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Literature DB >> 32949467

White matter lesions in multiple sclerosis are enriched for CD20^dim CD8⁺ tissue-resident memory T cells.

Cheng-Chih Hsiao^1,2, Nina L Fransen¹, Aletta M R van den Bosch¹, Kim I M Brandwijk³, Inge Huitinga^1,4, Jörg Hamann^1,2, Joost Smolders^1,5.

Abstract

Brain CD8+ CD69+ tissue-resident memory T (TRM ) cells comprise a CD20dim subset, which is proportionally larger in CD103-negative TRM cells. In multiple sclerosis (MS) lesions, CD20dim TRM -cell proportions are increased. CD20-expression is associated with higher levels of CXCR6, Ki-67, and granzyme B, supporting CD20dim TRM cells as a relevant subset in MS.

Entities: Disease Gene

Keywords: CD20; brain; human; multiple sclerosis; tissue-resident memory T cells

Mesh：

Substances：

Year: 2020 PMID： 32949467 DOI： 10.1002/eji.202048665

Source DB: PubMed Journal: Eur J Immunol ISSN： 0014-2980 Impact factor: 5.532

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Cited

5 in total

Review 1. T-cell surveillance of the human brain in health and multiple sclerosis.

Authors: Joost Smolders; Marvin M van Luijn; Cheng-Chih Hsiao; Jörg Hamann
Journal: Semin Immunopathol Date: 2022-04-01 Impact factor: 9.623

Review 2. CD20⁺ T cells: an emerging T cell subset in human pathology.

Authors: Adrian Y S Lee
Journal: Inflamm Res Date: 2022-08-11 Impact factor: 6.986

3. Ofatumumab Modulates Inflammatory T Cell Responses and Migratory Potential in Patients With Multiple Sclerosis.

Authors: Marina Rode von Essen; Rikke Holm Hansen; Camilla Højgaard; Cecilie Ammitzbøll; Heinz Wiendl; Finn Sellebjerg
Journal: Neurol Neuroimmunol Neuroinflamm Date: 2022-06-07

4. Distinct Effector Programs of Brain-Homing CD8⁺ T Cells in Multiple Sclerosis.

Authors: Steven C Koetzier; Jamie van Langelaar; Marie-José Melief; Annet F Wierenga-Wolf; Cato E A Corsten; Katelijn M Blok; Cindy Hoeks; Bieke Broux; Beatrijs Wokke; Marvin M van Luijn; Joost Smolders
Journal: Cells Date: 2022-05-13 Impact factor: 7.666

Review 5. PD-1/PD-L Axis in Neuroinflammation: New Insights.

Authors: Susanna Manenti; Mario Orrico; Stefano Masciocchi; Alessandra Mandelli; Annamaria Finardi; Roberto Furlan
Journal: Front Neurol Date: 2022-06-09 Impact factor: 4.086