Megan E Renna1, M Rosie Shrout2, Annelise A Madison3, Catherine M Alfano4, Stephen P Povoski5, Adele M Lipari5, Doreen M Agnese5, William E Carson5, Janice K Kiecolt-Glaser6. 1. Institute for Behavioral Medicine Research, The Ohio State University College of Medicine, Columbus, OH, USA; Comprehensive Cancer Center, The Ohio State University College of Medicine, Columbus, OH, USA. Electronic address: Megan.Renna@osumc.edu. 2. Institute for Behavioral Medicine Research, The Ohio State University College of Medicine, Columbus, OH, USA. 3. Institute for Behavioral Medicine Research, The Ohio State University College of Medicine, Columbus, OH, USA; Department of Psychology, The Ohio State University, Columbus, OH, USA. 4. American Cancer Society, Inc. Atlanta, GA, USA. 5. Comprehensive Cancer Center, The Ohio State University College of Medicine, Columbus, OH, USA; Department of Surgery, The Ohio State University College of Medicine, Columbus, OH, USA. 6. Institute for Behavioral Medicine Research, The Ohio State University College of Medicine, Columbus, OH, USA; Department of Psychiatry and Behavioral Health, The Ohio State University College of Medicine, Columbus, OH, USA.
Abstract
BACKGROUND: Among breast cancer survivors, elevated inflammation has been linked to greater recurrence risk. Psychological processes, such as cancer-related distress, can pose threats to a survivor's longevity and wellbeing. Although distress can heighten inflammation, little is known about how fluctuations in distress during and after treatment impact a woman's own inflammation - the primary question of this study. METHODS: Breast cancer survivors (n = 165, stages 0-III) completed a baseline visit before treatment and two follow-up visits 6 and 18 months after. At each visit, women completed the Impact of Events Scale to assess cancer-related distress, and a blood sample was collected to measure proinflammatory cytokines IL-6, TNF-α, IL-1β, and IL-8. This longitudinal study related fluctuations in survivor's own cancer-related distress (i.e., within-person effects), as well as average effects of cancer-related distress between survivors (i.e., between-person effects) to inflammatory changes across visits. RESULTS: Women had elevated inflammation at visits where they expressed more cancer-related distress than what was typical. In contrast, the average cancer-related distress was not associated with inflammation. CONCLUSION: Larger increases in a women's cancer-related distress was linked with higher inflammation across visits. Comparing a survivor's own cancer-related distress to her average levels may prove useful in identifying links between distress and inflammation.
BACKGROUND: Among breast cancer survivors, elevated inflammation has been linked to greater recurrence risk. Psychological processes, such as cancer-related distress, can pose threats to a survivor's longevity and wellbeing. Although distress can heighten inflammation, little is known about how fluctuations in distress during and after treatment impact a woman's own inflammation - the primary question of this study. METHODS:Breast cancer survivors (n = 165, stages 0-III) completed a baseline visit before treatment and two follow-up visits 6 and 18 months after. At each visit, women completed the Impact of Events Scale to assess cancer-related distress, and a blood sample was collected to measure proinflammatory cytokines IL-6, TNF-α, IL-1β, and IL-8. This longitudinal study related fluctuations in survivor's own cancer-related distress (i.e., within-person effects), as well as average effects of cancer-related distress between survivors (i.e., between-person effects) to inflammatory changes across visits. RESULTS:Women had elevated inflammation at visits where they expressed more cancer-related distress than what was typical. In contrast, the average cancer-related distress was not associated with inflammation. CONCLUSION: Larger increases in a women's cancer-related distress was linked with higher inflammation across visits. Comparing a survivor's own cancer-related distress to her average levels may prove useful in identifying links between distress and inflammation.
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Authors: Megan E Renna; M Rosie Shrout; Annelise A Madison; Maryam Lustberg; Stephen P Povoski; Doreen M Agnese; Raquel E Reinbolt; Robert Wesolowski; Nicole O Williams; Bhuvaneswari Ramaswamy; Sagar D Sardesai; Anne M Noonan; Jeffrey B VanDeusen; Daniel G Stover; Mathew Cherian; William B Malarkey; Michael Di Gregorio; Janice K Kiecolt-Glaser Journal: Int J Behav Med Date: 2022-07-13
Authors: Annelise A Madison; Juan Peng; M Rosie Shrout; Megan E Renna; Catherine M Alfano; Stephen P Povoski; Adele M Lipari; Doreen M Agnese; William E Carson; William B Malarkey; Janice K Kiecolt-Glaser Journal: Psychoneuroendocrinology Date: 2021-05-27 Impact factor: 4.693