INTRODUCTION: The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic. Many studies have shown that several laboratory parameters are related to disease severity and mortality in SARS-CoV-2 cases. This meta-analysis aimed to determine the relationship of a prognostic factor, D-dimer, with disease severity, need for intensive care unit (ICU) care, and mortality in SARS-CoV-2 patients. METHODS: A systematic search for all observational studies and trials involving adult patients with SARS-CoV-2 that had any data related to D-dimer on admission was conducted using PubMed, Science Direct, Scopus, ProQuest, and MedRxiv databases. We performed random-effects inverse-variance weighting analysis using mean difference (MD) of D-dimer values for outcomes such as disease severity, mortality, and need for ICU care. RESULTS: A total of 29 studies (4,328 patients) were included in this meta-analysis, which revealed a higher mean of D-dimer levels on admission in severe patients than in nonsevere patients (MD = 0.95, [95% confidence interval (CI): 0.61-1.28], P < .05; I2 = 90%). The nonsurvivor group had a higher pooled MD of D-dimer values on admission (MD = 5.54 [95% CI: 3.40-7.67], P < .05; I2 = 90%). Patients who needed ICU admission had insignificantly higher D-dimer values than patients who did not need ICU admission (MD = 0.29, [95% CI: -0.05 to 0.63], P = .10; I2 = 71%). CONCLUSION: Elevated D-dimer levels on admission were associated with an increased risk of disease severity and mortality in patients with SARS-CoV-2 infection.
INTRODUCTION: The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic. Many studies have shown that several laboratory parameters are related to disease severity and mortality in SARS-CoV-2 cases. This meta-analysis aimed to determine the relationship of a prognostic factor, D-dimer, with disease severity, need for intensive care unit (ICU) care, and mortality in SARS-CoV-2patients. METHODS: A systematic search for all observational studies and trials involving adult patients with SARS-CoV-2 that had any data related to D-dimer on admission was conducted using PubMed, Science Direct, Scopus, ProQuest, and MedRxiv databases. We performed random-effects inverse-variance weighting analysis using mean difference (MD) of D-dimer values for outcomes such as disease severity, mortality, and need for ICU care. RESULTS: A total of 29 studies (4,328 patients) were included in this meta-analysis, which revealed a higher mean of D-dimer levels on admission in severe patients than in nonsevere patients (MD = 0.95, [95% confidence interval (CI): 0.61-1.28], P < .05; I2 = 90%). The nonsurvivor group had a higher pooled MD of D-dimer values on admission (MD = 5.54 [95% CI: 3.40-7.67], P < .05; I2 = 90%). Patients who needed ICU admission had insignificantly higher D-dimer values than patients who did not need ICU admission (MD = 0.29, [95% CI: -0.05 to 0.63], P = .10; I2 = 71%). CONCLUSION: Elevated D-dimer levels on admission were associated with an increased risk of disease severity and mortality in patients with SARS-CoV-2 infection.
Authors: Pedro Gutiérrez-Castrellón; Tania Gandara-Martí; Ana T Abreu Y Abreu; Cesar D Nieto-Rufino; Eduardo López-Orduña; Irma Jiménez-Escobar; Carlos Jiménez-Gutiérrez; Gabriel López-Velazquez; Jordi Espadaler-Mazo Journal: Gut Microbes Date: 2022 Jan-Dec
Authors: Luis García de Guadiana-Romualdo; Daniel Morell-García; Emmanuel J Favaloro; Juan A Vílchez; Josep M Bauça; María J Alcaide Martín; Irene Gutiérrez Garcia; Patricia de la Hera Cagigal; José Manuel Egea-Caparrós; Sonia Pérez Sanmartín; José I Gutiérrez Revilla; Eloísa Urrechaga; Jose M Álamo; Ana M Hernando Holgado; María-Carmen Lorenzo-Lozano; Magdalena Canalda Campás; María A Juncos Tobarra; Cristian Morales-Indiano; Isabel Vírseda Chamorro; Yolanda Pastor Murcia; Laura Sahuquillo Frías; Laura Altimira Queral; Elisa Nuez-Zaragoza; Juan Adell Ruiz de León; Alicia Ruiz Ripa; Paloma Salas Gómez-Pablos; Iria Cebreiros López; Amaia Fernández Uriarte; Alex Larruzea; María L López Yepes; Natalia Sancho-Rodríguez; María C Zamorano Andrés; José Pedregosa Díaz; Luis Sáenz; Clara Esparza Del Valle; María C Baamonde Calzada; Sara García Muñoz; Marina Vera; Esther Martín Torres; Silvia Sánchez Fdez-Pacheco; Luis Vicente Gutiérrez; Laura Jiménez Añón; Alfonso Pérez Martínez; Aurelio Pons Castillo; Ruth González Tamayo; Jorge Férriz Vivancos; Olaia Rodríguez-Fraga; Vicens Díaz-Brito; Vicente Aguadero; M G García Arévalo; María Arnaldos Carrillo; Mercedes González Morales; María Núñez Gárate; Cristina Ruiz Iruela; Patricia Esteban Torrella; Martí Vila Pérez; Cristina Acevedo Alcaraz; Alfonso L Blázquez-Manzanera; Amparo Galán Ortega Journal: J Thromb Thrombolysis Date: 2021-07-16 Impact factor: 2.300