Literature DB >> 32946774

Cancer Screening, Surrogates of Survival, and the Soma.

James DeGregori1, Paul Pharoah2, Peter Sasieni3, Charles Swanton4.   

Abstract

Screening leads to meaningful reductions in deaths from cancers. However, reductions in all-cause mortality (ACM) are harder to demonstrate. Failure to demonstrate ACM benefit should not diminish advances in cancer screening. We consider how co-morbidities related to an aging and damaged soma can hinder achievement of ACM benefit. Crown
Copyright © 2020. Published by Elsevier Inc. All rights reserved.

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Year:  2020        PMID: 32946774     DOI: 10.1016/j.ccell.2020.09.003

Source DB:  PubMed          Journal:  Cancer Cell        ISSN: 1535-6108            Impact factor:   31.743


  4 in total

Review 1.  Cancer evolution: Darwin and beyond.

Authors:  Roberto Vendramin; Kevin Litchfield; Charles Swanton
Journal:  EMBO J       Date:  2021-08-30       Impact factor: 14.012

Review 2.  The sculpting of somatic mutational landscapes by evolutionary forces and their impacts on aging-related disease.

Authors:  Fabio Marongiu; James DeGregori
Journal:  Mol Oncol       Date:  2022-06-29       Impact factor: 7.449

3.  Cell-Free DNA-Based Multi-Cancer Early Detection Test in an Asymptomatic Screening Population (NHS-Galleri): Design of a Pragmatic, Prospective Randomised Controlled Trial.

Authors:  Richard D Neal; Peter Johnson; Christina A Clarke; Stephanie A Hamilton; Nan Zhang; Harpal Kumar; Charles Swanton; Peter Sasieni
Journal:  Cancers (Basel)       Date:  2022-10-01       Impact factor: 6.575

4.  Cancer and aging: A call to action.

Authors:  Dejana Braithwaite; Stephen Anton; Supriya Mohile; James DeGregori; Nancy Gillis; Daohong Zhou; Shirley Bloodworth; Marco Pahor; Jonathan Licht
Journal:  Aging Cancer       Date:  2022-07-12
  4 in total

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