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Literature DB >> 32948447

Advances in Inflammasome Research: Recent Breakthroughs and Future Hurdles.

Rebecca E Tweedell¹, Thirumala-Devi Kanneganti².

Abstract

Inflammasomes are a group of cytosolic multiprotein complexes that are assembled in response to pathogen- and damage-associated molecular patterns and cellular stress. Inflammasome assembly drives the maturation and secretion of proinflammatory cytokines and induces pyroptosis. Here, we highlight key advances in inflammasome research with therapeutic potential.

Keywords: AIM2; NLRC4; NLRP1; NLRP3; PANoptosis; PANoptosome; Pyrin; apoptosis; gasdermin; inflammasome; inflammatory cell death; necroptosis; pyroptosis

Year: 2020 PMID： 32948447 PMCID： PMC7678016 DOI： 10.1016/j.molmed.2020.07.010

Source DB: PubMed Journal: Trends Mol Med ISSN： 1471-4914 Impact factor: 11.951

12 in total

Review 1. Diverging inflammasome signals in tumorigenesis and potential targeting.

Authors: Rajendra Karki; Thirumala-Devi Kanneganti
Journal: Nat Rev Cancer Date: 2019-04 Impact factor: 60.716

2. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death.

Authors: Jianjin Shi; Yue Zhao; Kun Wang; Xuyan Shi; Yue Wang; Huanwei Huang; Yinghua Zhuang; Tao Cai; Fengchao Wang; Feng Shao
Journal: Nature Date: 2015-09-16 Impact factor: 49.962

3. Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling.

Authors: Nobuhiko Kayagaki; Irma B Stowe; Bettina L Lee; Karen O'Rourke; Keith Anderson; Søren Warming; Trinna Cuellar; Benjamin Haley; Merone Roose-Girma; Qui T Phung; Peter S Liu; Jennie R Lill; Hong Li; Jiansheng Wu; Sarah Kummerfeld; Juan Zhang; Wyne P Lee; Scott J Snipas; Guy S Salvesen; Lucy X Morris; Linda Fitzgerald; Yafei Zhang; Edward M Bertram; Christopher C Goodnow; Vishva M Dixit
Journal: Nature Date: 2015-09-16 Impact factor: 49.962

4. Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense.

Authors: Min Zheng; Rajendra Karki; Peter Vogel; Thirumala-Devi Kanneganti
Journal: Cell Date: 2020-04-15 Impact factor: 41.582

5. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta.

Authors: Fabio Martinon; Kimberly Burns; Jürg Tschopp
Journal: Mol Cell Date: 2002-08 Impact factor: 17.970

6. Glyburide inhibits the Cryopyrin/Nalp3 inflammasome.

Authors: Mohamed Lamkanfi; James L Mueller; Alberto C Vitari; Shahram Misaghi; Anna Fedorova; Kurt Deshayes; Wyne P Lee; Hal M Hoffman; Vishva M Dixit
Journal: J Cell Biol Date: 2009-10-05 Impact factor: 10.539

7. A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.

Authors: Rebecca C Coll; Avril A B Robertson; Jae Jin Chae; Sarah C Higgins; Raúl Muñoz-Planillo; Marco C Inserra; Irina Vetter; Lara S Dungan; Brian G Monks; Andrea Stutz; Daniel E Croker; Mark S Butler; Moritz Haneklaus; Caroline E Sutton; Gabriel Núñez; Eicke Latz; Daniel L Kastner; Kingston H G Mills; Seth L Masters; Kate Schroder; Matthew A Cooper; Luke A J O'Neill
Journal: Nat Med Date: 2015-02-16 Impact factor: 53.440

8. OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation.

Authors: Carlo Marchetti; Benjamin Swartzwelter; Fabia Gamboni; Charles P Neff; Katrin Richter; Tania Azam; Sonia Carta; Isak Tengesdal; Travis Nemkov; Angelo D'Alessandro; Curtis Henry; Gerald S Jones; Scott A Goodrich; Joseph P St Laurent; Terry M Jones; Curtis L Scribner; Robert B Barrow; Roy D Altman; Damaris B Skouras; Marco Gattorno; Veronika Grau; Sabina Janciauskiene; Anna Rubartelli; Leo A B Joosten; Charles A Dinarello
Journal: Proc Natl Acad Sci U S A Date: 2018-01-29 Impact factor: 11.205

9. Innate immune priming in the absence of TAK1 drives RIPK1 kinase activity-independent pyroptosis, apoptosis, necroptosis, and inflammatory disease.

Authors: R K Subbarao Malireddi; Prajwal Gurung; Sannula Kesavardhana; Parimal Samir; Amanda Burton; Harisankeerth Mummareddy; Peter Vogel; Stephane Pelletier; Sandeepta Burgula; Thirumala-Devi Kanneganti
Journal: J Exp Med Date: 2020-03-02 Impact factor: 14.307

10. Identification of the PANoptosome: A Molecular Platform Triggering Pyroptosis, Apoptosis, and Necroptosis (PANoptosis).

Authors: Shelbi Christgen; Min Zheng; Sannula Kesavardhana; Rajendra Karki; R K Subbarao Malireddi; Balaji Banoth; David E Place; Benoit Briard; Bhesh Raj Sharma; Shraddha Tuladhar; Parimal Samir; Amanda Burton; Thirumala-Devi Kanneganti
Journal: Front Cell Infect Microbiol Date: 2020-05-29 Impact factor: 5.293

3 in total

Review 1. The Signaling Pathways Regulating NLRP3 Inflammasome Activation.

Authors: Ming-Ye Chen; Xun-Jia Ye; Xian-Hui He; Dong-Yun Ouyang
Journal: Inflammation Date: 2021-05-19 Impact factor: 4.092

Review 2. Extracellular Adenosine Triphosphate (eATP) and Its Metabolite, Extracellular Adenosine (eAdo), as Opposing "Yin-Yang" Regulators of Nlrp3 Inflammasome in the Trafficking of Hematopoietic Stem/Progenitor Cells.

Authors: Mariusz Z Ratajczak; Magda Kucia
Journal: Front Immunol Date: 2021-01-29 Impact factor: 7.561

3. Design, synthesis and biological evaluation of 1,5-disubstituted α-amino tetrazole derivatives as non-covalent inflammasome-caspase-1 complex inhibitors with potential application against immune and inflammatory disorders.

Authors: Fausta Ulgheri; Pietro Spanu; Francesco Deligia; Giovanni Loriga; Maria Pia Fuggetta; Iris de Haan; Ajay Chandgudge; Matthew Groves; Alexander Domling
Journal: Eur J Med Chem Date: 2021-11-18 Impact factor: 6.514

3 in total