High-sensitivity detection of dopamine by biomimetic nanofluidic diodes derivatized with poly(3-aminobenzylamine).

During the last few years, much scientific effort has been devoted to the control of ionic transport properties of solid state nanochannels and the rational integration of chemical systems to induce changes in the ionic transport by interaction with selected target molecules for (bio)sensing purposes. In this work, we present the construction and functional evaluation of a highly sensitive dopamine-responsive iontronic device by functionalization of bullet-shaped track-etched single nanochannels in PET membranes with poly(3-aminobenzylamine) (PABA). The variety of basic groups in this amino-appended polyaniline derivative allows programming of the ion selectivity of the channel by setting the pH conditions. On the other hand, the amino-pendant groups of PABA become suitable binding sites for the selective chemical reaction with dopamine, leading to a change in the nanochannel surface charge. Thus, the exposure of the PABA-modified nanochannel to dopamine solutions selectively produces changes in the iontronic response. By rationally selecting the conditions for both the dopamine binding step and the iontronic reading, we obtained a correlation between the rectification efficiency and dopamine concentration down to the nanomolar range, which was also successfully interpreted in terms of a simple binding model.