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Literature DB >> 32944623

Energy stress inhibits ferroptosis via AMPK.

Abstract

Energy stress disturbs cellular homeostasis and induces cell death. Our recent study revealed that ferroptosis (a non-apoptotic cell death) is an energy-requiring process, and energy stress-mediated activation of adenosine monophosphate-activated protein kinase (AMPK) inhibits ferroptosis. Mechanistically, AMPK regulates ferroptosis through acetyl-CoA carboxylase (ACC) and polyunsaturated fatty acid (PUFA) biosynthesis.

Entities: Chemical

Keywords: AMP-activated protein kinase; Energy stress; acetyl-CoA carboxylase; ferroptosis; polyunsaturated fatty acid

Year: 2020 PMID： 32944623 PMCID： PMC7469505 DOI： 10.1080/23723556.2020.1761242

Source DB: PubMed Journal: Mol Cell Oncol ISSN： 2372-3556

9 in total

1. AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress.

Authors: Sang-Min Jeon; Navdeep S Chandel; Nissim Hay
Journal: Nature Date: 2012-05-09 Impact factor: 49.962

Review 2. An overview of lipid peroxidation with emphasis in outer segments of photoreceptors and the chemiluminescence assay.

Authors: Angel Catalá
Journal: Int J Biochem Cell Biol Date: 2006-03-02 Impact factor: 5.085

Review 3. AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance.

Authors: Daniel Garcia; Reuben J Shaw
Journal: Mol Cell Date: 2017-06-15 Impact factor: 17.970

4. ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition.

Authors: Sebastian Doll; Bettina Proneth; Yulia Y Tyurina; Elena Panzilius; Sho Kobayashi; Irina Ingold; Martin Irmler; Johannes Beckers; Michaela Aichler; Axel Walch; Holger Prokisch; Dietrich Trümbach; Gaowei Mao; Feng Qu; Hulya Bayir; Joachim Füllekrug; Christina H Scheel; Wolfgang Wurst; Joel A Schick; Valerian E Kagan; José Pedro Friedmann Angeli; Marcus Conrad
Journal: Nat Chem Biol Date: 2016-11-14 Impact factor: 15.040

5. Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis.

Authors: Valerian E Kagan; Gaowei Mao; Feng Qu; Jose Pedro Friedmann Angeli; Sebastian Doll; Claudette St Croix; Haider Hussain Dar; Bing Liu; Vladimir A Tyurin; Vladimir B Ritov; Alexandr A Kapralov; Andrew A Amoscato; Jianfei Jiang; Tamil Anthonymuthu; Dariush Mohammadyani; Qin Yang; Bettina Proneth; Judith Klein-Seetharaman; Simon Watkins; Ivet Bahar; Joel Greenberger; Rama K Mallampalli; Brent R Stockwell; Yulia Y Tyurina; Marcus Conrad; Hülya Bayır
Journal: Nat Chem Biol Date: 2016-11-14 Impact factor: 15.040

6. Regulation of ferroptotic cancer cell death by GPX4.

Authors: Wan Seok Yang; Rohitha SriRamaratnam; Matthew E Welsch; Kenichi Shimada; Rachid Skouta; Vasanthi S Viswanathan; Jaime H Cheah; Paul A Clemons; Alykhan F Shamji; Clary B Clish; Lewis M Brown; Albert W Girotti; Virginia W Cornish; Stuart L Schreiber; Brent R Stockwell
Journal: Cell Date: 2014-01-16 Impact factor: 41.582

Review 7. Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease.

Authors: Brent R Stockwell; José Pedro Friedmann Angeli; Hülya Bayir; Ashley I Bush; Marcus Conrad; Scott J Dixon; Simone Fulda; Sergio Gascón; Stavroula K Hatzios; Valerian E Kagan; Kay Noel; Xuejun Jiang; Andreas Linkermann; Maureen E Murphy; Michael Overholtzer; Atsushi Oyagi; Gabriela C Pagnussat; Jason Park; Qitao Ran; Craig S Rosenfeld; Konstantin Salnikow; Daolin Tang; Frank M Torti; Suzy V Torti; Shinya Toyokuni; K A Woerpel; Donna D Zhang
Journal: Cell Date: 2017-10-05 Impact factor: 41.582

8. Energy-stress-mediated AMPK activation inhibits ferroptosis.

Authors: Hyemin Lee; Fereshteh Zandkarimi; Yilei Zhang; Jitendra Kumar Meena; Jongchan Kim; Li Zhuang; Siddhartha Tyagi; Li Ma; Thomas F Westbrook; Gregory R Steinberg; Daisuke Nakada; Brent R Stockwell; Boyi Gan
Journal: Nat Cell Biol Date: 2020-02-06 Impact factor: 28.824

9. BAP1 links metabolic regulation of ferroptosis to tumour suppression.

Authors: Yilei Zhang; Jiejun Shi; Xiaoguang Liu; Li Feng; Zihua Gong; Pranavi Koppula; Kapil Sirohi; Xu Li; Yongkun Wei; Hyemin Lee; Li Zhuang; Gang Chen; Zhen-Dong Xiao; Mien-Chie Hung; Junjie Chen; Peng Huang; Wei Li; Boyi Gan
Journal: Nat Cell Biol Date: 2018-09-10 Impact factor: 28.824

9 in total

10 in total

10. TQFL12, a novel synthetic derivative of TQ, inhibits triple-negative breast cancer metastasis and invasion through activating AMPK/ACC pathway.

Authors: Chunli Wei; Hui Zou; Ting Xiao; Xiaoyan Liu; Qianqian Wang; Jingliang Cheng; Shangyi Fu; Jiangzhou Peng; Xin Xie; Junjiang Fu
Journal: J Cell Mol Med Date: 2021-10-05 Impact factor: 5.310

10 in total

Energy stress inhibits ferroptosis via AMPK.

1. AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress.

Review 2. An overview of lipid peroxidation with emphasis in outer segments of photoreceptors and the chemiluminescence assay.

Review 3. AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance.

4. ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition.

5. Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis.

6. Regulation of ferroptotic cancer cell death by GPX4.

Review 7. Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease.

8. Energy-stress-mediated AMPK activation inhibits ferroptosis.

9. BAP1 links metabolic regulation of ferroptosis to tumour suppression.

Review 1. Protection by metformin against severe Covid-19: An in-depth mechanistic analysis.

Review 2. Novel Insights in the Regulatory Mechanisms of Ferroptosis in Hepatocellular Carcinoma.

Review 3. The Cross-Link between Ferroptosis and Kidney Diseases.

Review 4. Targeting ferroptosis as a vulnerability in cancer.

Review 5. Ferroptosis and Its Potential Role in Lung Cancer: Updated Evidence from Pathogenesis to Therapy.

Review 6. Emerging Roles of Energy Metabolism in Ferroptosis Regulation of Tumor Cells.

Review 7. Ferroptosis: Redox Imbalance and Hematological Tumorigenesis.

Review 8. Non-coding RNAs and ferroptosis: potential implications for cancer therapy.

Review 9. The potential interplay between G-quadruplex and p53: their roles in regulation of ferroptosis in cancer.

10. TQFL12, a novel synthetic derivative of TQ, inhibits triple-negative breast cancer metastasis and invasion through activating AMPK/ACC pathway.