Literature DB >> 32948337

Evidence-based surgical hypothesis: Partial heart transplantation can deliver growing valve implants for congenital cardiac surgery.

Taufiek Konrad Rajab1.   

Abstract

Children undergoing congenital cardiac surgery often outgrow the valve implants. These children are thus committed to morbid reoperations for successive exchanges of the vavular implants that they have outgrown. Therefore the holy grail of congenital cardiac surgery is a valve implant that grows with the recipient child. Preserved homografts routinely are used as valve implants, but they do not grow as the child grows because they lose viability during preservation. In contrast, pulmonary autografts and pediatric heart transplants grow with the recipient children. Similarly, partial heart transplantation can deliver growing valve implants for congenital cardiac surgery. Temporary immune suppression would only be needed until the partial heart transplant can be exchanged for an adult-sized prosthetic valve in the grown child.
Copyright © 2020 Elsevier Inc. All rights reserved.

Entities:  

Year:  2020        PMID: 32948337     DOI: 10.1016/j.surg.2020.07.051

Source DB:  PubMed          Journal:  Surgery        ISSN: 0039-6060            Impact factor:   3.982


  2 in total

Review 1.  Immune Privilege of Heart Valves.

Authors:  Morgan Ashley Hill; Jennie H Kwon; Brielle Gerry; William A Hardy; Olivia Agata Walkowiak; Minoo N Kavarana; Satish N Nadig; T Konrad Rajab
Journal:  Front Immunol       Date:  2021-08-10       Impact factor: 7.561

Review 2.  Cellular Viability of Partial Heart Transplant Grafts in Cold Storage.

Authors:  Jennie H Kwon; Morgan Ashley Hill; Brielle Gerry; Jordan Morningstar; Minoo N Kavarana; Satish N Nadig; Taufiek Konrad Rajab
Journal:  Front Surg       Date:  2021-07-13
  2 in total

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