Literature DB >> 32944620

In vivo CRISPR screens reveal potent driver mutations in head and neck cancers.

Sampath Kumar Loganathan1, Daniel Schramek1,2.   

Abstract

We have recently tested the transforming potential of 484 'long-tail' genes, which are recurrently albeit infrequently mutated in head and neck cancers (HNSCC). We identified 15 novel tumor suppressors and our top hits converge on regulating the NOTCH signaling pathway. Therapeutic approaches activating NOTCH signaling could be a promising strategy to treat two-thirds of human HNSCC patients.
© 2020 Taylor & Francis Group, LLC.

Entities:  

Keywords:  HNSCC; Notch; in vivo CRISPR; long-tail genes; mouse models of cancer

Year:  2020        PMID： 32944620      PMCID： PMC7469622          DOI： 10.1080/23723556.2020.1758541

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  6 in total

1.  Rapid functional dissection of genetic networks via tissue-specific transduction and RNAi in mouse embryos.

Authors:  Slobodan Beronja; Geulah Livshits; Scott Williams; Elaine Fuchs
Journal:  Nat Med       Date:  2010-06-06       Impact factor: 53.440

2.  A New Model T on the Horizon?

Authors:  Xiaohong Helena Yang
Journal:  Cell       Date:  2017-09-21       Impact factor: 41.582

Review 3.  The molecular landscape of head and neck cancer.

Authors:  C René Leemans; Peter J F Snijders; Ruud H Brakenhoff
Journal:  Nat Rev Cancer       Date:  2018-03-02       Impact factor: 60.716

4.  Synthetic lethality in ATM-deficient RAD50-mutant tumors underlies outlier response to cancer therapy.

Authors:  Hikmat Al-Ahmadie; Gopa Iyer; Marcel Hohl; Saurabh Asthana; Akiko Inagaki; Nikolaus Schultz; Aphrothiti J Hanrahan; Sasinya N Scott; A Rose Brannon; Gregory C McDermott; Mono Pirun; Irina Ostrovnaya; Philip Kim; Nicholas D Socci; Agnes Viale; Gary K Schwartz; Victor Reuter; Bernard H Bochner; Jonathan E Rosenberg; Dean F Bajorin; Michael F Berger; John H J Petrini; David B Solit; Barry S Taylor
Journal:  Cancer Discov       Date:  2014-06-16       Impact factor: 39.397

5.  Pan-cancer analysis of whole genomes.

Authors: 
Journal:  Nature       Date:  2020-02-05       Impact factor: 49.962

6.  RNAi screens in mice identify physiological regulators of oncogenic growth.

Authors:  Slobodan Beronja; Peter Janki; Evan Heller; Wen-Hui Lien; Brice E Keyes; Naoki Oshimori; Elaine Fuchs
Journal:  Nature       Date:  2013-08-14       Impact factor: 49.962
  6 in total

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