Marisa G Stahl1, Fran Dong2, Molly M Lamb3, Kathleen C Waugh2, Iman Taki2, Ketil Størdal4,5, Lars C Stene4, Marian J Rewers2, Edwin Liu1, Jill M Norris3, Karl Mårild6,7. 1. Digestive Health Institute, Department of Pediatrics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. 2. Barbara Davis Center for Diabetes, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. 3. Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. 4. Division of Mental and Physical Health, Norwegian Institute of Public Health, Oslo, Norway. 5. Department of Pediatrics, Østfold Hospital Trust, Grålum, Norway. 6. Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg, Sweden. 7. Department of Pediatric Gastroenterology, Queen Silvia Children's Hospital, Gothenburg, Sweden.
Abstract
OBJECTIVES: To determine the association between childhood growth prior to the development of celiac disease (CD) and CD autoimmunity (CDA) identified by periodic serological screening. STUDY DESIGN: The Diabetes Autoimmunity Study in the Young cohort includes 1979 genetically at-risk children from Denver, Colorado, with annual growth measurements from age nine months until ten years. Between 1993 and February 2019, 120 children developed CDA defined by persistent positive tissue transglutaminase autoantibodies (TGA); among these, 71 met our criteria for CD based on histopathological findings or high TGA levels. Age- and sex-specific z-scores of weight, body mass index (BMI), and height prior to seroconversion were derived using US reference charts as standards. Joint modeling of serial growth measurements was used to estimate adjusted hazard ratios (aHRs) accounting for celiac-associated human leukocyte antigens, early-life feeding practices, and socio-demographics. RESULTS: In the first 10 years of life, there were no significant associations between the child's current weight, BMI and height and the risk of screening-detected CDA or CD, neither was the weight nor BMI velocity associated with CDA or CD as identified by screening (all aHRs approximated 1). Increased height velocity was associated with later CD, but not CDA, development (aHR per 0.01-z score/year, 1.28; 95% confidence interval [CI] 1.18-1.38 and 1.03; 0.97-1.09, respectively). CONCLUSIONS: In the first 10 years of life, from prospectively collected serial growth measurements, we found no evidence of impaired childhood growth before CD and CDA development as identified through early and periodic screening.
OBJECTIVES: To determine the association between childhood growth prior to the development of celiac disease (CD) and CD autoimmunity (CDA) identified by periodic serological screening. STUDY DESIGN: The Diabetes Autoimmunity Study in the Young cohort includes 1979 genetically at-risk children from Denver, Colorado, with annual growth measurements from age nine months until ten years. Between 1993 and February 2019, 120 children developed CDA defined by persistent positive tissue transglutaminase autoantibodies (TGA); among these, 71 met our criteria for CD based on histopathological findings or high TGA levels. Age- and sex-specific z-scores of weight, body mass index (BMI), and height prior to seroconversion were derived using US reference charts as standards. Joint modeling of serial growth measurements was used to estimate adjusted hazard ratios (aHRs) accounting for celiac-associated human leukocyte antigens, early-life feeding practices, and socio-demographics. RESULTS: In the first 10 years of life, there were no significant associations between the child's current weight, BMI and height and the risk of screening-detected CDA or CD, neither was the weight nor BMI velocity associated with CDA or CD as identified by screening (all aHRs approximated 1). Increased height velocity was associated with later CD, but not CDA, development (aHR per 0.01-z score/year, 1.28; 95% confidence interval [CI] 1.18-1.38 and 1.03; 0.97-1.09, respectively). CONCLUSIONS: In the first 10 years of life, from prospectively collected serial growth measurements, we found no evidence of impaired childhood growth before CD and CDA development as identified through early and periodic screening.
Entities:
Keywords:
Height; anthropometric measures; body mass index; weight
Authors: Anna R Rasmussen; Christine Wohlfahrt-Veje; Katrine Tefre de Renzy-Martin; Casper P Hagen; Jeanette Tinggaard; Annette Mouritsen; Mikkel G Mieritz; Katharina M Main Journal: Pediatrics Date: 2014-12-22 Impact factor: 7.124
Authors: Marcella Li; Liping Yu; Claudio Tiberti; Margherita Bonamico; Iman Taki; Dongmei Miao; Joseph A Murray; Marian J Rewers; Edward J Hoffenberg; Daniel Agardh; Patricia Mueller; Martin Stern; Ezio Bonifacio; Edwin Liu Journal: Am J Gastroenterol Date: 2009-01 Impact factor: 10.864
Authors: Michelle A E Jansen; Jessica C Kiefte-de Jong; Romy Gaillard; Johanna C Escher; Albert Hofman; Vincent W V Jaddoe; Herbert Hooijkaas; Henriette A Moll Journal: Clin Gastroenterol Hepatol Date: 2014-09-22 Impact factor: 11.382
Authors: Edwin Liu; Hye-Seung Lee; Carin A Aronsson; William A Hagopian; Sibylle Koletzko; Marian J Rewers; George S Eisenbarth; Polly J Bingley; Ezio Bonifacio; Ville Simell; Daniel Agardh Journal: N Engl J Med Date: 2014-07-03 Impact factor: 176.079
Authors: Maria van der Pals; Anna Myléus; Fredrik Norström; Solveig Hammarroth; Lotta Högberg; Anna Rosén; Anneli Ivarsson; Annelie Carlsson Journal: BMC Pediatr Date: 2014-06-30 Impact factor: 2.125
Authors: A Sayers; J Heron; Adac Smith; C Macdonald-Wallis; M S Gilthorpe; F Steele; K Tilling Journal: Stat Methods Med Res Date: 2016-07-11 Impact factor: 3.021