Literature DB >> 32945867

Harnessing technology and portability to conduct molecular epidemiology of endemic pathogens in resource-limited settings.

Christina L Faust1,2, Kirstyn Brunker1, Diana Ajambo3, Mary Ryan4, Arinaitwe Moses3, Candia Rowel3, Robert Mandela Wangoola5, Eddie M Wampande6, Andrew Guma3, Moses Adriko3, Poppy H L Lamberton1,2, Edridah M Tukahebwa3, Albert Mugenyi5, Charles Waiswa5.   

Abstract

Improvements in genetic and genomic technology have enabled field-deployable molecular laboratories and these have been deployed in a variety of epidemics that capture headlines. In this editorial, we highlight the importance of building physical and personnel capacity in low and middle income countries to deploy these technologies to improve diagnostics, understand transmission dynamics and provide feedback to endemic communities on actionable timelines. We describe our experiences with molecular field research on schistosomiasis, trypanosomiasis and rabies and urge the wider tropical medicine community to embrace these methods and help build capacity to benefit communities affected by endemic infectious diseases.
© The Author(s) 2020. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene.

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Year:  2021        PMID: 32945867      PMCID: PMC7788292          DOI: 10.1093/trstmh/traa086

Source DB:  PubMed          Journal:  Trans R Soc Trop Med Hyg        ISSN: 0035-9203            Impact factor:   2.184


  6 in total

1.  Tree Lab: Portable genomics for Early Detection of Plant Viruses and Pests in Sub-Saharan Africa.

Authors:  Laura M Boykin; Peter Sseruwagi; Titus Alicai; Elijah Ateka; Ibrahim Umar Mohammed; Jo-Ann L Stanton; Charles Kayuki; Deogratius Mark; Tarcisius Fute; Joel Erasto; Hilda Bachwenkizi; Brenda Muga; Naomi Mumo; Jenniffer Mwangi; Phillip Abidrabo; Geoffrey Okao-Okuja; Geresemu Omuut; Jacinta Akol; Hellen B Apio; Francis Osingada; Monica A Kehoe; David Eccles; Anders Savill; Stephen Lamb; Tonny Kinene; Christopher B Rawle; Abishek Muralidhar; Kirsty Mayall; Fred Tairo; Joseph Ndunguru
Journal:  Genes (Basel)       Date:  2019-08-21       Impact factor: 4.096

2.  Influenza A Virus Field Surveillance at a Swine-Human Interface.

Authors:  Benjamin L Rambo-Martin; Matthew W Keller; Malania M Wilson; Jacqueline M Nolting; Tavis K Anderson; Amy L Vincent; Ujwal R Bagal; Yunho Jang; Elizabeth B Neuhaus; C Todd Davis; Andrew S Bowman; David E Wentworth; John R Barnes
Journal:  mSphere       Date:  2020-02-05       Impact factor: 4.389

3.  Developing reproducible bioinformatics analysis workflows for heterogeneous computing environments to support African genomics.

Authors:  Shakuntala Baichoo; Yassine Souilmi; Sumir Panji; Gerrit Botha; Ayton Meintjes; Scott Hazelhurst; Hocine Bendou; Eugene de Beste; Phelelani T Mpangase; Oussema Souiai; Mustafa Alghali; Long Yi; Brian D O'Connor; Michael Crusoe; Don Armstrong; Shaun Aron; Fourie Joubert; Azza E Ahmed; Mamana Mbiyavanga; Peter van Heusden; Lerato E Magosi; Jennie Zermeno; Liudmila Sergeevna Mainzer; Faisal M Fadlelmola; C Victor Jongeneel; Nicola Mulder
Journal:  BMC Bioinformatics       Date:  2018-11-29       Impact factor: 3.169

4.  Integrating whole-genome sequencing within the National Antimicrobial Resistance Surveillance Program in the Philippines.

Authors:  David M Aanensen; Celia C Carlos; Silvia Argimón; Melissa A L Masim; June M Gayeta; Marietta L Lagrada; Polle K V Macaranas; Victoria Cohen; Marilyn T Limas; Holly O Espiritu; Janziel C Palarca; Jeremiah Chilam; Manuel C Jamoralin; Alfred S Villamin; Janice B Borlasa; Agnettah M Olorosa; Lara F T Hernandez; Karis D Boehme; Benjamin Jeffrey; Khalil Abudahab; Charmian M Hufano; Sonia B Sia; John Stelling; Matthew T G Holden
Journal:  Nat Commun       Date:  2020-06-01       Impact factor: 14.919

5.  Real-time, portable genome sequencing for Ebola surveillance.

Authors:  Joshua Quick; Nicholas J Loman; Sophie Duraffour; Jared T Simpson; Ettore Severi; Lauren Cowley; Joseph Akoi Bore; Raymond Koundouno; Gytis Dudas; Amy Mikhail; Nobila Ouédraogo; Babak Afrough; Amadou Bah; Jonathan Hj Baum; Beate Becker-Ziaja; Jan-Peter Boettcher; Mar Cabeza-Cabrerizo; Alvaro Camino-Sanchez; Lisa L Carter; Juiliane Doerrbecker; Theresa Enkirch; Isabel Graciela García Dorival; Nicole Hetzelt; Julia Hinzmann; Tobias Holm; Liana Eleni Kafetzopoulou; Michel Koropogui; Abigail Kosgey; Eeva Kuisma; Christopher H Logue; Antonio Mazzarelli; Sarah Meisel; Marc Mertens; Janine Michel; Didier Ngabo; Katja Nitzsche; Elisa Pallash; Livia Victoria Patrono; Jasmine Portmann; Johanna Gabriella Repits; Natasha Yasmin Rickett; Andrea Sachse; Katrin Singethan; Inês Vitoriano; Rahel L Yemanaberhan; Elsa G Zekeng; Racine Trina; Alexander Bello; Amadou Alpha Sall; Ousmane Faye; Oumar Faye; N'Faly Magassouba; Cecelia V Williams; Victoria Amburgey; Linda Winona; Emily Davis; Jon Gerlach; Franck Washington; Vanessa Monteil; Marine Jourdain; Marion Bererd; Alimou Camara; Hermann Somlare; Abdoulaye Camara; Marianne Gerard; Guillaume Bado; Bernard Baillet; Déborah Delaune; Koumpingnin Yacouba Nebie; Abdoulaye Diarra; Yacouba Savane; Raymond Bernard Pallawo; Giovanna Jaramillo Gutierrez; Natacha Milhano; Isabelle Roger; Christopher J Williams; Facinet Yattara; Kuiama Lewandowski; Jamie Taylor; Philip Rachwal; Daniel Turner; Georgios Pollakis; Julian A Hiscox; David A Matthews; Matthew K O'Shea; Andrew McD Johnston; Duncan Wilson; Emma Hutley; Erasmus Smit; Antonino Di Caro; Roman Woelfel; Kilian Stoecker; Erna Fleischmann; Martin Gabriel; Simon A Weller; Lamine Koivogui; Boubacar Diallo; Sakoba Keita; Andrew Rambaut; Pierre Formenty; Stephan Gunther; Miles W Carroll
Journal:  Nature       Date:  2016-02-03       Impact factor: 69.504

6.  Rapid in-country sequencing of whole virus genomes to inform rabies elimination programmes.

Authors:  Kirstyn Brunker; Gurdeep Jaswant; S M Thumbi; Kennedy Lushasi; Ahmed Lugelo; Anna M Czupryna; Fred Ade; Gati Wambura; Veronicah Chuchu; Rachel Steenson; Chanasa Ngeleja; Criselda Bautista; Daria L Manalo; Ma Ricci R Gomez; Maria Yna Joyce V Chu; Mary Elizabeth Miranda; Maya Kamat; Kristyna Rysava; Jason Espineda; Eva Angelica V Silo; Ariane Mae Aringo; Rona P Bernales; Florencio F Adonay; Michael J Tildesley; Denise A Marston; Daisy L Jennings; Anthony R Fooks; Wenlong Zhu; Luke W Meredith; Sarah C Hill; Radoslaw Poplawski; Robert J Gifford; Joshua B Singer; Mathew Maturi; Athman Mwatondo; Roman Biek; Katie Hampson
Journal:  Wellcome Open Res       Date:  2020-05-19
  6 in total

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