Xiaoying Liu1, Yihui Liu2, Julia Mathers1, Melissa Cameron1, Itamar Levinger3,4, Bu B Yeap5,6, Joshua R Lewis5,7,8, Kaye E Brock1, Tara C Brennan-Speranza9,10. 1. Department of Physiology, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia. 2. School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, 2006, Australia. 3. Institute for Health and Sport (IHES), Victoria University, Melbourne, Australia. 4. Australian Institute for Musculoskeletal Science (AIMSS), Department of Medicine-Western Health, Melbourne Medical School, The University of Melbourne, Melbourne, Australia. 5. Medical School, University of Western Australia, Perth, Australia. 6. Department of Endocrinology and Diabetes, Fiona Stanley Hospital, Perth, Australia. 7. Centre for Kidney Research, Children's Hospital at Westmead, School of Public Health, Sydney Medical School, The University of Sydney, Sydney, Australia. 8. School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia. 9. Department of Physiology, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia. tara.speranza@sydney.edu.au. 10. School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, 2006, Australia. tara.speranza@sydney.edu.au.
Abstract
Osteocalcin, the osteoblast-derived protein, has been shown to be modulated in patients with problematic glucose metabolism. Our systematic review and meta-analysis found that in humans, higher blood osteocalcin level is associated with lower body indices of fat. PURPOSE/ INTRODUCTION: Osteocalcin (OC) was found to be inversely correlated with measures of glucose and energy metabolism, with some groups suggesting the undercarboxylated form (ucOC) to be metabolically active, although the link is not clear, especially in humans. Given obesity is a major risk factor for metabolic disorders, we aimed to assess the correlation between OC and two measures of body weight: body mass index (BMI) and percentage body fat (%BF). METHODS: MEDLINE and EMBASE were searched to identify observational studies in adult populations that reported the crude correlation coefficients (r) between OC and BMI and %BF. Pool r were obtained using random-effects models. RESULTS: Fifty-one publications were included in this analysis. Both total OC (TOC) (pooled r = - 0.151, 95% CI - 0.17, - 0.130; I2 = 52%) and ucOC (pooled r = - 0.060, 95% CI - 0.103, - 0.016; I2 = 54%) were inversely correlated with BMI. The pooled r between TOC and BMI in Caucasian-and-other-regions (r = - 0.187) were stronger than those in Asian populations (r = - 0.126; intra-group p = 0.002; R2 = 0.21). The mean/median BMI of the reported cohort was the major contributor to between-study heterogeneity in correlation between TOC/ucOC and BMI (R2 = 0.28 and 0.77, respectively). Both TOC and ucOC were also inversely correlated with %BF (TOC: pooled r = - 0.185, 95% CI - 0.257 to - 0.112; ucOC: pooled r = - 0.181, 95% CI - 0.258 to - 0.101). CONCLUSION: Higher OC and ucOC were correlated with lower BMI and %BF. The inverse correlations between TOC/ucOC and BMI appear to be affected by ethnicity and obesity status.
Osteocalcin, the osteoblast-derived protein, has been shown to be modulated in patients with problematic glucose metabolism. Our systematic review and meta-analysis found that in humans, higher blood osteocalcin level is associated with lower body indices of fat. PURPOSE/ INTRODUCTION:Osteocalcin (OC) was found to be inversely correlated with measures of glucose and energy metabolism, with some groups suggesting the undercarboxylated form (ucOC) to be metabolically active, although the link is not clear, especially in humans. Given obesity is a major risk factor for metabolic disorders, we aimed to assess the correlation between OC and two measures of body weight: body mass index (BMI) and percentage body fat (%BF). METHODS: MEDLINE and EMBASE were searched to identify observational studies in adult populations that reported the crude correlation coefficients (r) between OC and BMI and %BF. Pool r were obtained using random-effects models. RESULTS: Fifty-one publications were included in this analysis. Both total OC (TOC) (pooled r = - 0.151, 95% CI - 0.17, - 0.130; I2 = 52%) and ucOC (pooled r = - 0.060, 95% CI - 0.103, - 0.016; I2 = 54%) were inversely correlated with BMI. The pooled r between TOC and BMI in Caucasian-and-other-regions (r = - 0.187) were stronger than those in Asian populations (r = - 0.126; intra-group p = 0.002; R2 = 0.21). The mean/median BMI of the reported cohort was the major contributor to between-study heterogeneity in correlation between TOC/ucOC and BMI (R2 = 0.28 and 0.77, respectively). Both TOC and ucOC were also inversely correlated with %BF (TOC: pooled r = - 0.185, 95% CI - 0.257 to - 0.112; ucOC: pooled r = - 0.181, 95% CI - 0.258 to - 0.101). CONCLUSION: Higher OC and ucOC were correlated with lower BMI and %BF. The inverse correlations between TOC/ucOC and BMI appear to be affected by ethnicity and obesity status.
Entities:
Keywords:
Adiposity; Body fat percentage; Body mass index; Osteocalcin
Authors: Emily R Cox; Wendy J Brown; Trishan Gajanand; Tom G Bailey; Sjaan R Gomersall; Veronique S Chachay; Nicola W Burton; Robert G Fassett; Stephen V Cox; Jeff S Coombes; Shelley E Keating Journal: Clin Obes Date: 2022-03-15
Authors: Elis Bartečků; Jana Hořínková; Pavel Křenek; Alena Damborská; Josef Tomandl; Marie Tomandlová; Jan Kučera; Jana Fialová Kučerová; Julie Bienertová-Vašků Journal: Front Psychiatry Date: 2022-08-02 Impact factor: 5.435
Authors: Arnold Z Olali; Anjali Sharma; Qiuhu Shi; Donald R Hoover; Kathleen M Weber; Audrey L French; Heather S McKay; Phyllis C Tien; Lena Al-Harthi; Michael T Yin; Ryan D Ross Journal: J Acquir Immune Defic Syndr Date: 2021-04-15 Impact factor: 3.771