Ozlem Onerci Celebi1,2, Sungjin A Song2,3, Alena Santeerapharp4, Kanittha Choksawad5, Ramon A Franco6,7,8. 1. Istanbul Training and Research Hospital, Otolaryngology Head and Neck Surgery Clinic, Istanbul, Turkey. 2. Department of Otolaryngology, Massachusetts Eye and Ear, Boston, MA, USA. 3. Department of Otolaryngology, Harvard Medica School, Boston, MA, USA. 4. Department of Otorhinolaryngology, Faculty of Medicine, Srinakharinwirot University, Bangkok, Thailand. 5. Department of Otolaryngology, Panyananthapikkhu Chonprathan Medical Center Srinakharinwirot University, Bangkok, Thailand. 6. Department of Otolaryngology, Massachusetts Eye and Ear, Boston, MA, USA. Ramon_Franco@meei.harvard.edu. 7. Department of Otolaryngology, Harvard Medica School, Boston, MA, USA. Ramon_Franco@meei.harvard.edu. 8. Division of Laryngology, Department of Otolaryngology, Voice and Speech Laboratory, Mass Eye and Ear, Harvard Medical School, 243 Charles Street, Boston, MA, 02114, USA. Ramon_Franco@meei.harvard.edu.
Abstract
PURPOSE: To assess the incidence and severity of 12 systemic side effects of serial intralesional steroid injections (SILSI) in patients with idiopathic subglottic stenosis (iSGS). METHODS: This retrospective study included patients with iSGS who underwent SILSI with Triamcinolone 40 mg/dL. After SILSI, the patients were asked to answer 12 questions regarding frequently encountered systemic side effects of steroids. Each answer was rated as mild, moderate, or severe. Descriptive statistics were used to analyze and present the findings. RESULTS: The study included 49 patients (42 female and 7 male) with a mean age of 59.1 years (range 21-83 years). Post-SILSI treatment, 27 (55%) reported experiencing side effects while 22 (45%) patients reported no side effects. The most frequent side effect reported in women of reproductive age (n: 8) was menstrual irregularities (3/8, 37%). Other frequently reported side effects were feeling joyful and sleeping difficulties, each reported by 30% of the patients. All side effects resolved after the completion of SILSI. CONCLUSIONS: SILSI can be administered with minimal tolerable side effects. Clinicians should make their patients aware of the most frequent side effects. Special attention should be given to women of reproductive age to inform them of the possibility of menstrual irregularities during SILSI.
PURPOSE: To assess the incidence and severity of 12 systemic side effects of serial intralesional steroid injections (SILSI) in patients with idiopathic subglottic stenosis (iSGS). METHODS: This retrospective study included patients with iSGS who underwent SILSI with Triamcinolone 40 mg/dL. After SILSI, the patients were asked to answer 12 questions regarding frequently encountered systemic side effects of steroids. Each answer was rated as mild, moderate, or severe. Descriptive statistics were used to analyze and present the findings. RESULTS: The study included 49 patients (42 female and 7 male) with a mean age of 59.1 years (range 21-83 years). Post-SILSI treatment, 27 (55%) reported experiencing side effects while 22 (45%) patients reported no side effects. The most frequent side effect reported in women of reproductive age (n: 8) was menstrual irregularities (3/8, 37%). Other frequently reported side effects were feeling joyful and sleeping difficulties, each reported by 30% of the patients. All side effects resolved after the completion of SILSI. CONCLUSIONS: SILSI can be administered with minimal tolerable side effects. Clinicians should make their patients aware of the most frequent side effects. Special attention should be given to women of reproductive age to inform them of the possibility of menstrual irregularities during SILSI.
Entities:
Keywords:
Intralesional steroid injection; Local steroid treatment; Steroid side effects; Subglottic stenosis
Authors: Robert J Morrison; Nicolas-George Katsantonis; Kevin M Motz; Alexander T Hillel; C Gaelyn Garrett; James L Netterville; Christopher T Wootten; Susan M Majka; Timothy S Blackwell; Wonder P Drake; Alexander Gelbard Journal: Otolaryngol Head Neck Surg Date: 2018-10-16 Impact factor: 3.497