Literature DB >> 3293998

Expression of the FGF-related proto-oncogene int-2 during gastrulation and neurulation in the mouse.

D G Wilkinson1, G Peters, C Dickson, A P McMahon.   

Abstract

The proto-oncogene int-2 has been implicated in the formation of mouse mammary-tumour-virus-induced mammary tumours. Analysis of the predicted coding sequence indicates that int-2 is a member of the fibroblast growth factor family. Previous studies using Northern blot analysis suggested that normal expression of int-2 may be confined to extra-embryonic endoderm lineages of embryonic stages of mouse development. We have used in situ hybridization and Northern blot analysis to examine directly int-2 expression in embryo stem cells and in the developing embryo from early gastrulation to midsomite stages. Complex patterns of accumulation of int-2 RNA were observed in embryonic and extra-embryonic tissues. The data suggest multiple roles for int-2 in development which may include migration of early mesoderm cells and induction of the otocyst.

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Year:  1988        PMID： 3293998      PMCID： PMC454374          DOI： 10.1002/j.1460-2075.1988.tb02864.x

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  33 in total

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Authors:  M Dziadek
Journal:  J Embryol Exp Morphol       Date:  1978-08

2.  An autoradiographic analysis of tissue potency in different regions of the embryonic ectoderm during gastrulation in the mouse.

Authors:  R S Beddington
Journal:  J Embryol Exp Morphol       Date:  1982-06

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Authors:  P P Tam; S Meier; A G Jacobson
Journal:  Differentiation       Date:  1982       Impact factor: 3.880

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Authors:  M H Snow
Journal:  J Embryol Exp Morphol       Date:  1981-10

5.  Establishment in culture of pluripotential cells from mouse embryos.

Authors:  M J Evans; M H Kaufman
Journal:  Nature       Date:  1981-07-09       Impact factor: 49.962

6.  Preservation of hamster oocytes to assay the fertilizing capacity of human spermatozoa.

Authors:  P Quinn; C Barros; D G Whittingham
Journal:  J Reprod Fertil       Date:  1982-09

7.  The establishment of a somitomeric pattern in the mesoderm of the gastrulating mouse embryo.

Authors:  P P Tam; S Meier
Journal:  Am J Anat       Date:  1982-07

8.  Mouse actin messenger RNAs. Construction and characterization of a recombinant plasmid molecule containing a complementary DNA transcript of mouse alpha-actin mRNA.

Authors:  A J Minty; M Caravatti; B Robert; A Cohen; P Daubas; A Weydert; F Gros; M E Buckingham
Journal:  J Biol Chem       Date:  1981-01-25       Impact factor: 5.157

9.  The evolution of alpha-fetoprotein and albumin. II. The structures of the alpha-fetoprotein and albumin genes in the mouse.

Authors:  D Kioussis; F Eiferman; P van de Rijn; M B Gorin; R S Ingram; S M Tilghman
Journal:  J Biol Chem       Date:  1981-02-25       Impact factor: 5.157

10.  Tumorigenesis by mouse mammary tumor virus: evidence for a common region for provirus integration in mammary tumors.

Authors:  G Peters; S Brookes; R Smith; C Dickson
Journal:  Cell       Date:  1983-06       Impact factor: 41.582
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  60 in total

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Authors:  A Streit
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Authors:  Akira Murakami; Sanami Ishida; Clive Dickson
Journal:  Nucleic Acids Res       Date:  2002-02-15       Impact factor: 16.971

3.  Fgfr1 regulates patterning of the pharyngeal region.

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Authors:  Jeffery R Barrow; Kirk R Thomas; Oreda Boussadia-Zahui; Robert Moore; Rolf Kemler; Mario R Capecchi; Andrew P McMahon
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5.  Heparin-binding growth factors and their receptors.

Authors:  B B Olwin
Journal:  Cytotechnology       Date:  1989-12       Impact factor: 2.058

6.  Introduction of a lacZ reporter gene into the mouse int-2 locus by homologous recombination.

Authors:  S L Mansour; K R Thomas; C X Deng; M R Capecchi
Journal:  Proc Natl Acad Sci U S A       Date:  1990-10       Impact factor: 11.205

7.  Epigenetic Interactions and Gene Expression in Peri-Implantation Mouse Embryo Development.

Authors:  Jean J Latimer; Roger A Pedersen
Journal:  Mod Cell Biol       Date:  1993

8.  Biphasic role for Wnt/beta-catenin signaling in cardiac specification in zebrafish and embryonic stem cells.

Authors:  Shuichi Ueno; Gilbert Weidinger; Tomoaki Osugi; Aimee D Kohn; Jonathan L Golob; Lil Pabon; Hans Reinecke; Randall T Moon; Charles E Murry
Journal:  Proc Natl Acad Sci U S A       Date:  2007-05-23       Impact factor: 11.205

9.  FGF8 initiates inner ear induction in chick and mouse.

Authors:  Raj K Ladher; Tracy J Wright; Anne M Moon; Suzanne L Mansour; Gary C Schoenwolf
Journal:  Genes Dev       Date:  2005-03-01       Impact factor: 11.361

10.  Binary system for regulating transgene expression in mice: targeting int-2 gene expression with yeast GAL4/UAS control elements.

Authors:  D M Ornitz; R W Moreadith; P Leder
Journal:  Proc Natl Acad Sci U S A       Date:  1991-02-01       Impact factor: 11.205
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