| Literature DB >> 32936732 |
Idris Nasir Abdullahi1, Anthony Uchenna Emeribe2, Hafeez Aderinsayo Adekola3, Sharafudeen Dahiru Abubakar1, Amos Dangana4, Halima Ali Shuwa5, Sunday Theophilus Nwoba6, Jelili Olaide Mustapha7, Muyideen Titilope Haruna8, Kafayat Adepeju Olowookere9, Olawale Sunday Animasaun10, Charles Egede Ugwu11, Solomon Oloche Onoja12, Abdullahi Sani Gadama13, Musa Mohammed14, Isa Muhammad Daneji13, Dele Ohinoyi Amadu15, Peter Elisha Ghamba16, Nkechi Blessing Onukegbe17, Muhammad Sagir Shehu18, Chiladi Isomah19, Adamu Babayo13, Abdurrahman El-Fulaty Ahmad1.
Abstract
The incidence and case-fatality rates (CFRs) of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, the etiological agent for Coronavirus Disease 2019 (COVID-19), have been rising unabated. Even though the entire world has been implementing infection prevention and control measures, the pandemic continues to spread. It has been widely accepted that preventive vaccination strategies are the public health measures for countering this pandemic. This study critically reviews the latest scientific advancement in genomics, replication pattern, pathogenesis, and immunopathology of SARS-CoV-2 infection and how these concepts could be used in the development of vaccines. We also offer a detailed discussion on the anticipated potency, efficacy, safety, and pharmaco-economic issues that are and will be associated with candidate COVID-19 vaccines.Entities:
Keywords: COVID-19; Host-virus interaction; SARS-CoV-2; Vaccine discovery
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Year: 2020 PMID： 32936732 PMCID： PMC7993231 DOI： 10.1080/21645515.2020.1812313
Source DB: PubMed Journal: Hum Vaccin Immunother ISSN： 2164-5515 Impact factor: 3.452