| Literature DB >> 32940695 |
James L Dorling1, Stephan van Vliet1, Kim M Huffman2, William E Kraus2, Manjushri Bhapkar2, Carl F Pieper2, Tiffany Stewart1, Sai Krupa Das3, Susan B Racette4, Susan B Roberts3, Eric Ravussin1, Leanne M Redman1, Corby K Martin1.
Abstract
Caloric restriction (CR) is a strategy that attenuates aging in multiple nonhuman species. The Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE) trials are part of a research program aiming to test the effects of CR on aging and longevity biomarkers in humans. Building on CALERIE phase 1, CALERIE phase 2 (CALERIE 2) was the largest study to date to assess sustained CR in healthy humans without obesity. In a 24-month randomized controlled trial comprising 218 participants at baseline, CALERIE 2 showed that moderate CR, 11.9% on average, induced improvements in aging-related biomarkers without adversely affecting psychological or behavioral outcomes. The objectives of this report are to summarize and review the highlights of CALERIE 2 and report previously unpublished results on eating disorder symptoms and cognitive function. This article specifically summarizes the physiological, psychological, aging, behavioral, and safety results of the trial. Also provided are research directions beyond CALERIE 2 that highlight important opportunities to investigate the role of CR in aging, longevity, and health span in humans.Entities:
Keywords: zzm321990 agingzzm321990 ; zzm321990 longevityzzm321990 ; zzm321990 metabolismzzm321990 ; zzm321990 quality of lifezzm321990 ; zzm321990 randomized controlled trialzzm321990
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Year: 2021 PMID： 32940695 PMCID： PMC7727025 DOI： 10.1093/nutrit/nuaa085
Source DB: PubMed Journal: Nutr Rev ISSN： 0029-6643 Impact factor: 7.110