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Literature DB >> 32944640

SOX6: a double-edged sword for Ewing sarcoma.

Aruna Marchetto¹, Thomas G P Grünewald^1,2,3,4.

Abstract

Developmental pathways play an important role in cancer. We have recently demonstrated that the constitutive activation of the developmental transcription factor SOX6 via the fusion oncoproteinne EWSR1-FLI1 (Ewing sarcoma breakpoint region 1 - Friend leukemia virus integration 1) contributes to the aggressive phenotype of Ewing sarcoma but on another hand provides an opportunity for targeted therapy.

Entities: Disease Gene

Keywords: EWSR1-FLI1; Elesclomol; Ewing sarcoma; SOX6; biomarker; oxidative-stress; vulnerability

Year: 2020 PMID： 32944640 PMCID： PMC7469519 DOI： 10.1080/23723556.2020.1783081

Source DB: PubMed Journal: Mol Cell Oncol ISSN： 2372-3556

9 in total

Review 1. Ewing sarcoma.

Authors: Thomas G P Grünewald; Florencia Cidre-Aranaz; Didier Surdez; Eleni M Tomazou; Enrique de Álava; Heinrich Kovar; Poul H Sorensen; Olivier Delattre; Uta Dirksen
Journal: Nat Rev Dis Primers Date: 2018-07-05 Impact factor: 52.329

Review 2. Roles of thioredoxin binding protein (TXNIP) in oxidative stress, apoptosis and cancer.

Authors: Jianbiao Zhou; Wee-Joo Chng
Journal: Mitochondrion Date: 2012-06-27 Impact factor: 4.160

3. Elesclomol, counteracted by Akt survival signaling, enhances the apoptotic effect of chemotherapy drugs in breast cancer cells.

Authors: Ying Qu; Jinhua Wang; Myung-Shin Sim; Bingya Liu; Armando Giuliano; James Barsoum; Xiaojiang Cui
Journal: Breast Cancer Res Treat Date: 2009-07-16 Impact factor: 4.872

4. Chimeric EWSR1-FLI1 regulates the Ewing sarcoma susceptibility gene EGR2 via a GGAA microsatellite.

Authors: Thomas G P Grünewald; Virginie Bernard; Pascale Gilardi-Hebenstreit; Virginie Raynal; Didier Surdez; Marie-Ming Aynaud; Olivier Mirabeau; Florencia Cidre-Aranaz; Franck Tirode; Sakina Zaidi; Gaëlle Perot; Anneliene H Jonker; Carlo Lucchesi; Marie-Cécile Le Deley; Odile Oberlin; Perrine Marec-Bérard; Amélie S Véron; Stephanie Reynaud; Eve Lapouble; Valentina Boeva; Thomas Rio Frio; Javier Alonso; Smita Bhatia; Gaëlle Pierron; Geraldine Cancel-Tassin; Olivier Cussenot; David G Cox; Lindsay M Morton; Mitchell J Machiela; Stephen J Chanock; Patrick Charnay; Olivier Delattre
Journal: Nat Genet Date: 2015-07-27 Impact factor: 38.330

5. Elesclomol induces cancer cell apoptosis through oxidative stress.

Authors: Jessica R Kirshner; Suqin He; Vishwasenani Balasubramanyam; Jane Kepros; Chin-Yu Yang; Mei Zhang; Zhenjian Du; James Barsoum; John Bertin
Journal: Mol Cancer Ther Date: 2008-08 Impact factor: 6.261

6. Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes.

Authors: Julian Musa; Florencia Cidre-Aranaz; Marie-Ming Aynaud; Martin F Orth; Maximilian M L Knott; Olivier Mirabeau; Gal Mazor; Mor Varon; Tilman L B Hölting; Sandrine Grossetête; Moritz Gartlgruber; Didier Surdez; Julia S Gerke; Shunya Ohmura; Aruna Marchetto; Marlene Dallmayer; Michaela C Baldauf; Stefanie Stein; Giuseppina Sannino; Jing Li; Laura Romero-Pérez; Frank Westermann; Wolfgang Hartmann; Uta Dirksen; Melissa Gymrek; Nathaniel D Anderson; Adam Shlien; Barak Rotblat; Thomas Kirchner; Olivier Delattre; Thomas G P Grünewald
Journal: Nat Commun Date: 2019-09-11 Impact factor: 14.919

7. Sox5 and Sox6 are needed to develop and maintain source, columnar, and hypertrophic chondrocytes in the cartilage growth plate.

Authors: Patrick Smits; Peter Dy; Srijeet Mitra; Véronique Lefebvre
Journal: J Cell Biol Date: 2004-03-01 Impact factor: 10.539

8. Clinical and biochemical function of polymorphic NR0B1 GGAA-microsatellites in Ewing sarcoma: a report from the Children's Oncology Group.

Authors: Michael J Monument; Kirsten M Johnson; Elizabeth McIlvaine; Lisa Abegglen; W Scott Watkins; Lynn B Jorde; Richard B Womer; Natalie Beeler; Laura Monovich; Elizabeth R Lawlor; Julia A Bridge; Joshua D Schiffman; Mark D Krailo; R Lor Randall; Stephen L Lessnick
Journal: PLoS One Date: 2014-08-05 Impact factor: 3.240

9. Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma.

Authors: Aruna Marchetto; Shunya Ohmura; Martin F Orth; Maximilian M L Knott; Maria V Colombo; Chiara Arrigoni; Victor Bardinet; David Saucier; Fabienne S Wehweck; Jing Li; Stefanie Stein; Julia S Gerke; Michaela C Baldauf; Julian Musa; Marlene Dallmayer; Laura Romero-Pérez; Tilman L B Hölting; James F Amatruda; Andrea Cossarizza; Anton G Henssen; Thomas Kirchner; Matteo Moretti; Florencia Cidre-Aranaz; Giuseppina Sannino; Thomas G P Grünewald
Journal: Nat Commun Date: 2020-05-15 Impact factor: 14.919