Literature DB >> 3293088

Pharmacokinetic-pharmacodynamic modeling of CNS drug effects: an overview.

J Dingemanse1, M Danhof, D D Breimer.   

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Year:  1988        PMID: 3293088     DOI: 10.1016/0163-7258(88)90101-5

Source DB:  PubMed          Journal:  Pharmacol Ther        ISSN: 0163-7258            Impact factor:   12.310


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  27 in total

1.  Rate of change of blood concentrations is a major determinant of the pharmacodynamics of midazolam in rats.

Authors:  A Cleton; D Mazee; R A Voskuyl; M Danhof
Journal:  Br J Pharmacol       Date:  1999-05       Impact factor: 8.739

2.  A population pharmacokinetic-pharmacodynamic analysis of repeated measures time-to-event pharmacodynamic responses: the antiemetic effect of ondansetron.

Authors:  E H Cox; C Veyrat-Follet; S L Beal; E Fuseau; S Kenkare; L B Sheiner
Journal:  J Pharmacokinet Biopharm       Date:  1999-12

3.  Pharmacokinetic-pharmacodynamic modelling of the EEG effects of midazolam in individual rats: influence of rate and route of administration.

Authors:  J W Mandema; E Tukker; M Danhof
Journal:  Br J Pharmacol       Date:  1991-03       Impact factor: 8.739

Review 4.  Electroencephalogram effect measures and relationships between pharmacokinetics and pharmacodynamics of centrally acting drugs.

Authors:  J W Mandema; M Danhof
Journal:  Clin Pharmacokinet       Date:  1992-09       Impact factor: 6.447

5.  Pharmacokinetic-pharmacodynamic modeling of the central nervous system effects of heptabarbital using aperiodic EEG analysis.

Authors:  J W Mandema; M Danhof
Journal:  J Pharmacokinet Biopharm       Date:  1990-10

Review 6.  The use of kinetic-dynamic interactions in the evaluation of drugs.

Authors:  D B Campbell
Journal:  Psychopharmacology (Berl)       Date:  1990       Impact factor: 4.530

7.  Relationship between receptor occupancy at 37 degrees C and the anticonvulsant effect of flunitrazepam in rats.

Authors:  M Hollander-Jansen; J Dingemanse; M W Langemeijer; M Danhof
Journal:  Pharm Res       Date:  1989-07       Impact factor: 4.200

8.  Benzodiazepine pharmacodynamics: utility of eye movement measures.

Authors:  P P Roy-Byrne; D S Cowley; A Radant; D Hommer; D J Greenblatt
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

9.  Deoxyribose analogues of N6-cyclopentyladenosine (CPA): partial agonists at the adenosine A1 receptor in vivo.

Authors:  R A Mathôt; E M Van der Wenden; W Soudijn; A P IJzerman; M Danhof
Journal:  Br J Pharmacol       Date:  1995-10       Impact factor: 8.739

10.  Differences in intrinsic efficacy of benzodiazepines are reflected in their concentration-EEG effect relationship.

Authors:  J W Mandema; M T Kuck; M Danhof
Journal:  Br J Pharmacol       Date:  1992-01       Impact factor: 8.739

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