Literature DB >> 32946778

A Metabolic Bottleneck for Stem Cell Transformation.

Sanjeethan C Baksh1, Elaine Fuchs2.   

Abstract

Although oncogenic mutations predispose tissue stem cells to tumor initiation, the rate-limiting processes for stem cell immortalization remain unknown. In this issue of Cell, Bonnay et al. identify enhanced electron transport chain activity as a critical determinant of this process, establishing metabolic reprogramming as limiting for tumor initiation.
Copyright © 2020 Elsevier Inc. All rights reserved.

Entities:  

Year:  2020        PMID： 32946778      PMCID： PMC7861329          DOI： 10.1016/j.cell.2020.08.038

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  10 in total

1.  Ecdysone and mediator change energy metabolism to terminate proliferation in Drosophila neural stem cells.

Authors:  Catarina C F Homem; Victoria Steinmann; Thomas R Burkard; Alexander Jais; Harald Esterbauer; Juergen A Knoblich
Journal:  Cell       Date:  2014-08-14       Impact factor: 41.582

Review 2.  Mitochondrial Dynamics in Regulating the Unique Phenotypes of Cancer and Stem Cells.

Authors:  Hsiuchen Chen; David C Chan
Journal:  Cell Metab       Date:  2017-06-22       Impact factor: 27.287

3.  Oxidative Metabolism Drives Immortalization of Neural Stem Cells during Tumorigenesis.

Authors:  François Bonnay; Ana Veloso; Victoria Steinmann; Thomas Köcher; Merve Deniz Abdusselamoglu; Sunanjay Bajaj; Elisa Rivelles; Lisa Landskron; Harald Esterbauer; Robert P Zinzen; Juergen A Knoblich
Journal:  Cell       Date:  2020-09-10       Impact factor: 41.582

Review 4.  Repositioning metformin for cancer prevention and treatment.

Authors:  Brendan J Quinn; Hiroshi Kitagawa; Regan M Memmott; Joell J Gills; Phillip A Dennis
Journal:  Trends Endocrinol Metab       Date:  2013-06-15       Impact factor: 12.015

5.  Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells.

Authors:  Lucas B Sullivan; Dan Y Gui; Aaron M Hosios; Lauren N Bush; Elizaveta Freinkman; Matthew G Vander Heiden
Journal:  Cell       Date:  2015-07-30       Impact factor: 41.582

6.  An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis.

Authors:  Kıvanç Birsoy; Tim Wang; Walter W Chen; Elizaveta Freinkman; Monther Abu-Remaileh; David M Sabatini
Journal:  Cell       Date:  2015-07-30       Impact factor: 41.582

Review 7.  Refining the role for adult stem cells as cancer cells of origin.

Authors:  Andrew C White; William E Lowry
Journal:  Trends Cell Biol       Date:  2014-09-18       Impact factor: 20.808

Review 8.  Metabolic signatures of cancer cells and stem cells.

Authors:  Andrew M Intlekofer; Lydia W S Finley
Journal:  Nat Metab       Date:  2019-02-11

9.  Tissue-specific mutation accumulation in human adult stem cells during life.

Authors:  Francis Blokzijl; Joep de Ligt; Myrthe Jager; Valentina Sasselli; Sophie Roerink; Nobuo Sasaki; Meritxell Huch; Sander Boymans; Ewart Kuijk; Pjotr Prins; Isaac J Nijman; Inigo Martincorena; Michal Mokry; Caroline L Wiegerinck; Sabine Middendorp; Toshiro Sato; Gerald Schwank; Edward E S Nieuwenhuis; Monique M A Verstegen; Luc J W van der Laan; Jeroen de Jonge; Jan N M IJzermans; Robert G Vries; Marc van de Wetering; Michael R Stratton; Hans Clevers; Edwin Cuppen; Ruben van Boxtel
Journal:  Nature       Date:  2016-10-03       Impact factor: 49.962

10.  Extracellular serine controls epidermal stem cell fate and tumour initiation.

Authors:  Sanjeethan C Baksh; Pavlina K Todorova; Shiri Gur-Cohen; Brian Hurwitz; Yejing Ge; Jesse S S Novak; Matthew T Tierney; June Dela Cruz-Racelis; Elaine Fuchs; Lydia W S Finley
Journal:  Nat Cell Biol       Date:  2020-05-25       Impact factor: 28.213
  10 in total

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