Literature DB >> 32943210

Which Way Do We Go? Complex Interactions in Atopic Dermatitis Pathogenesis.

Garrett J Patrick1, Nathan K Archer1, Lloyd S Miller2.   

Abstract

Atopic dermatitis (AD) is a common, chronic, inflammatory skin condition characterized by recurrent and pruritic skin eruptions. Multiple factors contribute to the pathogenesis of AD, including skin barrier dysfunction, microbial dysbiosis, and immune dysregulation. Interactions among these factors form a complex, multidirectional network that can reinforce atopic skin disease but can also be ameliorated by targeted therapies. This review summarizes the complex interactions among contributing factors in AD and the implications on disease development and therapeutic interventions.
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

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Year:  2020        PMID： 32943210      PMCID： PMC7855294          DOI： 10.1016/j.jid.2020.07.006

Source DB:  PubMed          Journal:  J Invest Dermatol        ISSN： 0022-202X            Impact factor:   8.551


  143 in total

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Authors:  Ehrhardt Proksch; Regina Fölster-Holst; Jens-Michael Jensen
Journal:  J Dermatol Sci       Date:  2006-08-02       Impact factor: 4.563

2.  A tryptophan metabolite of the skin microbiota attenuates inflammation in patients with atopic dermatitis through the aryl hydrocarbon receptor.

Authors:  Jinlei Yu; Yang Luo; Zhenlai Zhu; Yufeng Zhou; Licheng Sun; Jixin Gao; Jinlv Sun; Gang Wang; Xu Yao; Wei Li
Journal:  J Allergy Clin Immunol       Date:  2018-12-20       Impact factor: 10.793

3.  Transplantation of human skin microbiota in models of atopic dermatitis.

Authors:  Ian A Myles; Kelli W Williams; Jensen D Reckhow; Momodou L Jammeh; Nathan B Pincus; Inka Sastalla; Danial Saleem; Kelly D Stone; Sandip K Datta
Journal:  JCI Insight       Date:  2016-07-07

Review 4.  The human skin microbiome.

Authors:  Allyson L Byrd; Yasmine Belkaid; Julia A Segre
Journal:  Nat Rev Microbiol       Date:  2018-01-15       Impact factor: 60.633

5.  Persistent skin colonization with Staphylococcus aureus in atopic dermatitis: relationship to clinical and immunological parameters.

Authors:  T J Guzik; M Bzowska; A Kasprowicz; G Czerniawska-Mysik; K Wójcik; D Szmyd; T Adamek-Guzik; J Pryjma
Journal:  Clin Exp Allergy       Date:  2005-04       Impact factor: 5.018

6.  IL-4 and IL-13 negatively regulate TNF-alpha- and IFN-gamma-induced beta-defensin expression through STAT-6, suppressor of cytokine signaling (SOCS)-1, and SOCS-3.

Authors:  Cristina Albanesi; Heather R Fairchild; Stefania Madonna; Claudia Scarponi; Ornella De Pità; Donald Y M Leung; Michael D Howell
Journal:  J Immunol       Date:  2007-07-15       Impact factor: 5.422

Review 7.  The effect of environmental humidity and temperature on skin barrier function and dermatitis.

Authors:  K A Engebretsen; J D Johansen; S Kezic; A Linneberg; J P Thyssen
Journal:  J Eur Acad Dermatol Venereol       Date:  2015-10-08       Impact factor: 6.166

8.  The Th2 cytokine, interleukin-4, abrogates the cohesion of normal stratum corneum in mice: implications for pathogenesis of atopic dermatitis.

Authors:  Yutaka Hatano; Yasuko Adachi; Peter M Elias; Debra Crumrine; Takashi Sakai; Rieko Kurahashi; Kazumoto Katagiri; Sakuhei Fujiwara
Journal:  Exp Dermatol       Date:  2012-11-22       Impact factor: 3.960

9.  Efficacy and safety of fezakinumab (an IL-22 monoclonal antibody) in adults with moderate-to-severe atopic dermatitis inadequately controlled by conventional treatments: A randomized, double-blind, phase 2a trial.

Authors:  Emma Guttman-Yassky; Patrick M Brunner; Avidan U Neumann; Saakshi Khattri; Ana B Pavel; Kunal Malik; Giselle K Singer; Danielle Baum; Patricia Gilleaudeau; Mary Sullivan-Whalen; Sharon Rose; Shelbi Jim On; Xuan Li; Judilyn Fuentes-Duculan; Yeriel Estrada; Sandra Garcet; Claudia Traidl-Hoffmann; James G Krueger; Mark G Lebwohl
Journal:  J Am Acad Dermatol       Date:  2018-01-17       Impact factor: 11.527

10.  Microbiome dynamics of human epidermis following skin barrier disruption.

Authors:  Patrick L J M Zeeuwen; Jos Boekhorst; Ellen H van den Bogaard; Heleen D de Koning; Peter M C van de Kerkhof; Delphine M Saulnier; Iris I van Swam; Sacha A F T van Hijum; Michiel Kleerebezem; Joost Schalkwijk; Harro M Timmerman
Journal:  Genome Biol       Date:  2012-11-15       Impact factor: 13.583
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  10 in total

1.  An Atopic Dermatitis-Like Mouse Model by Alternate Epicutaneous Application of Dinitrofluorobenzene and an Extract of Dermatophagoides Farinae.

Authors:  Shujing Feng; Wengying Liu; Sisi Deng; Guoxuan Song; Jie Zhou; Zhengni Zheng; Zhiqiang Song
Journal:  Front Med (Lausanne)       Date:  2022-06-15

2.  Comparison of Gut Microbiota Between Infants with Atopic Dermatitis and Healthy Controls in Guangzhou, China.

Authors:  Li Yu; Yu-Hong Deng; Yuan-Hui Huang; Hai-Jin Ke; Yong Guo; Jie-Ling Wu
Journal:  J Asthma Allergy       Date:  2021-05-10

3.  Murine Models for Staphylococcal Infection.

Authors:  Nathan Klopfenstein; James E Cassat; Andrew Monteith; Anderson Miller; Sydney Drury; Eric Skaar; C Henrique Serezani
Journal:  Curr Protoc       Date:  2021-03

Review 4.  Atopic Dermatitis as a Multifactorial Skin Disorder. Can the Analysis of Pathophysiological Targets Represent the Winning Therapeutic Strategy?

Authors:  Irene Magnifico; Giulio Petronio Petronio; Noemi Venditti; Marco Alfio Cutuli; Laura Pietrangelo; Franca Vergalito; Katia Mangano; Davide Zella; Roberto Di Marco
Journal:  Pharmaceuticals (Basel)       Date:  2020-11-22

Review 5.  Five Functional Aspects of the Epidermal Barrier.

Authors:  Alain Lefèvre-Utile; Camille Braun; Marek Haftek; François Aubin
Journal:  Int J Mol Sci       Date:  2021-10-28       Impact factor: 5.923

Review 6.  Post-Translational Modifications in Atopic Dermatitis: Current Research and Clinical Relevance.

Authors:  Xin Ma; Yi Ru; Ying Luo; Le Kuai; Qi-Long Chen; Yun Bai; Ye-Qiang Liu; Jia Chen; Yue Luo; Jian-Kun Song; Mi Zhou; Bin Li
Journal:  Front Cell Dev Biol       Date:  2022-07-07

7.  Herpes Simplex Virus 1 Can Bypass Impaired Epidermal Barriers upon Ex Vivo Infection of Skin from Atopic Dermatitis Patients.

Authors:  Maureen Möckel; Nydia C De La Cruz; Matthias Rübsam; Lisa Wirtz; Iliana Tantcheva-Poor; Wolfram Malter; Max Zinser; Thomas Bieber; Dagmar Knebel-Mörsdorf
Journal:  J Virol       Date:  2022-08-15       Impact factor: 6.549

8.  Plasma Exosomes from Children with Atopic Dermatitis May Promote Apoptosis of Keratinocytes and Secretion of Inflammatory Factors in vitro.

Authors:  Teng Zhu; Jing Sun; Lin Ma; Jing Tian
Journal:  Clin Cosmet Investig Dermatol       Date:  2022-09-14

9.  Moderate-to-severe atopic dermatitis in adolescents treated with dupilumab: A multicentre Italian real-world experience.

Authors:  L Stingeni; L Bianchi; E Antonelli; E S Caroppo; S M Ferrucci; M Ortoncelli; G Fabbrocini; E Nettis; D Schena; M Napolitano; M Gola; L Bonzano; M Rossi; A Belloni Fortina; A Balato; K Peris; C Foti; F Guarneri; M Romanelli; C Patruno; P Savoia; M C Fargnoli; F Russo; E Errichetti; T Bianchelli; L Bianchi; G Pellacani; C Feliciani; A Offidani; M Corazza; G Micali; N Milanesi; G Malara; A Chiricozzi; M Tramontana; K Hansel
Journal:  J Eur Acad Dermatol Venereol       Date:  2022-04-22       Impact factor: 9.228

Review 10.  Role of Aryl Hydrocarbon Receptor Activation in Inflammatory Chronic Skin Diseases.

Authors:  Maddalena Napolitano; Gabriella Fabbrocini; Fabrizio Martora; Vincenzo Picone; Paola Morelli; Cataldo Patruno
Journal:  Cells       Date:  2021-12-16       Impact factor: 6.600
  10 in total

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