Literature DB >> 32944637

The spliceosome as a new therapeutic vulnerability in aggressive prostate cancer.

Cheng Zou1, Dingxiao Zhang1.   

Abstract

Alternative splicing (AS) analysis across the entire spectrum of human prostate cancer evolution reveals the unexpected findings that intron retention is a hallmark of stemness and tumor aggressiveness, and androgen receptor controls a splicing program distinct from its transcriptional regulation. Importantly, twisted activity of the spliceosome causing abnormal AS landscape represents a therapeutic vulnerability in aggressive prostate cancer.
© 2020 Taylor & Francis Group, LLC.

Entities:  

Keywords:  Alternative splicing; CRPC; E7107; cancer treatment; prostate cancer; spliceosome

Year:  2020        PMID： 32944637      PMCID： PMC7469601          DOI： 10.1080/23723556.2020.1778420

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  8 in total

1.  Exome sequencing identifies a spectrum of mutation frequencies in advanced and lethal prostate cancers.

Authors:  Akash Kumar; Thomas A White; Alexandra P MacKenzie; Nigel Clegg; Choli Lee; Ruth F Dumpit; Ilsa Coleman; Sarah B Ng; Stephen J Salipante; Mark J Rieder; Deborah A Nickerson; Eva Corey; Paul H Lange; Colm Morrissey; Robert L Vessella; Peter S Nelson; Jay Shendure
Journal:  Proc Natl Acad Sci U S A       Date:  2011-09-26       Impact factor: 11.205

Review 2.  Therapeutic targeting of splicing in cancer.

Authors:  Stanley Chun-Wei Lee; Omar Abdel-Wahab
Journal:  Nat Med       Date:  2016-09-07       Impact factor: 53.440

3.  Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients.

Authors:  André Kahles; Kjong-Van Lehmann; Nora C Toussaint; Matthias Hüser; Stefan G Stark; Timo Sachsenberg; Oliver Stegle; Oliver Kohlbacher; Chris Sander; Gunnar Rätsch
Journal:  Cancer Cell       Date:  2018-08-02       Impact factor: 31.743

4.  Stem cell and neurogenic gene-expression profiles link prostate basal cells to aggressive prostate cancer.

Authors:  Dingxiao Zhang; Daechan Park; Yi Zhong; Yue Lu; Kiera Rycaj; Shuai Gong; Xin Chen; Xin Liu; Hsueh-Ping Chao; Pamela Whitney; Tammy Calhoun-Davis; Yoko Takata; Jianjun Shen; Vishwanath R Iyer; Dean G Tang
Journal:  Nat Commun       Date:  2016-02-29       Impact factor: 14.919

5.  Multipotent Basal Stem Cells, Maintained in Localized Proximal Niches, Support Directed Long-Ranging Epithelial Flows in Human Prostates.

Authors:  Mohammad Moad; Edouard Hannezo; Simon J Buczacki; Laura Wilson; Amira El-Sherif; David Sims; Robert Pickard; Nicholas A Wright; Stuart C Williamson; Doug M Turnbull; Robert W Taylor; Laura Greaves; Craig N Robson; Benjamin D Simons; Rakesh Heer
Journal:  Cell Rep       Date:  2017-08-15       Impact factor: 9.423

6.  Intron retention is a hallmark and spliceosome represents a therapeutic vulnerability in aggressive prostate cancer.

Authors:  Dingxiao Zhang; Qiang Hu; Xiaozhuo Liu; Yibing Ji; Hsueh-Ping Chao; Yan Liu; Amanda Tracz; Jason Kirk; Silvia Buonamici; Ping Zhu; Jianmin Wang; Song Liu; Dean G Tang
Journal:  Nat Commun       Date:  2020-04-29       Impact factor: 14.919

7.  Nuclear Pores Promote Lethal Prostate Cancer by Increasing POM121-Driven E2F1, MYC, and AR Nuclear Import.

Authors:  Veronica Rodriguez-Bravo; Raffaella Pippa; Won-Min Song; Marc Carceles-Cordon; Ana Dominguez-Andres; Naoto Fujiwara; Jungreem Woo; Anna P Koh; Adam Ertel; Ravi K Lokareddy; Alvaro Cuesta-Dominguez; Rosa S Kim; Irene Rodriguez-Fernandez; Peiyao Li; Ronald Gordon; Hadassa Hirschfield; Josep M Prats; E Premkumar Reddy; Alessandro Fatatis; Daniel P Petrylak; Leonard Gomella; W Kevin Kelly; Scott W Lowe; Karen E Knudsen; Matthew D Galsky; Gino Cingolani; Amaia Lujambio; Yujin Hoshida; Josep Domingo-Domenech
Journal:  Cell       Date:  2018-08-09       Impact factor: 66.850

8.  Systematic Analysis of Splice-Site-Creating Mutations in Cancer.

Authors:  Reyka G Jayasinghe; Song Cao; Qingsong Gao; Michael C Wendl; Nam Sy Vo; Sheila M Reynolds; Yanyan Zhao; Héctor Climente-González; Shengjie Chai; Fang Wang; Rajees Varghese; Mo Huang; Wen-Wei Liang; Matthew A Wyczalkowski; Sohini Sengupta; Zhi Li; Samuel H Payne; David Fenyö; Jeffrey H Miner; Matthew J Walter; Benjamin Vincent; Eduardo Eyras; Ken Chen; Ilya Shmulevich; Feng Chen; Li Ding
Journal:  Cell Rep       Date:  2018-04-03       Impact factor: 9.423
  8 in total

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