sub-disciplines of aging biology, we show how going beyond the notion of unitary aging can hone the paradigm and help advance the pace of discovery.
Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.

Keywords:  Bow-tie; Complex systems; Information theory; Linguistics; Neural network; Paradigm; Philosophy of science; Sapir-Whorf

Year:  2020        PMID: 32949595     DOI: 10.1016/j.mad.2020.111344

Source DB:  PubMed          Journal:  Mech Ageing Dev        ISSN: 0047-6374            Impact factor:   5.432


  5 in total

1.  Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework.

Authors:  Alan A Cohen; Brian K Kennedy; Ulrich Anglas; Anne M Bronikowski; Joris Deelen; Frédérik Dufour; Gerardo Ferbeyre; Luigi Ferrucci; Claudio Franceschi; Daniela Frasca; Bertrand Friguet; Pierrette Gaudreau; Vadim N Gladyshev; Efstathios S Gonos; Vera Gorbunova; Philipp Gut; Mikhail Ivanchenko; Véronique Legault; Jean-François Lemaître; Thomas Liontis; Guang-Hui Liu; Mingxin Liu; Andrea B Maier; Otávio T Nóbrega; Marcel G M Olde Rikkert; Graham Pawelec; Sylvie Rheault; Alistair M Senior; Andreas Simm; Sonja Soo; Annika Traa; Svetlana Ukraintseva; Quentin Vanhaelen; Jeremy M Van Raamsdonk; Jacek M Witkowski; Anatoliy I Yashin; Robert Ziman; Tamàs Fülöp
Journal:  Mech Ageing Dev       Date:  2020-07-18       Impact factor: 5.432

Review 2.  Robust Physiological Metrics From Sparsely Sampled Networks.

Authors:  Alan A Cohen; Sebastien Leblanc; Xavier Roucou
Journal:  Front Physiol       Date:  2021-02-10       Impact factor: 4.566

3.  Association of Pace of Aging Measured by Blood-Based DNA Methylation With Age-Related Cognitive Impairment and Dementia.

Authors:  Karen Sugden; Avshalom Caspi; Maxwell L Elliott; Kyle J Bourassa; Kartik Chamarti; David L Corcoran; Ahmad R Hariri; Renate M Houts; Meeraj Kothari; Stephen Kritchevsky; George A Kuchel; Jonathan S Mill; Benjamin S Williams; Daniel W Belsky; Terrie E Moffitt
Journal:  Neurology       Date:  2022-07-06       Impact factor: 11.800

4.  An essay on the nominal vs. real definitions of aging.

Authors:  Aleksei G Golubev
Journal:  Biogerontology       Date:  2021-06-06       Impact factor: 4.277

Review 5.  The Danaid Theory of Aging.

Authors:  Maarten J Wensink; Alan A Cohen
Journal:  Front Cell Dev Biol       Date:  2022-01-03
  5 in total

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