Literature DB >> 32944629

Translation control can shape TP53-dependent cell fate.

Dario Rizzotto1, Sara Zaccara1, Annalisa Rossi1, Erik Dassi1, Alberto Inga1.   

Abstract

The search for mechanisms underlying different cellular responses to the treatment with Nutlin-3, an MDM2 inhibitor that unleashes p53, revealed a translational control mechanism involving the RNA binding proteins PCBP2 and, particularly, DHX30. Sifting through a multi-functional p53-dependent transcriptional output, this translational control can modulate the activation of cell death pathways.
© 2020 Taylor & Francis Group, LLC.

Entities:  

Keywords:  DHX30; PCBP2; apoptosis; p53; polysomal profiling; transcription; translation; translatome

Year:  2020        PMID： 32944629      PMCID： PMC7469437          DOI： 10.1080/23723556.2020.1767483

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  9 in total

Review 1.  p53, a translational regulator: contribution to its tumour-suppressor activity.

Authors:  V Marcel; F Catez; J-J Diaz
Journal:  Oncogene       Date:  2015-03-02       Impact factor: 9.867

Review 2.  p53: puzzle and paradigm.

Authors:  L J Ko; C Prives
Journal:  Genes Dev       Date:  1996-05-01       Impact factor: 11.361

3.  p53-directed translational control can shape and expand the universe of p53 target genes.

Authors:  S Zaccara; T Tebaldi; C Pederiva; Y Ciribilli; A Bisio; A Inga
Journal:  Cell Death Differ       Date:  2014-06-13       Impact factor: 15.828

4.  Regulation of p53 stability by Mdm2.

Authors:  M H Kubbutat; S N Jones; K H Vousden
Journal:  Nature       Date:  1997-05-15       Impact factor: 49.962

Review 5.  p53--a Jack of all trades but master of none.

Authors:  Melissa R Junttila; Gerard I Evan
Journal:  Nat Rev Cancer       Date:  2009-09-24       Impact factor: 60.716

6.  CaMKII versus DAPK1 Binding to GluN2B in Ischemic Neuronal Cell Death after Resuscitation from Cardiac Arrest.

Authors:  Olivia R Buonarati; Sarah G Cook; Dayton J Goodell; Nicholas E Chalmers; Nicole L Rumian; Jonathan E Tullis; Susana Restrepo; Steven J Coultrap; Nidia Quillinan; Paco S Herson; K Ulrich Bayer
Journal:  Cell Rep       Date:  2020-01-07       Impact factor: 9.423

Review 7.  Putting p53 in Context.

Authors:  Edward R Kastenhuber; Scott W Lowe
Journal:  Cell       Date:  2017-09-07       Impact factor: 41.582

8.  Identification of a core TP53 transcriptional program with highly distributed tumor suppressive activity.

Authors:  Zdenek Andrysik; Matthew D Galbraith; Anna L Guarnieri; Sara Zaccara; Kelly D Sullivan; Ahwan Pandey; Morgan MacBeth; Alberto Inga; Joaquín M Espinosa
Journal:  Genome Res       Date:  2017-09-13       Impact factor: 9.043

9.  Revealing a human p53 universe.

Authors:  Thuy-Ai T Nguyen; Sara A Grimm; Pierre R Bushel; Jianying Li; Yuanyuan Li; Brian D Bennett; Christopher A Lavender; James M Ward; David C Fargo; Carl W Anderson; Leping Li; Michael A Resnick; Daniel Menendez
Journal:  Nucleic Acids Res       Date:  2018-09-19       Impact factor: 16.971
  9 in total
  1 in total

1.  Poly(C)-binding Protein 2 Regulates the p53 Expression via Interactions with the 5'-Terminal Region of p53 mRNA.

Authors:  Damian M Janecki; Agata Swiatkowska; Joanna Szpotkowska; Anna Urbanowicz; Martyna Kabacińska; Kamil Szpotkowski; Jerzy Ciesiołka
Journal:  Int J Mol Sci       Date:  2021-12-10       Impact factor: 5.923
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.