| Literature DB >> 32946775 |
Rui Dong1, Ran Yang2, Yong Zhan2, Hua-Dong Lai3, Chun-Jing Ye2, Xiao-Ying Yao4, Wen-Qin Luo5, Xiao-Mu Cheng3, Ju-Ju Miao3, Jun-Feng Wang2, Bai-Hui Liu2, Xiang-Qi Liu2, Lu-Lu Xie2, Yi Li2, Man Zhang3, Lian Chen6, Wei-Chen Song7, Wei Qian3, Wei-Qiang Gao8, Yun-Hui Tang4, Chun-Yan Shen4, Wei Jiang9, Gong Chen2, Wei Yao2, Kui-Ran Dong2, Xian-Min Xiao2, Shan Zheng2, Kai Li10, Jia Wang11.
Abstract
Neuroblastoma (NB), which is a subtype of neural-crest-derived malignancy, is the most common extracranial solid tumor occurring in childhood. Despite extensive research, the underlying developmental origin of NB remains unclear. Using single-cell RNA sequencing, we generate transcriptomes of adrenal NB from 160,910 cells of 16 patients and transcriptomes of putative developmental cells of origin of NB from 12,103 cells of early human embryos and fetal adrenal glands at relatively late development stages. We find that most adrenal NB tumor cells transcriptionally mirror noradrenergic chromaffin cells. Malignant states also recapitulate the proliferation/differentiation status of chromaffin cells in the process of normal development. Our findings provide insight into developmental trajectories and cellular states underlying human initiation and progression of NB.Entities:
Keywords: Schwann cell precursors; cell differentiation; cell proliferation; cells of origin; chromaffin cells; neural crest cells; neuroblastoma; pediatric cancer; single-cell RNA sequencing; tumor heterogeneity
Mesh：
Year: 2020 PMID： 32946775 DOI： 10.1016/j.ccell.2020.08.014
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743