| Literature DB >> 32930635 |
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Abstract
Entities:
Year: 2020 PMID: 32930635 PMCID: PMC7491407 DOI: 10.1164/rccm.v202erratum4
Source DB: PubMed Journal: Am J Respir Crit Care Med ISSN: 1073-449X Impact factor: 21.405
RR of IGRA Conversion at 14 Weeks, by M. tuberculosis Genotype and by BCG Vaccination Stratified by M. tuberculosis Genotype
| IGRA Negative
( | IGRA Positive
( | RR | 95% CI | ARR | 95% CI | |||
|---|---|---|---|---|---|---|---|---|
| RR of IGRA conversion in
contacts by index case | ||||||||
| Other genotype | 206 | 69 | 1.00 | Ref. | 1.00 | Ref. | ||
| Beijing genotype | 69 | 39 | 1.44 | 0.98–2.10 | 0.06 | 1.39 | 1.00–1.93 | 0.048 |
| RR of IGRA conversion by
contact BCG vaccination status and index case | ||||||||
| Other genotype | ||||||||
| BCG: No | 22 | 21 | 1.00 | Ref. | 1.00 | Ref. | ||
| BCG: Yes | 184 | 48 | 0.42 | 0.28–0.63 | <0.001 | 0.40 | 0.27–0.61 | <0.001 |
| Beijing genotype | ||||||||
| BCG: No | 13 | 7 | 1.00 | Ref. | 1.00 | Ref. | ||
| BCG: Yes | 56 | 32 | 1.04 | 0.54–2.01 | 0.9 | 1.02 | 0.56–1.85 | 0.9 |
Definition of abbreviations: ARR = adjusted relative risk; BCG = bacillus Calmette-Guérin; CI = confidence interval; IGRA = IFN-γ release assay; M. tuberculosis = Mycobacterium tuberculosis; Ref. = reference; RR = relative risk.
Estimates obtained by multiple regression, adjusted for index case age, sex, smear grade, contact age, sex, hours spent with index case, smoking, BCG vaccination, and body mass index. Index case cough duration, cavities, extent of X-ray disease, drug resistance, and multidrug resistance were not retained in the model, nor was contact diabetes status.
Estimates obtained by multiple regression, adjusted for index case age, sex, smear grade, contact age, sex, hours spent with index case, smoking, body mass index, and an interaction term for BCG and strain genotype. Index case cough duration, cavities, extent of X-ray disease, drug resistance, and multidrug resistance were not retained in the model, nor was contact diabetes status.