Luc P Brion1, Dale L Phelps2, Robert M Ward3, Tracy L Nolen4, N Mikko K Hallman5, Abhik Das6, Daniel J Zaccaro4, M Bethany Ball7, Kristi L Watterberg8, Ivan D Frantz9, C Michael Cotten10, Brenda B Poindexter11, William Oh12, Ralph A Lugo13, Krisa P Van Meurs7, T Michael O'Shea14, Kristin M Zaterka-Baxter4, Rosemary D Higgins15,16. 1. Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA. luc.brion@utsouthwestern.edu. 2. School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA. 3. Department of Pediatrics, Division of Neonatology, University of Utah School of Medicine, Salt Lake City, UT, USA. 4. Statistics and Epidemiology Unit, RTI International, Research Triangle Park, NC, USA. 5. PEDEGO Research Center, and MRC Oulu, University of Oulu, and Oulu University Hospital, Oulu, Finland. 6. Statistics and Epidemiology Unit, RTI International, Rockville, USA. 7. Department of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine and Lucile Packard Children's Hospital, Palo Alto, CA, USA. 8. Department of Pediatrics, University of New Mexico Health Sciences Center, Albuquerque, NM, USA. 9. Department of Pediatrics, Division of Newborn Medicine, Floating Hospital for Children, Tufts Medical Center, Boston, MA, USA. 10. Department of Pediatrics, Duke University, Durham, NC, USA. 11. Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA. 12. Department of Pediatrics, Women & Infants' Hospital, Brown University, Providence, RI, USA. 13. Department of Pharmacy Practice, Bill Gatton College of Pharmacy, East Tennessee State University, Johnson City, TN, USA. 14. Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, NC, USA. 15. Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA. 16. College of Health and Human Services, George Mason University, Fairfax, VA, USA.
Abstract
OBJECTIVE: To describe relationship between cord blood (representing fetal) myo-inositol concentrations and gestational age (GA) and to determine trends of blood concentrations in enterally and parenterally fed infants from birth to 70 days of age. DESIGN/ METHODS: Samples were collected in 281 fed or unfed infants born in 2005 and 2006. Myo-inositol concentrations were displayed in scatter plots and analyzed with linear regression models of natural log-transformed values. RESULTS: In 441 samples obtained from 281 infants, myo-inositol concentrations varied from nondetectable to 1494 μmol/L. Cord myo-inositol concentrations decreased an estimated 11.9% per week increase in GA. Postnatal myo-inositol concentrations decreased an estimated 14.3% per week increase in postmenstrual age (PMA) and were higher for enterally fed infants compared to unfed infants (51% increase for fed vs. unfed infants). CONCLUSIONS: Fetal myo-inositol concentrations decreased with increasing GA. Postnatal concentrations decreased with increasing PMA and were higher among enterally fed than unfed infants.
OBJECTIVE: To describe relationship between cord blood (representing fetal) myo-inositol concentrations and gestational age (GA) and to determine trends of blood concentrations in enterally and parenterally fed infants from birth to 70 days of age. DESIGN/ METHODS: Samples were collected in 281 fed or unfed infants born in 2005 and 2006. Myo-inositol concentrations were displayed in scatter plots and analyzed with linear regression models of natural log-transformed values. RESULTS: In 441 samples obtained from 281 infants, myo-inositol concentrations varied from nondetectable to 1494 μmol/L. Cord myo-inositol concentrations decreased an estimated 11.9% per week increase in GA. Postnatal myo-inositol concentrations decreased an estimated 14.3% per week increase in postmenstrual age (PMA) and were higher for enterally fed infants compared to unfed infants (51% increase for fed vs. unfed infants). CONCLUSIONS: Fetal myo-inositol concentrations decreased with increasing GA. Postnatal concentrations decreased with increasing PMA and were higher among enterally fed than unfed infants.
Authors: Valentina Brusati; Maciej Józwik; Marcin Józwik; Cecilia Teng; Cinzia Paolini; Anna Maria Marconi; Frederick C Battaglia Journal: Pediatr Res Date: 2005-10 Impact factor: 3.756
Authors: Dale L Phelps; Kristi L Watterberg; Tracy L Nolen; Carol A Cole; C Michael Cotten; William Oh; Brenda B Poindexter; Kristin M Zaterka-Baxter; Abhik Das; Conra Backstrom Lacy; Ann Marie Scorsone; Michele C Walsh; Edward F Bell; Kathleen A Kennedy; Kurt Schibler; Gregory M Sokol; Matthew M Laughon; Satyanarayana Lakshminrusimha; William E Truog; Meena Garg; Waldemar A Carlo; Abbot R Laptook; Krisa P Van Meurs; David P Carlton; Amanda Graf; Sara B DeMauro; Luc P Brion; Seetha Shankaran; Faruk H Orge; Richard J Olson; Helen Mintz-Hittner; Michael B Yang; Kathryn M Haider; David K Wallace; Mina Chung; Denise Hug; Irena Tsui; Martin S Cogen; John P Donahue; Michael Gaynon; Amy K Hutchinson; Don L Bremer; Graham Quinn; Yu-Guang He; William R Lucas; Timothy W Winter; Stephen D Kicklighter; Kartik Kumar; Patricia R Chess; Tarah T Colaizy; Anna Marie Hibbs; Namasivayam Ambalavanan; Heidi M Harmon; Elisabeth C McGowan; Rosemary D Higgins Journal: JAMA Date: 2018-10-23 Impact factor: 56.272
Authors: Dale L Phelps; Robert M Ward; Rick L Williams; Kristi L Watterberg; Abbot R Laptook; Lisa A Wrage; Tracy L Nolen; Timothy R Fennell; Richard A Ehrenkranz; Brenda B Poindexter; C Michael Cotten; Mikko K Hallman; Ivan D Frantz; Roger G Faix; Kristin M Zaterka-Baxter; Abhik Das; M Bethany Ball; T Michael O'Shea; Conra Backstrom Lacy; Michele C Walsh; Seetha Shankaran; Pablo J Sánchez; Edward F Bell; Rosemary D Higgins Journal: Pediatr Res Date: 2013-09-04 Impact factor: 3.756
Authors: Dale L Phelps; Robert M Ward; Rick L Williams; Tracy L Nolen; Kristi L Watterberg; William Oh; Michael Goedecke; Richard A Ehrenkranz; Timothy Fennell; Brenda B Poindexter; C Michael Cotten; Mikko Hallman; Ivan D Frantz; Roger G Faix; Kristin M Zaterka-Baxter; Abhik Das; M Bethany Ball; Conra Backstrom Lacy; Michele C Walsh; Waldemar A Carlo; Pablo J Sánchez; Edward F Bell; Seetha Shankaran; David P Carlton; Patricia R Chess; Rosemary D Higgins Journal: Pediatr Res Date: 2016-04-13 Impact factor: 3.756
Authors: Anders K Nilsson; Abdellah Tebani; Daniel Malmodin; Anders Pedersen; Gunnel Hellgren; Chatarina Löfqvist; Ingrid Hansen-Pupp; Mathias Uhlén; Ann Hellström Journal: Front Neurosci Date: 2022-02-17 Impact factor: 4.677