Literature DB >> 32946755

Winding Down: Selectively Drugging a Promiscuous Pocket in Cryptochrome Slows Circadian Rhythms.

Brian R Crane1.   

Abstract

Mammalian cryptochromes regulate sleep and metabolism as components of the circadian clock. In this issue of Cell Chemical Biology, Miller et al. (2020a) use phenotypic chemical screens to identify selective modulators of two cryptochrome isoforms. Binding specificity depends on conformational patterning of the ligand-binding pocket and a disordered C-terminal domain.
Copyright © 2020 Elsevier Ltd. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2020        PMID： 32946755      PMCID： PMC8042606          DOI： 10.1016/j.chembiol.2020.08.002

Source DB:  PubMed          Journal:  Cell Chem Biol        ISSN： 2451-9448            Impact factor:   8.116


  10 in total

Review 1.  The cryptochromes: blue light photoreceptors in plants and animals.

Authors:  Inês Chaves; Richard Pokorny; Martin Byrdin; Nathalie Hoang; Thorsten Ritz; Klaus Brettel; Lars-Oliver Essen; Gijsbertus T J van der Horst; Alfred Batschauer; Margaret Ahmad
Journal:  Annu Rev Plant Biol       Date:  2011       Impact factor: 26.379

2.  An Isoform-Selective Modulator of Cryptochrome 1 Regulates Circadian Rhythms in Mammals.

Authors:  Simon Miller; Yoshiki Aikawa; Akiko Sugiyama; Yoshiko Nagai; Aya Hara; Tsuyoshi Oshima; Kazuma Amaike; Steve A Kay; Kenichiro Itami; Tsuyoshi Hirota
Journal:  Cell Chem Biol       Date:  2020-06-04       Impact factor: 8.116

3.  Mutation of the Human Circadian Clock Gene CRY1 in Familial Delayed Sleep Phase Disorder.

Authors:  Alina Patke; Patricia J Murphy; Onur Emre Onat; Ana C Krieger; Tayfun Özçelik; Scott S Campbell; Michael W Young
Journal:  Cell       Date:  2017-04-06       Impact factor: 41.582

4.  Identification of small molecule activators of cryptochrome.

Authors:  Tsuyoshi Hirota; Jae Wook Lee; Peter C St John; Mariko Sawa; Keiko Iwaisako; Takako Noguchi; Pagkapol Y Pongsawakul; Tim Sonntag; David K Welsh; David A Brenner; Francis J Doyle; Peter G Schultz; Steve A Kay
Journal:  Science       Date:  2012-07-12       Impact factor: 47.728

5.  Isoform-selective regulation of mammalian cryptochromes.

Authors:  Simon Miller; You Lee Son; Yoshiki Aikawa; Eri Makino; Yoshiko Nagai; Ashutosh Srivastava; Tsuyoshi Oshima; Akiko Sugiyama; Aya Hara; Kazuhiro Abe; Kunio Hirata; Shinya Oishi; Shinya Hagihara; Ayato Sato; Florence Tama; Kenichiro Itami; Steve A Kay; Megumi Hatori; Tsuyoshi Hirota
Journal:  Nat Chem Biol       Date:  2020-03-30       Impact factor: 15.040

Review 6.  Transcriptional architecture of the mammalian circadian clock.

Authors:  Joseph S Takahashi
Journal:  Nat Rev Genet       Date:  2016-12-19       Impact factor: 53.242

7.  Dynamics at the serine loop underlie differential affinity of cryptochromes for CLOCK:BMAL1 to control circadian timing.

Authors:  Jennifer L Fribourgh; Ashutosh Srivastava; Colby R Sandate; Alicia K Michael; Peter L Hsu; Christin Rakers; Leslee T Nguyen; Megan R Torgrimson; Gian Carlo G Parico; Sarvind Tripathi; Ning Zheng; Gabriel C Lander; Tsuyoshi Hirota; Florence Tama; Carrie L Partch
Journal:  Elife       Date:  2020-02-26       Impact factor: 8.140

8.  SCF(FBXL3) ubiquitin ligase targets cryptochromes at their cofactor pocket.

Authors:  Weiman Xing; Luca Busino; Thomas R Hinds; Samuel T Marionni; Nabiha H Saifee; Matthew F Bush; Michele Pagano; Ning Zheng
Journal:  Nature       Date:  2013-03-17       Impact factor: 49.962

9.  Crystal structure of mammalian cryptochrome in complex with a small molecule competitor of its ubiquitin ligase.

Authors:  Shannon Nangle; Weiman Xing; Ning Zheng
Journal:  Cell Res       Date:  2013-10-01       Impact factor: 25.617

10.  An evolutionary hotspot defines functional differences between CRYPTOCHROMES.

Authors:  Clark Rosensweig; Kimberly A Reynolds; Peng Gao; Isara Laothamatas; Yongli Shan; Rama Ranganathan; Joseph S Takahashi; Carla B Green
Journal:  Nat Commun       Date:  2018-03-19       Impact factor: 14.919
  10 in total
  2 in total

1.  Mechanistic insight into light-dependent recognition of Timeless by Drosophila Cryptochrome.

Authors:  Changfan Lin; Connor M Schneps; Siddarth Chandrasekaran; Abir Ganguly; Brian R Crane
Journal:  Structure       Date:  2022-04-08       Impact factor: 5.871

2.  Structural differences in the FAD-binding pockets and lid loops of mammalian CRY1 and CRY2 for isoform-selective regulation.

Authors:  Simon Miller; Ashutosh Srivastava; Yoshiko Nagai; Yoshiki Aikawa; Florence Tama; Tsuyoshi Hirota
Journal:  Proc Natl Acad Sci U S A       Date:  2021-06-29       Impact factor: 11.205
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.