Hao Fu1, Shaoping Nie1, Ping Luo1, Yang Ruan2, Zichuan Zhang3, Huangtai Miao1, Xin Li3, Songnan Wen3, Rong Bai3,4. 1. Emergency & Critical Care Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, China. 2. Department of Cardiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. 3. Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China. 4. Texas Cardiac Arrhythmia Institute at St. David's Medical Center, Austin TX 78706, USA.
Abstract
Aim: This study sought to investigate the relationship between galectin-3 (Gal-3), myocardial fibrosis (MF) and outcomes in acute heart failure. Materials & methods: The single-nucleotide polymorphisms (SNPs) of LGALS3 at rs4644 and rs4652, plasma Gal-3 level, MF and major adverse events (MAEs) were obtained. Results: There was no significant difference in MAEs when categorizing patients by the LGALS3 SNPs at rs4644 and rs4652. The circulating Gal-3 was related to the degree of MF (p < 0.001). Plasma Gal-3 level and MF can predict an increased risk of MAEs (p < 0.001, p = 0.023, respectively). Conclusion: Not the SNPs of LGALS3 but Gal-3 and MF can predict MAEs in acute heart failure at 1 year of follow-up.
Aim: This study sought to investigate the relationship between galectin-3 (Gal-3), myocardial fibrosis (MF) and outcomes in acute heart failure. Materials & methods: The single-nucleotide polymorphisms (SNPs) of LGALS3 at rs4644 and rs4652, plasma Gal-3 level, MF and major adverse events (MAEs) were obtained. Results: There was no significant difference in MAEs when categorizing patients by the LGALS3 SNPs at rs4644 and rs4652. The circulating Gal-3 was related to the degree of MF (p < 0.001). Plasma Gal-3 level and MF can predict an increased risk of MAEs (p < 0.001, p = 0.023, respectively). Conclusion: Not the SNPs of LGALS3 but Gal-3 and MF can predict MAEs in acute heart failure at 1 year of follow-up.
Authors: Volker H Schmitt; Jürgen H Prochaska; Annegret S Föll; Andreas Schulz; Karsten Keller; Omar Hahad; Thomas Koeck; Sven-Oliver Tröbs; Steffen Rapp; Manfred Beutel; Norbert Pfeiffer; Konstantin Strauch; Karl J Lackner; Thomas Münzel; Philipp S Wild Journal: Sci Rep Date: 2021-09-24 Impact factor: 4.379