P Sgrò1, C Minganti2, M Lista3, C Antinozzi3, M Cappa4, Y Pitsiladis5, F Pigozzi2, L Di Luigi3. 1. Unit of Endocrinology, Department of Movement, Human and Health Sciences, Università degli Studi di Roma "Foro Italico", Piazza Lauro de Bosis 15, 00135, Roma, Italy. paolo.sgro@uniroma4.it. 2. Unit of Sport Medicine, Department of Movement, Human and Health Sciences, Università degli Studi di Roma "Foro Italico", Roma, Italy. 3. Unit of Endocrinology, Department of Movement, Human and Health Sciences, Università degli Studi di Roma "Foro Italico", Piazza Lauro de Bosis 15, 00135, Roma, Italy. 4. Unit of Endocrinology, Bambino Gesù Children's Hospital, Roma, Italy. 5. Collaborating Centre of Sports Medicine, University of Brighton, Welkin House, Eastbourne, UK.
Abstract
PURPOSE: Few data exist on dihydrotestosterone (DHT) adaptation to exercise-related stress. The aim of the study was to investigate on serum DHT and other androgens' responses to acute aerobic exercises, and to verify if a long-acting phosphodiesterase's type 5 inhibitors could influence these responses, as previously observed for salivary testosterone. METHODS: In a double-blind cross over study, 12 healthy trained male volunteers were submitted to both an acute sub-maximal and maximal exercise tests on cycle ergometer, after randomly receiving a two days placebo or tadalafil administration (20 mg, Cialis®, Ely-Lilly, Indianapolis, IN, USA). Blood sample collections were performed at different time points before and after exercise. Serum DHT, total testosterone (TT), dehydroepiandrosterone sulfate (DHEAS) and luteinizing hormone (LH), were assayed. RESULTS:Serum DHT increase in placebo treatment immediately post maximal aerobic exercise and return to basal values at 60 min of recovery whereas tadalafil administration significantly reduced the DHT increase after exercise. The values of areas under curves showed the increase of TT after acute sub-maximal and maximal exercise and of DHEAS only after acute maximal aerobic exercise independently from treatment. CONCLUSIONS: In addition to testosterone, also DHT plays an exercise-related adaptive role during high intensity aerobic exercise, but its rapid useful effects during exercise have to be determined. We hypothesized that the increased androgens secretion during exercise could be mainly related to steroidogenic enzymes modifications in peripheral tissues (i.e., muscles). Moreover, the blunting effect of tadalafil on DHT increase support a possible role of peripheral nitric oxide/GMPc related pathways in influencing physical-stress related DHT metabolism.
RCT Entities:
PURPOSE: Few data exist on dihydrotestosterone (DHT) adaptation to exercise-related stress. The aim of the study was to investigate on serum DHT and other androgens' responses to acute aerobic exercises, and to verify if a long-acting phosphodiesterase's type 5 inhibitors could influence these responses, as previously observed for salivary testosterone. METHODS: In a double-blind cross over study, 12 healthy trained male volunteers were submitted to both an acute sub-maximal and maximal exercise tests on cycle ergometer, after randomly receiving a two days placebo or tadalafil administration (20 mg, Cialis®, Ely-Lilly, Indianapolis, IN, USA). Blood sample collections were performed at different time points before and after exercise. Serum DHT, total testosterone (TT), dehydroepiandrosterone sulfate (DHEAS) and luteinizing hormone (LH), were assayed. RESULTS: Serum DHT increase in placebo treatment immediately post maximal aerobic exercise and return to basal values at 60 min of recovery whereas tadalafil administration significantly reduced the DHT increase after exercise. The values of areas under curves showed the increase of TT after acute sub-maximal and maximal exercise and of DHEAS only after acute maximal aerobic exercise independently from treatment. CONCLUSIONS: In addition to testosterone, also DHT plays an exercise-related adaptive role during high intensity aerobic exercise, but its rapid useful effects during exercise have to be determined. We hypothesized that the increased androgens secretion during exercise could be mainly related to steroidogenic enzymes modifications in peripheral tissues (i.e., muscles). Moreover, the blunting effect of tadalafil on DHT increase support a possible role of peripheral nitric oxide/GMPc related pathways in influencing physical-stress related DHT metabolism.
Authors: Jakob L Vingren; William J Kraemer; Nicholas A Ratamess; Jeffrey M Anderson; Jeff S Volek; Carl M Maresh Journal: Sports Med Date: 2010-12-01 Impact factor: 11.136
Authors: Francesco Felici; Ilenia Bazzucchi; Paolo Sgrò; Federico Quinzi; Alessandra Conti; Antonio Aversa; Leonardo Gizzi; Marco Mezzullo; Francesco Romanelli; Renato Pasquali; Andrea Lenzi; Luigi Di Luigi Journal: J Electromyogr Kinesiol Date: 2015-12-19 Impact factor: 2.368
Authors: C Antinozzi; F Marampon; C Corinaldesi; E Vicini; P Sgrò; G B Vannelli; A Lenzi; C Crescioli; L Di Luigi Journal: J Endocrinol Invest Date: 2017-05-15 Impact factor: 4.256
Authors: Cristina Antinozzi; Guglielmo Duranti; Roberta Ceci; Marco Lista; Stefania Sabatini; Daniela Caporossi; Luigi Di Luigi; Paolo Sgrò; Ivan Dimauro Journal: Int J Mol Sci Date: 2022-06-12 Impact factor: 6.208