Mehdi Martani1,2,3, Mohamed Kheireddine Bourahli1,2,3, Mohamed Bougrida1,2,3, Helmi Ben Saad4,5,6. 1. Département de Physiologie, Faculté de Médecine de Constantine, Université Constantine 3 , Constantine, Algeria. 2. Service de Physiologie Clinique et Explorations Fonctionnelles, CHU Dr Ben Badis Constantine , Constantine, Algeria. 3. Laboratoire de Recherche des Maladies Métaboliques, Université Constantine 3 , Constantine, Algeria. 4. Laboratory of Physiology and Functional Explorations, Farhat HACHED Hospital , Sousse, Tunisia. 5. Heart Failure (LR12SP09) Research Laboratory, Farhat HACHED Hospital , Sousse, Tunisia. 6. Université de Sousse, Faculté de Médecine de Sousse, Laboratoire de Physiologie , Sousse, Tunisie.
Abstract
OBJECTIVES: In obstructive sleep apnea (OSA) patients, the frequencies of the different ventilatory defects are unknown and the studies examining their plethysmographic profiles and/or pulmonary function test data have contradictory results. The main aim of this prospective study was to establish the plethysmographic profile of severe OSA patients treated with continuous positive airway pressure (CPAP). METHODS: 100 (33 females) clinically consecutive stable patients with severe OSA treated with CPAP were included. Anthropometric, polysomnographic, and pulmonary function test data were collected. The following definitions were applied: large airways obstructive ventilatory defect (LAOVD): (FEV1/SVC or FEV1/FVC < lower limit of normal (LLN), small airways obstructive ventilatory defect (SAOVD): (FEV1/FVC and FVC) > LLN and maximal mid-expiratory flow (MMEF) < LLN, restrictive ventilatory defect (RVD): total lung capacity (TLC) < LLN, lung-hyperinflation: residual volume > upper limit of-normal, and nonspecific ventilatory defect (NSVD): (FVC and FEV1) < LLN and TLC > LLN and (FEV1/SVC or FEV1/FVC) > LLN. RESULTS: The plethysmographic profile of OSA patients included RVD (73%), SAOVD (50%), LAOVD (16%), mixed-VD (11%), lung-hyperinflation (11%), and NSVD (2%). CONCLUSION: The plethysmographic profile of OSA patients was dominated by the presence of an RVD.
OBJECTIVES: In obstructive sleep apnea (OSA) patients, the frequencies of the different ventilatory defects are unknown and the studies examining their plethysmographic profiles and/or pulmonary function test data have contradictory results. The main aim of this prospective study was to establish the plethysmographic profile of severe OSA patients treated with continuous positive airway pressure (CPAP). METHODS: 100 (33 females) clinically consecutive stable patients with severe OSA treated with CPAP were included. Anthropometric, polysomnographic, and pulmonary function test data were collected. The following definitions were applied: large airways obstructive ventilatory defect (LAOVD): (FEV1/SVC or FEV1/FVC < lower limit of normal (LLN), small airways obstructive ventilatory defect (SAOVD): (FEV1/FVC and FVC) > LLN and maximal mid-expiratory flow (MMEF) < LLN, restrictive ventilatory defect (RVD): total lung capacity (TLC) < LLN, lung-hyperinflation: residual volume > upper limit of-normal, and nonspecific ventilatory defect (NSVD): (FVC and FEV1) < LLN and TLC > LLN and (FEV1/SVC or FEV1/FVC) > LLN. RESULTS: The plethysmographic profile of OSA patients included RVD (73%), SAOVD (50%), LAOVD (16%), mixed-VD (11%), lung-hyperinflation (11%), and NSVD (2%). CONCLUSION: The plethysmographic profile of OSA patients was dominated by the presence of an RVD.
Entities:
Keywords:
Obstructive sleep apnea; lung function testing; obesity; plethysmography