Literature DB >> 32944628

ARF6 controls RHOB targeting to endosomes regulating cancer cell invasion.

Kossay Zaoui1,2, Harvey Wilmore Smith1, Morag Park1,2,3,4, Stéphanie Duhamel1.   

Abstract

Endocytic trafficking has emerged as an essential mechanism to spatiotemporally coordinate signaling protein complexes that control cytoskeletal dynamics and cell motility. Our study established an unexpected regulatory mechanism whereby ADP ribosylation factors 6 (ARF6) controls the stability and endosomal localization of RAS homologous protein B (RHOB) to regulate cell invasion downstream of the oncogenic receptor tyrosine kinase, MET.
© 2020 Taylor & Francis Group, LLC.

Entities:  

Keywords:  ARF6; Cell invasion; MET receptor tyrosine kinase; RHO GTPase; RHOB

Year:  2020        PMID： 32944628      PMCID： PMC7469434          DOI： 10.1080/23723556.2020.1766932

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  9 in total

Review 1.  Cell migration: integrating signals from front to back.

Authors:  Anne J Ridley; Martin A Schwartz; Keith Burridge; Richard A Firtel; Mark H Ginsberg; Gary Borisy; J Thomas Parsons; Alan Rick Horwitz
Journal:  Science       Date:  2003-12-05       Impact factor: 47.728

Review 2.  Targeting MET in cancer: rationale and progress.

Authors:  Ermanno Gherardi; Walter Birchmeier; Carmen Birchmeier; George Vande Woude
Journal:  Nat Rev Cancer       Date:  2012-01-24       Impact factor: 60.716

Review 3.  ARF proteins: roles in membrane traffic and beyond.

Authors:  Crislyn D'Souza-Schorey; Philippe Chavrier
Journal:  Nat Rev Mol Cell Biol       Date:  2006-05       Impact factor: 94.444

Review 4.  Why three Rho proteins? RhoA, RhoB, RhoC, and cell motility.

Authors:  Ann P Wheeler; Anne J Ridley
Journal:  Exp Cell Res       Date:  2004-11-15       Impact factor: 3.905

5.  GGA3 functions as a switch to promote Met receptor recycling, essential for sustained ERK and cell migration.

Authors:  Christine Anna Parachoniak; Yi Luo; Jasmine Vanessa Abella; James H Keen; Morag Park
Journal:  Dev Cell       Date:  2011-06-14       Impact factor: 12.270

Review 6.  Crosstalk in Met receptor oncogenesis.

Authors:  Andrea Z Lai; Jasmine V Abella; Morag Park
Journal:  Trends Cell Biol       Date:  2009-09-14       Impact factor: 20.808

7.  Intracellular localization of the P21rho proteins.

Authors:  P Adamson; H F Paterson; A Hall
Journal:  J Cell Biol       Date:  1992-11       Impact factor: 10.539

8.  Arf6 regulates RhoB subcellular localization to control cancer cell invasion.

Authors:  Kossay Zaoui; Charles V Rajadurai; Stéphanie Duhamel; Morag Park
Journal:  J Cell Biol       Date:  2019-10-07       Impact factor: 10.539

9.  The C-terminal sequence of RhoB directs protein degradation through an endo-lysosomal pathway.

Authors:  Dolores Pérez-Sala; Patricia Boya; Irene Ramos; Mónica Herrera; Konstantinos Stamatakis
Journal:  PLoS One       Date:  2009-12-02       Impact factor: 3.240
  9 in total
  1 in total

Review 1.  MicroRNA Signatures in the Upper Urinary Tract Urothelial Carcinoma Scenario: Ready for the Game Changer?

Authors:  Alessandra Cinque; Anna Capasso; Riccardo Vago; Matteo Floris; Michael W Lee; Roberto Minnei; Francesco Trevisani
Journal:  Int J Mol Sci       Date:  2022-02-26       Impact factor: 5.923
  1 in total

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