| Literature DB >> 32931543 |
Lucas Schirmer1, Chloé Hoornaert2, Debbie Le Blon3, Dimitri Eigel1, Catia Neto4, Mark Gumbleton4, Petra B Welzel1, Anne E Rosser5, Carsten Werner6, Peter Ponsaerts3, Ben Newland7.
Abstract
Interleukin-13 (IL-13) drives cells of myeloid origin towards a more anti-inflammatory phenotype, but delivery to the brain remains problematic. Herein, we show that heparin-based cryogel microcarriers load high amounts of IL-13, releasing it slowly. Intra-striatal injection of loaded microcarriers caused local up-regulation of ARG1 in myeloid cells for pro-regenerative immunomodulation in the brain.Entities:
Mesh：
Substances：
Year: 2020 PMID： 32931543 DOI： 10.1039/d0bm01249a
Source DB: PubMed Journal: Biomater Sci ISSN： 2047-4830 Impact factor: 6.843