Literature DB >> 32944624

Targeting neurolysin in acute myeloid leukemia.

Sara Mirali1,2, Aaron D Schimmer1,2.   

Abstract

We recently identified the mitochondrial peptidase, neurolysin (NLN), as a top hit in an acute myeloid leukemia (AML) viability screen. Using chemical and genetic approaches, we demonstrated that loss of NLN disrupted respiratory chain supercomplex assembly and impaired oxidative metabolism in AML. Moreover, inhibition of NLN in vitro and in vivo reduced the growth of AML cells.
© 2020 Taylor & Francis Group, LLC.

Entities:  

Keywords:  Acute myeloid leukemia; LETM1; metabolism; neurolysin; respiratory chain supercomplexes

Year:  2020        PMID： 32944624      PMCID： PMC7469488          DOI： 10.1080/23723556.2020.1761243

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  9 in total

1.  Neurolysin: purification and assays.

Authors:  F Checler; H Barelli; P Dauch; V Dive; B Vincent; J P Vincent
Journal:  Methods Enzymol       Date:  1995       Impact factor: 1.600

2.  Allosteric inhibition of the neuropeptidase neurolysin.

Authors:  Christina S Hines; Kallol Ray; Jack J Schmidt; Fei Xiong; Rolf W Feenstra; Mia Pras-Raves; Jan Peter de Moes; Jos H M Lange; Manana Melikishvili; Michael G Fried; Paul Mortenson; Michael Charlton; Yogendra Patel; Stephen M Courtney; Chris G Kruse; David W Rodgers
Journal:  J Biol Chem       Date:  2014-11-05       Impact factor: 5.157

3.  Progress towards a tobacco-free world.

Authors: 
Journal:  Lancet       Date:  2018-07-05       Impact factor: 79.321

4.  Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia.

Authors:  Daniel A Pollyea; Brett M Stevens; Courtney L Jones; Amanda Winters; Shanshan Pei; Mohammad Minhajuddin; Angelo D'Alessandro; Rachel Culp-Hill; Kent A Riemondy; Austin E Gillen; Jay R Hesselberth; Diana Abbott; Derek Schatz; Jonathan A Gutman; Enkhtsetseg Purev; Clayton Smith; Craig T Jordan
Journal:  Nat Med       Date:  2018-11-12       Impact factor: 53.440

5.  Neurolysin knockout mice generation and initial phenotype characterization.

Authors:  Diogo M L P Cavalcanti; Leandro M Castro; José C Rosa Neto; Marilia Seelaender; Rodrigo X Neves; Vitor Oliveira; Fábio L Forti; Leo K Iwai; Fabio C Gozzo; Mihail Todiras; Ines Schadock; Carlos C Barros; Michael Bader; Emer S Ferro
Journal:  J Biol Chem       Date:  2014-04-09       Impact factor: 5.157

6.  Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia.

Authors:  Alicia Cole; Zezhou Wang; Etienne Coyaud; Veronique Voisin; Marcela Gronda; Yulia Jitkova; Rachel Mattson; Rose Hurren; Sonja Babovic; Neil Maclean; Ian Restall; Xiaoming Wang; Danny V Jeyaraju; Mahadeo A Sukhai; Swayam Prabha; Shaheena Bashir; Ashwin Ramakrishnan; Elisa Leung; Yi Hua Qia; Nianxian Zhang; Kevin R Combes; Troy Ketela; Fengshu Lin; Walid A Houry; Ahmed Aman; Rima Al-Awar; Wei Zheng; Erno Wienholds; Chang Jiang Xu; John Dick; Jean C Y Wang; Jason Moffat; Mark D Minden; Connie J Eaves; Gary D Bader; Zhenyue Hao; Steven M Kornblau; Brian Raught; Aaron D Schimmer
Journal:  Cancer Cell       Date:  2015-06-08       Impact factor: 31.743

7.  Enhanced Respiratory Chain Supercomplex Formation in Response to Exercise in Human Skeletal Muscle.

Authors:  Chiara Greggio; Pooja Jha; Sameer S Kulkarni; Sylviane Lagarrigue; Nicholas T Broskey; Marie Boutant; Xu Wang; Sonia Conde Alonso; Emmanuel Ofori; Johan Auwerx; Carles Cantó; Francesca Amati
Journal:  Cell Metab       Date:  2016-12-01       Impact factor: 27.287

8.  Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia.

Authors:  Marko Skrtić; Shrivani Sriskanthadevan; Bozhena Jhas; Marinella Gebbia; Xiaoming Wang; Zezhou Wang; Rose Hurren; Yulia Jitkova; Marcela Gronda; Neil Maclean; Courteney K Lai; Yanina Eberhard; Justyna Bartoszko; Paul Spagnuolo; Angela C Rutledge; Alessandro Datti; Troy Ketela; Jason Moffat; Brian H Robinson; Jessie H Cameron; Jeffery Wrana; Connie J Eaves; Mark D Minden; Jean C Y Wang; John E Dick; Keith Humphries; Corey Nislow; Guri Giaever; Aaron D Schimmer
Journal:  Cancer Cell       Date:  2011-11-15       Impact factor: 31.743

9.  Characterization of the mitochondrial protein LETM1, which maintains the mitochondrial tubular shapes and interacts with the AAA-ATPase BCS1L.

Authors:  Shoko Tamai; Hiroshi Iida; Sadaki Yokota; Tomoko Sayano; Shoko Kiguchiya; Naotada Ishihara; Jun-Ichi Hayashi; Katsuyoshi Mihara; Toshihiko Oka
Journal:  J Cell Sci       Date:  2008-07-15       Impact factor: 5.285
  9 in total
  1 in total

1.  Measurable residual disease in elderly acute myeloid leukemia: results from the PETHEMA-FLUGAZA phase 3 clinical trial.

Authors:  Catia Simoes; Bruno Paiva; David Martínez-Cuadrón; Juan-Miguel Bergua; Susana Vives; Lorenzo Algarra; Mar Tormo; Pilar Martinez; Josefina Serrano; Pilar Herrera; Fernando Ramos; Olga Salamero; Esperanza Lavilla; Cristina Gil; Jose-Luis Lopez; Maria-Belen Vidriales; Jorge Labrador; Jose-Francisco Falantes; María-José Sayas; Rosa Ayala; Joaquin Martinez-Lopez; Sara Villar; Maria-Jose Calasanz; Felipe Prosper; Jesús F San-Miguel; Miguel Ángel Sanz; Pau Montesinos
Journal:  Blood Adv       Date:  2021-02-09
  1 in total

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